{"id":"https://openalex.org/W7124177267","doi":"https://doi.org/10.1145/3777577.3777714","title":"Utilizing Network Pharmacology and Molecular Docking to Analyze the Mechanism of Huanglian-Zhimu-Chishao in Treating Type 2 Diabetes Mellitus","display_name":"Utilizing Network Pharmacology and Molecular Docking to Analyze the Mechanism of Huanglian-Zhimu-Chishao in Treating Type 2 Diabetes Mellitus","publication_year":2025,"publication_date":"2025-10-24","ids":{"openalex":"https://openalex.org/W7124177267","doi":"https://doi.org/10.1145/3777577.3777714"},"language":null,"primary_location":{"id":"doi:10.1145/3777577.3777714","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3777577.3777714","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2025 6th International Symposium on Artificial Intelligence for Medical Sciences","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1145/3777577.3777714","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123026285","display_name":"Chenfei Lv","orcid":null},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chenfei Lv","raw_affiliation_strings":["College of Basic Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0009-0001-7711-0879","affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082568576","display_name":"Yunmiao Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunmiao Wu","raw_affiliation_strings":["College of Basic Medical Sciences, Changchun University of Chinese Medicine, Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0009-0006-0767-1298","affiliations":[{"raw_affiliation_string":"College of Basic Medical Sciences, Changchun University of Chinese Medicine, Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039922737","display_name":"Q. Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Wang","raw_affiliation_strings":["College of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine, Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0009-0009-8132-1386","affiliations":[{"raw_affiliation_string":"College of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine, Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"last","author":{"id":null,"display_name":"Rui Chen","orcid":"https://orcid.org/0000-0003-4236-9976"},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Chen","raw_affiliation_strings":["College of Fundamental Medicine, Changchun University of Traditional Chinese Medicine, Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0000-0003-4236-9976","affiliations":[{"raw_affiliation_string":"College of Fundamental Medicine, Changchun University of Traditional Chinese Medicine, Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5123026285"],"corresponding_institution_ids":["https://openalex.org/I4210128075"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73249203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"849","last_page":"856"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.11869999766349792,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.11869999766349792,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.08630000054836273,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.07400000095367432,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pubchem","display_name":"PubChem","score":0.8715999722480774},{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.7383000254631042},{"id":"https://openalex.org/keywords/drugbank","display_name":"DrugBank","score":0.6635000109672546},{"id":"https://openalex.org/keywords/autodock","display_name":"AutoDock","score":0.5965999960899353},{"id":"https://openalex.org/keywords/druggability","display_name":"Druggability","score":0.5052000284194946},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5047000050544739},{"id":"https://openalex.org/keywords/systems-pharmacology","display_name":"Systems pharmacology","score":0.4862000048160553},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.48159998655319214},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.43220001459121704}],"concepts":[{"id":"https://openalex.org/C158180186","wikidata":"https://www.wikidata.org/wiki/Q278487","display_name":"PubChem","level":2,"score":0.8715999722480774},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.7383000254631042},{"id":"https://openalex.org/C155261790","wikidata":"https://www.wikidata.org/wiki/Q1122544","display_name":"DrugBank","level":3,"score":0.6635000109672546},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6384999752044678},{"id":"https://openalex.org/C2780152424","wikidata":"https://www.wikidata.org/wiki/Q4826062","display_name":"AutoDock","level":4,"score":0.5965999960899353},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.5052000284194946},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5047000050544739},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.4862000048160553},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.48159998655319214},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.43220001459121704},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.4124999940395355},{"id":"https://openalex.org/C3018795828","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Binding