{"id":"https://openalex.org/W4417062422","doi":"https://doi.org/10.1145/3768322.3769017","title":"Promises and Pitfalls of Large Language Models use to interpret Healthcare Guidelines","display_name":"Promises and Pitfalls of Large Language Models use to interpret Healthcare Guidelines","publication_year":2025,"publication_date":"2025-10-11","ids":{"openalex":"https://openalex.org/W4417062422","doi":"https://doi.org/10.1145/3768322.3769017"},"language":null,"primary_location":{"id":"doi:10.1145/3768322.3769017","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3768322.3769017","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Companion Proceedings of the 16th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045360539","display_name":"Raghav Awasthi","orcid":"https://orcid.org/0000-0002-6643-4333"},"institutions":[{"id":"https://openalex.org/I4210147129","display_name":"BrainAid (United States)","ror":"https://ror.org/04k00np26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raghav Awasthi","raw_affiliation_strings":["BrainXAI Research, BrainX,LLC., Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0002-6643-4333","affiliations":[{"raw_affiliation_string":"BrainXAI Research, BrainX,LLC., Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210147129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075582759","display_name":"SP Mishra","orcid":"https://orcid.org/0009-0000-1052-5546"},"institutions":[{"id":"https://openalex.org/I4210147129","display_name":"BrainAid (United States)","ror":"https://ror.org/04k00np26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shreya Mishra","raw_affiliation_strings":["BrainXAI Research, BrainX,LLC., Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0009-0000-1052-5546","affiliations":[{"raw_affiliation_string":"BrainXAI Research, BrainX,LLC., Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210147129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118646368","display_name":"Ashish Atreja","orcid":"https://orcid.org/0009-0000-8170-2861"},"institutions":[{"id":"https://openalex.org/I4210147129","display_name":"BrainAid (United States)","ror":"https://ror.org/04k00np26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashish Atreja","raw_affiliation_strings":["BrainXAI Research, BrainX,LLC., Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0009-0000-8170-2861","affiliations":[{"raw_affiliation_string":"BrainXAI Research, BrainX,LLC., Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210147129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108155185","display_name":"Charumathi Raghu Subramanian","orcid":"https://orcid.org/0000-0003-1283-0514"},"institutions":[{"id":"https://openalex.org/I4210147129","display_name":"BrainAid (United States)","ror":"https://ror.org/04k00np26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charumathi Raghu Subramanian","raw_affiliation_strings":["BrainXAI Research, BrainX,LLC., Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-1283-0514","affiliations":[{"raw_affiliation_string":"BrainXAI Research, BrainX,LLC., Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210147129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032041757","display_name":"Mois\u00e9s Aur\u00f3n","orcid":"https://orcid.org/0000-0001-6398-6047"},"institutions":[{"id":"https://openalex.org/I4210147129","display_name":"BrainAid (United States)","ror":"https://ror.org/04k00np26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moises Auron","raw_affiliation_strings":["BrainXAI Research, BrainX,LLC., Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0001-6398-6047","affiliations":[{"raw_affiliation_string":"BrainXAI Research, BrainX,LLC., Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210147129"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nishant Singh","orcid":"https://orcid.org/0009-0003-3692-7254"},"institutions":[{"id":"https://openalex.org/I4210147129","display_name":"BrainAid (United States)","ror":"https://ror.org/04k00np26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nishant Singh","raw_affiliation_strings":["BrainXAI Research, BrainX,LLC., Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0009-0003-3692-7254","affiliations":[{"raw_affiliation_string":"BrainXAI Research, BrainX,LLC., Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210147129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010019712","display_name":"Jacek B. Cywi\u0144ski","orcid":"https://orcid.org/0000-0001-6283-3049"},"institutions":[{"id":"https://openalex.org/I4210147129","display_name":"BrainAid (United States)","ror":"https://ror.org/04k00np26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacek B. Cywinski","raw_affiliation_strings":["BrainXAI Research, BrainX,LLC., Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0001-6283-3049","affiliations":[{"raw_affiliation_string":"BrainXAI Research, BrainX,LLC., Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210147129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047322462","display_name":"Francis Papay","orcid":"https://orcid.org/0000-0003-0455-2892"},"institutions":[{"id":"https://openalex.org/I4210147129","display_name":"BrainAid (United States)","ror":"https://ror.org/04k00np26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis Papay","raw_affiliation_strings":["BrainXAI Research, BrainX,LLC., Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-0455-2892","affiliations":[{"raw_affiliation_string":"BrainXAI Research, BrainX,LLC., Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210147129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047911401","display_name":"Kamal Maheshwari","orcid":"https://orcid.org/0000-0003-1961-5577"},"institutions":[{"id":"https://openalex.org/I4210147129","display_name":"BrainAid (United States)","ror":"https://ror.org/04k00np26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kamal Maheshwar","raw_affiliation_strings":["BrainXAI Research, BrainX,LLC., Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-1961-5577","affiliations":[{"raw_affiliation_string":"BrainXAI Research, BrainX,LLC., Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210147129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101848703","display_name":"Ashish K. Khanna","orcid":"https://orcid.org/0000-0002-9083-891X"},"institutions":[{"id":"https://openalex.org/I4210147129","display_name":"BrainAid (United States)","ror":"https://ror.org/04k00np26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashish K Khanna","raw_affiliation_strings":["BrainXAI Research, BrainX,LLC., Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0002-9083-891X","affiliations":[{"raw_affiliation_string":"BrainXAI