{"id":"https://openalex.org/W2749539265","doi":"https://doi.org/10.1145/3107411.3108229","title":"Microbiome Dynamics as Predictors of Lung Transplant Rejection","display_name":"Microbiome Dynamics as Predictors of Lung Transplant Rejection","publication_year":2017,"publication_date":"2017-08-20","ids":{"openalex":"https://openalex.org/W2749539265","doi":"https://doi.org/10.1145/3107411.3108229","mag":"2749539265"},"language":"en","primary_location":{"id":"doi:10.1145/3107411.3108229","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3107411.3108229","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology,and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086750542","display_name":"Ahmed A. Metwally","orcid":"https://orcid.org/0000-0002-0155-7412"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ahmed Metwally","raw_affiliation_strings":["University of Illinois at Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024187027","display_name":"Christian Ascoli","orcid":"https://orcid.org/0000-0002-7424-2710"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Ascoli","raw_affiliation_strings":["University of Illinois at Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048379692","display_name":"Kalista Andropolis","orcid":null},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalista Andropolis","raw_affiliation_strings":["University of Illinois at Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101800224","display_name":"Ravi Ranjan","orcid":"https://orcid.org/0000-0002-8768-549X"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Ranjan","raw_affiliation_strings":["University of Illinois at Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025440962","display_name":"Yang Dai","orcid":"https://orcid.org/0000-0002-7638-849X"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Dai","raw_affiliation_strings":["University of Illinois at Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110354642","display_name":"Thomas Ferkol","orcid":null},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Ferkol","raw_affiliation_strings":["Washington University School of Medicine, St. Louis , MO, USA"],"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis , MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088506690","display_name":"Patricia W. Finn","orcid":"https://orcid.org/0000-0001-6936-103X"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Finn","raw_affiliation_strings":["University of Illinois at Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043635194","display_name":"David L. Perkins","orcid":"https://orcid.org/0000-0002-0164-6036"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Perkins","raw_affiliation_strings":["University of Illinois at Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5086750542"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17439206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"619","last_page":"619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.958299994468689,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9259999990463257,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bronchiolitis-obliterans","display_name":"Bronchiolitis obliterans","score":0.8218133449554443},{"id":"https://openalex.org/keywords/lung-transplantation","display_name":"Lung transplantation","score":0.7717583179473877},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5669649243354797},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"Bronchoalveolar lavage","score":0.5514732599258423},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.5264801979064941},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5179026126861572},{"id":"https://openalex.org/keywords/microbiome","display_name":"Microbiome","score":0.5074836611747742},{"id":"https://openalex.org/keywords/pneumonia","display_name":"Pneumonia","score":0.5038709044456482},{"id":"https://openalex.org/keywords/transplantation","display_name":"Transplantation","score":0.49344077706336975},{"id":"https://openalex.org/keywords/tropheryma-whipplei","display_name":"Tropheryma whipplei","score":0.48558372259140015},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.36666592955589294},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3555399775505066},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.319968044757843},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.18617740273475647},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.15396860241889954}],"concepts":[{"id":"https://openalex.org/C2776739411","wikidata":"https://www.wikidata.org/wiki/Q614750","display_name":"Bronchiolitis obliterans","level":4,"score":0.8218133449554443},{"id":"https://openalex.org/C2781448352","wikidata":"https://www.wikidata.org/wiki/Q1637912","display_name":"Lung