{"id":"https://openalex.org/W7171564470","doi":"https://doi.org/10.1145/3807503.3819798","title":"Estimating Continuous Chemotherapy Effect Trajectories in Head and Neck Squamous Cell Carcinoma","display_name":"Estimating Continuous Chemotherapy Effect Trajectories in Head and Neck Squamous Cell Carcinoma","publication_year":2026,"publication_date":"2026-06-30","ids":{"openalex":"https://openalex.org/W7171564470","doi":"https://doi.org/10.1145/3807503.3819798"},"language":null,"primary_location":{"id":"doi:10.1145/3807503.3819798","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3807503.3819798","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 17th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1145/3807503.3819798","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119722783","display_name":"Everest Yang","orcid":"https://orcid.org/0000-0001-6066-8254"},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Everest Yang","raw_affiliation_strings":["Brown University, Providence, RI, USA"],"raw_orcid":"https://orcid.org/0009-0006-5626-6774","affiliations":[{"raw_affiliation_string":"Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143765922","display_name":"Ria Vasishtha","orcid":"https://orcid.org/0009-0008-1541-7198"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ria Vasishtha","raw_affiliation_strings":["Columbia University, New York, NY, USA"],"raw_orcid":"https://orcid.org/0009-0008-1541-7198","affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010067099","display_name":"Andrew Hope","orcid":"https://orcid.org/0000-0001-6793-2863"},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew Hope","raw_affiliation_strings":["Princess Margaret Cancer Centre, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0001-6793-2863","affiliations":[{"raw_affiliation_string":"Princess Margaret Cancer Centre, Toronto, ON, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083156203","display_name":"Lisa A. Kachnic","orcid":"https://orcid.org/0000-0001-8239-9147"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa A. Kachnic","raw_affiliation_strings":["Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-8239-9147","affiliations":[{"raw_affiliation_string":"Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100746980","display_name":"Eric Wang","orcid":"https://orcid.org/0000-0002-5963-1670"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Wang","raw_affiliation_strings":["Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-5963-1670","affiliations":[{"raw_affiliation_string":"Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044358814","display_name":"Igor Shuryak","orcid":"https://orcid.org/0000-0001-9314-5708"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor Shuryak","raw_affiliation_strings":["Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-9314-5708","affiliations":[{"raw_affiliation_string":"Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":null,"topics":[],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck","display_name":"Head and neck","score":0.616100013256073},{"id":"https://openalex.org/keywords/basal-cell","display_name":"Basal cell","score":0.4675999879837036},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"Head and neck squamous-cell carcinoma","score":0.4318000078201294},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.4244999885559082},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.3675000071525574},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"Head and neck cancer","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8367000222206116},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.616100013256073},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4878999888896942},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4690000116825104},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.4675999879837036},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4334999918937683},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.4318000078201294},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4244999885559082},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3675000071525574},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.34700000286102295},{"id":"https://openalex.org/C2994460389","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Epidermoid carcinoma","level":3,"score":0.34439998865127563},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3125},{"id":"https://openalex.org/C2780312720","wikidata":"https://www.wikidata.org/wiki/Q5689100","display_name":"Head (geology)","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2757999897003174},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.2590000033378601},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25529998540878296}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3807503.3819798","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3807503.3819798","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 17th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1145/3807503.3819798","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3807503.3819798","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 17th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1988306828","https://openalex.org/W2024027732","https://openalex.org/W2087789972","https://openalex.org/W2118772763","https://openalex.org/W2155655193","https://openalex.org/W2208550830","https://openalex.org/W2624816748","https://openalex.org/W2759286633","https://openalex.org/W2789400833","https://openalex.org/W2903560851","https://openalex.org/W2905889700","https://openalex.org/W2913777136","https://openalex.org/W2962727190","https://openalex.org/W2989150632","https://openalex.org/W3037834198","https://openalex.org/W3083155866","https://openalex.org/W3107533236","https://openalex.org/W3137086806","https://openalex.org/W4291278868","https://openalex.org/W4312582671","https://openalex.org/W4322397527","https://openalex.org/W4327685932","https://openalex.org/W4380989287","https://openalex.org/W4391577308","https://openalex.org/W4392539472","https://openalex.org/W4399141494","https://openalex.org/W4399390361","https://openalex.org/W4400061223","https://openalex.org/W4401032284","https://openalex.org/W4401603869","https://openalex.org/W4402581869","https://openalex.org/W4403910747","https://openalex.org/W6902966892"],"related_works":[],"abstract_inverted_index":{"Causal":[0,51],"machine":[1],"learning":[2],"(CML)":[3],"provides":[4],"a":[5,82,109],"framework":[6,59,169],"for":[7,25,53,162],"estimating":[8],"treatment":[9,62,147,164],"effects":[10,36,63,148],"in":[11],"complex":[12],"data,":[13,29],"making":[14],"it":[15],"preferable":[16],"to":[17,45,60,97,105,124,132,175],"traditional":[18],"correlation-based":[19],"methods.":[20],"However,":[21],"existing":[22],"causal":[23,31],"methods":[24],"censored":[26],"medical":[27,183],"survival":[28,32],"including":[30],"forests":[33],"(CSFs),":[34],"estimate":[35,98],"at":[37,137],"fixed":[38],"time":[39,136],"points,":[40],"which":[41],"limits":[42],"their":[43],"ability":[44],"capture":[46],"temporal":[47],"dynamics.":[48],"We":[49,102],"introduce":[50],"Analysis":[52],"Survival":[54],"Trajectories":[55],"(CAST),":[56],"an":[57],"effective":[58],"model":[61,125],"as":[64],"continuous":[65,99],"functions":[66],"of":[67,84,93,113,129,173,178],"time.":[68],"It":[69],"does":[70],"so":[71],"by":[72],"smoothing":[73],"discrete-time":[74],"estimates":[75],"from":[76],"CSFs":[77],"following":[78],"treatment.":[79],"By":[80],"leveraging":[81],"combination":[83],"parametric":[85],"and":[86,118,141,151,161,180],"non-parametric":[87],"methods,":[88],"CAST":[89,104,144],"overcomes":[90],"the":[91,106,127,139,154,171],"limitations":[92],"discrete":[94],"time-point":[95],"analysis":[96],"effect":[100,128],"trajectories.":[101],"apply":[103],"RADCURE":[107],"dataset,":[108],"clinically":[110],"relevant":[111],"cohort":[112],"2,651":[114],"patients":[115],"with":[116],"head":[117],"neck":[119],"squamous":[120],"cell":[121],"carcinoma":[122],"(HNSCC),":[123],"how":[126,146],"adding":[130],"chemotherapy":[131],"radiotherapy":[133],"changes":[134],"over":[135],"both":[138],"population":[140],"individual":[142],"levels.":[143],"reveals":[145],"increase,":[149],"peak":[150],"decline":[152],"during":[153],"follow-up":[155],"period,":[156],"helping":[157],"clinicians":[158],"determine":[159],"when":[160],"whom":[163],"benefits":[165],"are":[166],"maximized.":[167],"This":[168],"advances":[170],"application":[172],"CML":[174],"personalized":[176],"care":[177],"HNSCC":[179],"other":[181],"life-threatening":[182],"conditions.":[184]},"counts_by_year":[],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2026-07-29T00:00:00"}