Research, BrainX,LLC., Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210147129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050110511","display_name":"Piyush Mathur","orcid":"https://orcid.org/0000-0003-3777-8767"},"institutions":[{"id":"https://openalex.org/I4210147129","display_name":"BrainAid (United States)","ror":"https://ror.org/04k00np26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Piyush Mathur","raw_affiliation_strings":["BrainXAI Research, BrainX,LLC., Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-3777-8767","affiliations":[{"raw_affiliation_string":"BrainXAI Research, BrainX,LLC., Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210147129"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5045360539"],"corresponding_institution_ids":["https://openalex.org/I4210147129"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31096769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.635200023651123,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.635200023651123,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.1770000010728836,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10028","display_name":"Topic Modeling","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/health-care","display_name":"Health care","score":0.6474999785423279},{"id":"https://openalex.org/keywords/variety","display_name":"Variety (cybernetics)","score":0.6115000247955322},{"id":"https://openalex.org/keywords/adversarial-system","display_name":"Adversarial system","score":0.5123999714851379},{"id":"https://openalex.org/keywords/interpretation","display_name":"Interpretation (philosophy)","score":0.47290000319480896},{"id":"https://openalex.org/keywords/guideline","display_name":"Guideline","score":0.4571000039577484},{"id":"https://openalex.org/keywords/multidisciplinary-approach","display_name":"Multidisciplinary approach","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.6474999785423279},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6233000159263611},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.6115000247955322},{"id":"https://openalex.org/C37736160","wikidata":"https://www.wikidata.org/wiki/Q1801315","display_name":"Adversarial system","level":2,"score":0.5123999714851379},{"id":"https://openalex.org/C527412718","wikidata":"https://www.wikidata.org/wiki/Q855395","display_name":"Interpretation (philosophy)","level":2,"score":0.47290000319480896},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.4571000039577484},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.44929999113082886},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.3540000021457672},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.3206000030040741},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.31220000982284546},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C137293760","wikidata":"https://www.wikidata.org/wiki/Q3621696","display_name":"Language model","level":2,"score":0.2879999876022339},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28610000014305115},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2827000021934509},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.2703999876976013},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.25929999351501465},{"id":"https://openalex.org/C2776187449","wikidata":"https://www.wikidata.org/wiki/Q1513879","display_name":"Natural language generation","level":3,"score":0.25440001487731934}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3768322.3769017","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3768322.3769017","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Companion Proceedings of the 16th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1994307831","https://openalex.org/W3172996796","https://openalex.org/W3194710570","https://openalex.org/W4231576061","https://openalex.org/W4388725043","https://openalex.org/W4399238566","https://openalex.org/W4399329591","https://openalex.org/W4402369854","https://openalex.org/W4402813148","https://openalex.org/W4409505176"],"related_works":[],"abstract_inverted_index":{"Healthcare":[0],"guidelines":[1,103],"provide":[2],"evidence-based":[3],"recommendations":[4],"for":[5,80],"disease":[6],"management,":[7],"but":[8,30],"their":[9],"complexity":[10],"can":[11],"make":[12],"interpretation":[13],"challenging":[14],"in":[15,85],"patient-specific":[16],"contexts.":[17],"Large":[18],"Language":[19],"Models":[20],"(LLMs)":[21],"have":[22,48],"been":[23,49],"proposed":[24],"to":[25,40,51,65,134],"help":[26],"query":[27],"such":[28],"guidelines,":[29,61],"they":[31],"may":[32],"produce":[33],"inaccurate":[34],"or":[35],"incomplete":[36],"responses":[37],"when":[38],"applied":[39],"clinical":[41],"tasks.":[42],"Retrieval-Augmented":[43,156],"Generation":[44,157],"(RAG)":[45,158],"methods,":[46],"which":[47],"utilized":[50],"enhance":[52],"LLM":[53],"performance":[54,142],"by":[55,123],"incorporating":[56],"relevant":[57],"excerpts":[58],"from":[59],"healthcare":[60,81],"represent":[62],"one":[63],"strategy":[64],"improve":[66],"the":[67,136,141],"accuracy.":[68],"In":[69],"this":[70],"study,":[71],"we":[72,90,139,161],"present":[73],"a":[74,93,115,125,163],"threefold":[75],"contribution":[76],"toward":[77],"evaluating":[78],"LLMs":[79],"guideline":[82],"interpretation.":[83],"First,":[84],"collaboration":[86],"with":[87],"board-certified":[88],"physicians,":[89,124],"developed":[91],"GuidelineQA,":[92],"clinically":[94],"curated,":[95],"in-house":[96],"question-answer":[97],"dataset":[98,113],"covering":[99],"three":[100],"widely":[101],"used":[102],"on":[104],"cardiovascular":[105],"disease,":[106],"diabetes,":[107],"and":[108,130,148,155,172],"colon":[109],"cancer":[110],"prevention.":[111],"The":[112],"includes":[114],"variety":[116],"of":[117,143],"questions,":[118],"including":[119],"those":[120],"commonly":[121],"needed":[122],"frequently":[126],"asked":[127],"patient":[128],"question,":[129],"adversarial":[131],"questions":[132],"designed":[133],"challenge":[135],"LLMs.":[137],"Second,":[138],"assessed":[140],"two":[144],"state-of-the-art":[145],"models\u2014GPT-4o":[146],"(closed-source)":[147],"LLaMA-2-7B":[149],"(open-source)":[150],"under":[151],"both":[152,167],"standard":[153],"(non-augmented)":[154],"settings.":[159],"Third,":[160],"conducted":[162],"comprehensive":[164],"evaluation":[165],"using":[166],"quantitative":[168],"metrics":[169],"(e.g.,":[170],"BERTScore)":[171],"qualitative":[173],"human":[174],"assessments.":[175]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-12-05T00:00:00"}