transplantation","level":3,"score":0.7717583179473877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5669649243354797},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.5514732599258423},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5264801979064941},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5179026126861572},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5074836611747742},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.5038709044456482},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.49344077706336975},{"id":"https://openalex.org/C2780647328","wikidata":"https://www.wikidata.org/wiki/Q2703876","display_name":"Tropheryma whipplei","level":4,"score":0.48558372259140015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36666592955589294},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3555399775505066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.319968044757843},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.18617740273475647},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.15396860241889954},{"id":"https://openalex.org/C2777440137","wikidata":"https://www.wikidata.org/wiki/Q653078","display_name":"Whipple's disease","level":3,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3107411.3108229","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3107411.3108229","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology,and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4399999976158142,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2036915786","https://openalex.org/W2042577913","https://openalex.org/W1997430425","https://openalex.org/W1989080740","https://openalex.org/W2028865642","https://openalex.org/W162331040","https://openalex.org/W2118384216","https://openalex.org/W2059654686","https://openalex.org/W2774903098","https://openalex.org/W1987284966"],"abstract_inverted_index":{"Lung":[0],"transplantation":[1],"offers":[2],"the":[3,24,54,65,68,71,77,145,150,170,189,198,212,216,228,251,259,266,285],"only":[4,33],"treatment":[5],"for":[6,29,40,125],"multiple":[7,111],"chronic":[8,49],"diseases.":[9],"Transplantation":[10],"is":[11,32,45,63,85,133,207,270],"dependent":[12],"upon":[13],"successful":[14],"resistance":[15],"to":[16,48,89,148,242,250,272],"organ":[17],"rejection.":[18],"For":[19],"children,":[20],"a":[21,166,193],"vulnerable":[22],"population,":[23],"five":[25],"and":[26,35,79,93,179,222,256,261,287],"ten-year":[27],"survival":[28,43,96],"lung":[30,50,98,107,171,217],"transplants":[31],"52%":[34],"29%,":[36],"respectively.":[37],"The":[38,128,140,173],"reason":[39],"this":[41,162],"low":[42],"rate":[44],"primary":[46],"due":[47],"graft":[51,82],"rejection":[52,83],"in":[53,67,86,97,169,227],"form":[55],"of":[56,70,81,161,205,281],"Bronchiolitis":[57],"Obliterans":[58],"Syndrome":[59],"(BOS).":[60],"Our":[61],"hypothesis":[62],"that":[64,158,238],"changes":[66],"composition":[69],"pulmonary":[72],"microbiome":[73,168],"are":[74,224],"associated":[75,208],"with":[76,209],"development":[78],"progression":[80],"which":[84],"turn":[87],"related":[88],"detrimental":[90],"cardiopulmonary":[91],"outcomes":[92],"poor":[94],"overall":[95],"transplant":[99,108],"recipients.":[100],"Samples":[101],"were":[102,118],"obtained":[103],"from":[104,131],"6":[105],"pediatric":[106],"patients":[109],"over":[110],"time":[112,123,201,263,277,282,292],"points.":[113,293],"Bronchoalveolar":[114],"lavage":[115],"(BAL)":[116],"samples":[117],"collected":[119],"at":[120,275],"approximately":[121],"7":[122],"points":[124,264,283],"each":[126],"subject.":[127],"DNA":[129],"isolated":[130],"BAL":[132],"sequenced":[134],"on":[135,197],"an":[136,235],"Illumina":[137],"MiSeq":[138],"machine.":[139],"longitudinal":[141,291],"taxonomic":[142,200],"profiles":[143],"demonstrate":[144],"phylum":[146,163],"Proteobacteria":[147],"be":[149,240],"most":[151],"abundant":[152,226],"across":[153],"all":[154],"samples.":[155],"This":[156],"suggests":[157],"certain":[159],"members":[160],"may":[164],"indicate":[165],"core":[167],"graft.":[172],"association":[174],"between":[175,290],"Pseudomonas":[176],"aeruginosa":[177],"overgrowth":[178],"clinically":[180],"suspected":[181],"infection":[182,210],"requiring":[183],"antibiotic":[184],"therapy":[185],"was":[186],"evaluated":[187],"throughout":[188],"study":[190],"period":[191],"employing":[192],"Smoothing":[194],"Splines":[195],"ANOVA":[196],"microbial":[199],"series'":[202],"profile.":[203],"Overgrowth":[204],"Cellulomonas":[206],"during":[211],"early":[213],"days":[214],"after":[215],"transplantation.":[218],"Conversely,":[219],"Bradyrhizobium,":[220],"Acetobacter,":[221],"Coriobacterium":[223],"more":[225],"non-infected":[229],"subjects.":[230],"We":[231],"also":[232],"propose":[233],"MetaLonDA,":[234],"R":[236],"package":[237],"can":[239],"used":[241],"accurately":[243,257],"detect":[244,258],"metagenomic":[245],"features":[246],"(species,":[247],"genes)":[248],"relating":[249],"phenotype":[252],"or":[253],"disease":[254],"status,":[255],"starting":[260],"ending":[262],"when":[265],"differences":[267],"arise.":[268],"It":[269],"able":[271],"handle":[273],"sampling":[274],"different":[276],"points,":[278],"unequal":[279],"number":[280],"among":[284],"subjects,":[286],"long":[288],"gap":[289]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}