{"id":"https://openalex.org/W3098256898","doi":"https://doi.org/10.1145/3388440.3414919","title":"Novel Generated Peptides for COVID-19 Targets","display_name":"Novel Generated Peptides for COVID-19 Targets","publication_year":2020,"publication_date":"2020-09-21","ids":{"openalex":"https://openalex.org/W3098256898","doi":"https://doi.org/10.1145/3388440.3414919","mag":"3098256898"},"language":"en","primary_location":{"id":"doi:10.1145/3388440.3414919","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3388440.3414919","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 11th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036129205","display_name":"Allison M. Rossetto","orcid":null},"institutions":[{"id":"https://openalex.org/I133738476","display_name":"University of Massachusetts Lowell","ror":"https://ror.org/03hamhx47","country_code":"US","type":"education","lineage":["https://openalex.org/I133738476"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allison Rossetto","raw_affiliation_strings":["University of Massachusetts Lowell, Lowell, Massachusetts"],"affiliations":[{"raw_affiliation_string":"University of Massachusetts Lowell, Lowell, Massachusetts","institution_ids":["https://openalex.org/I133738476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101854442","display_name":"Wenjin Zhou","orcid":"https://orcid.org/0009-0009-8416-1621"},"institutions":[{"id":"https://openalex.org/I133738476","display_name":"University of Massachusetts Lowell","ror":"https://ror.org/03hamhx47","country_code":"US","type":"education","lineage":["https://openalex.org/I133738476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjin Zhou","raw_affiliation_strings":["University of Massachusetts Lowell, Lowell, Massachusetts"],"affiliations":[{"raw_affiliation_string":"University of Massachusetts Lowell, Lowell, Massachusetts","institution_ids":["https://openalex.org/I133738476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036129205"],"corresponding_institution_ids":["https://openalex.org/I133738476"],"apc_list":null,"apc_paid":null,"fwci":0.1407,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54234141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9783999919891357,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyproteins","display_name":"Polyproteins","score":0.9597311019897461},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.7308914661407471},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.6616447567939758},{"id":"https://openalex.org/keywords/protease","display_name":"Protease","score":0.5728644132614136},{"id":"https://openalex.org/keywords/coronavirus","display_name":"Coronavirus","score":0.5653941035270691},{"id":"https://openalex.org/keywords/2019-20-coronavirus-outbreak","display_name":"2019-20 coronavirus outbreak","score":0.5645207762718201},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5221962332725525},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.4581323266029358},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme-2","display_name":"Angiotensin-converting enzyme 2","score":0.4531850516796112},{"id":"https://openalex.org/keywords/pandemic","display_name":"Pandemic","score":0.4400229752063751},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.398328959941864},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.34545236825942993},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2727513313293457},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.2098747193813324},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1419447362422943},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11456155776977539}],"concepts":[{"id":"https://openalex.org/C2910895815","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Polyproteins","level":4,"score":0.9597311019897461},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.7308914661407471},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.6616447567939758},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.5728644132614136},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.5653941035270691},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.5645207762718201},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5221962332725525},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4581323266029358},{"id":"https://openalex.org/C2775946041","wikidata":"https://www.wikidata.org/wiki/Q14875321","display_name":"Angiotensin-converting enzyme 2","level":5,"score":0.4531850516796112},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.4400229752063751},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.398328959941864},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34545236825942993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2727513313293457},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2098747193813324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1419447362422943},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11456155776977539},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3388440.3414919","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3388440.3414919","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 11th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2010082441","https://openalex.org/W2135634425","https://openalex.org/W2973082767","https://openalex.org/W3022192503"],"related_works":["https://openalex.org/W2015779011","https://openalex.org/W4385324756","https://openalex.org/W3171689025","https://openalex.org/W3122361513","https://openalex.org/W1982047676","https://openalex.org/W3081366043","https://openalex.org/W1527409215","https://openalex.org/W4205889518","https://openalex.org/W2172500117","https://openalex.org/W3015753260"],"abstract_inverted_index":{"With":[0],"the":[1,4,98,104,127,137],"world":[2],"in":[3,70,126],"midst":[5],"of":[6,87,136],"a":[7],"global":[8],"pandemic,":[9],"it":[10],"is":[11,36,110],"important":[12,69,95],"to":[13,16,40,51,79,83,112,133],"be":[14,41],"able":[15,111],"quickly":[17],"generate":[18,80],"new":[19,81],"drug-like":[20],"compounds":[21],"for":[22],"drug":[23],"research":[24],"purposes.":[25],"While":[26],"some":[27],"successful":[28],"work":[29,39],"has":[30],"been":[31],"done":[32],"[3,":[33],"6]":[34],"there":[35],"still":[37],"much":[38],"done,":[42],"especially":[43],"as":[44],"viruses":[45],"like":[46],"Coronavirus":[47],"are":[48,56,91],"notoriously":[49],"hard":[50],"treat.":[52],"Since":[53],"peptide":[54],"drugs":[55,66],"generally":[57],"better":[58],"at":[59],"blocking":[60],"protein-protein":[61],"interactions":[62],"than":[63],"small":[64],"molecule":[65],"[5],":[67],"something":[68],"anti-viral":[71],"work,":[72],"we":[73,90],"will":[74],"use":[75],"our":[76],"GANDALF":[77],"methodology":[78],"peptides":[82],"interact":[84],"with":[85,93],"targets":[86],"interest.":[88],"Here":[89],"working":[92],"two":[94],"COVID-19":[96],"targets:":[97],"SARS-CoV-2":[99],"main":[100],"protease":[101],"(M[Pro])":[102],"and":[103,122],"andangiotensin-converting":[105],"enzyme":[106],"2":[107],"(ACE2).":[108],"Covid-19":[109],"enter":[113],"human":[114],"cells":[115],"via":[116],"interaction":[117],"between":[118],"its":[119],"spike":[120],"protein":[121],"ACE2":[123],"and,":[124],"once":[125],"cell,":[128],"MPro":[129],"breaks":[130],"down":[131],"polyproteins":[132],"create":[134],"more":[135],"virus":[138],"[1].":[139]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