affinities","level":3,"score":0.38690000772476196},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.3603000044822693},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3540000021457672},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34769999980926514},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3176000118255615},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.3125999867916107},{"id":"https://openalex.org/C65556437","wikidata":"https://www.wikidata.org/wiki/Q766195","display_name":"Protein Data Bank (RCSB PDB)","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C68762167","wikidata":"https://www.wikidata.org/wiki/Q910164","display_name":"Cheminformatics","level":2,"score":0.28870001435279846},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.27950000762939453},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.27649998664855957},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26980000734329224},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.2678000032901764},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26499998569488525},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.2590999901294708},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2590000033378601}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3777577.3777714","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3777577.3777714","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2025 6th International Symposium on Artificial Intelligence for Medical Sciences","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1145/3777577.3777714","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3777577.3777714","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2025 6th International Symposium on Artificial Intelligence for Medical Sciences","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.7751514315605164,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W2970534831","https://openalex.org/W3107527779","https://openalex.org/W4300773217","https://openalex.org/W4307468223","https://openalex.org/W4396793229","https://openalex.org/W4404718856","https://openalex.org/W4410016373"],"related_works":[],"abstract_inverted_index":{"This":[0],"study":[1],"probed":[2],"into":[3],"the":[4,42,46,57,118,122,156,185,188,201,212,246],"therapeutic":[5,247],"mechanism":[6],"of":[7,23,59,121,131,187],"Huanglian-Zhimu-Chishao":[8,24,135,224],"compound":[9],"on":[10],"T2DM":[11,232],"via":[12],"network":[13,69,84],"pharmacology":[14],"and":[15,21,31,35,61,64,103,112,125,136,153,155,164,176,209,211,222],"molecular":[16,108,189],"docking.":[17],"The":[18,144,234],"major":[19,123],"constituents":[20],"targets":[22,94,133,138,142,158,203,240],"were":[25,38,49,114,171],"identified":[26],"by":[27],"using":[28,70],"TCMSP,":[29],"PubChem":[30],"SwissTargetPrediction":[32],"database.":[33],"GeneCards":[34],"OMIM":[36],"databases":[37],"used":[39,81,99,115],"to":[40,55,73,100,116],"obtain":[41],"T2DM-related":[43],"target":[44],"genes,":[45],"duplicate":[47],"ones":[48],"deleted.":[50],"We":[51],"use":[52],"Venny":[53],"2.1.0":[54],"determine":[56],"overlap":[58],"component":[60],"disease":[62],"target,":[63],"then":[65],"establish":[66],"a":[67,227],"\u201cdrug-component-target\u201d":[68],"Cytoscape":[71,89],"3.7.1":[72],"find":[74,193],"key":[75],"active":[76,146,214,235],"components.":[77],"String":[78],"database":[79,97],"is":[80,90],"for":[82,92,134,139,249],"PPI":[83],"analysis,":[85,181,191],"topological":[86],"screening":[87],"in":[88,231],"applied":[91],"drug-disease":[93],"identification.":[95],"DAVID":[96],"was":[98],"conduct":[101],"GO":[102,166],"KEGG":[104,179],"pathway":[105,180],"analysis.":[106],"Lastly,":[107],"docking":[109,190],"through":[110,241],"Autodock":[111],"PyMOL":[113],"examine":[117],"binding":[119,198],"affinities":[120,199],"components":[124,147,236],"their":[126],"respective":[127],"target.":[128],"A":[129],"total":[130],"458":[132],"2,393":[137],"T2DM,":[140],"239":[141],"overlapped.":[143],"main":[145,157,202,213],"included":[148,159],"quercetin,":[149,218],"kaempferol,":[150],"albiflorin,":[151],"stigmasterol,":[152],"obacunone,":[154],"AKT1,":[160,205],"TNF,":[161,206],"IL6,":[162,207],"TP53,":[163,208],"EGFR.":[165],"analysis":[167],"showed":[168],"that":[169,194],"there":[170,195],"991":[172],"BP,":[173],"116":[174],"CC,":[175],"204":[177],"MF.":[178],"188":[182],"pathways.":[183],"From":[184],"results":[186],"we":[192],"are":[196],"strong":[197],"between":[200],"like":[204],"EGFR,":[210],"ingredients":[215],"such":[216],"as":[217],"Kaempferol,":[219],"Albiflorin,":[220],"Stigmasterol,":[221],"Obacunone.":[223],"combination":[225],"has":[226],"multi-target":[228],"comprehensive":[229],"effect":[230],"treatment.":[233],"regulate":[237],"various":[238],"disease-related":[239],"multiple":[242],"pathways,":[243],"thereby":[244],"improving":[245],"outcome":[248],"T2DM.":[250]},"counts_by_year":[],"updated_date":"2026-01-15T23:21:31.212559","created_date":"2026-01-15T00:00:00"}
