{"id":"https://openalex.org/W4417200318","doi":"https://doi.org/10.1145/3765612.3767787","title":"Investigating Pace of Biological Aging as a Mental and Physical Health Biomarker in Youth with Perinatally-Acquired HIV","display_name":"Investigating Pace of Biological Aging as a Mental and Physical Health Biomarker in Youth with Perinatally-Acquired HIV","publication_year":2025,"publication_date":"2025-10-12","ids":{"openalex":"https://openalex.org/W4417200318","doi":"https://doi.org/10.1145/3765612.3767787"},"language":null,"primary_location":{"id":"doi:10.1145/3765612.3767787","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3765612.3767787","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 16th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048258795","display_name":"Hansoo Chang","orcid":"https://orcid.org/0000-0002-6882-3455"},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hansoo Chang","raw_affiliation_strings":["Drexel University, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-6882-3455","affiliations":[{"raw_affiliation_string":"Drexel University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ashni Kumar","orcid":"https://orcid.org/0009-0006-4337-1890"},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashni Kumar","raw_affiliation_strings":["Drexel University, Philadelphia, USA"],"raw_orcid":"https://orcid.org/0009-0006-4337-1890","affiliations":[{"raw_affiliation_string":"Drexel University, Philadelphia, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112083343","display_name":"Jae Hee Suh","orcid":"https://orcid.org/0009-0005-8360-9202"},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Suh","raw_affiliation_strings":["Drexel University, Philadelphia, USA"],"raw_orcid":"https://orcid.org/0009-0005-8360-9202","affiliations":[{"raw_affiliation_string":"Drexel University, Philadelphia, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109024713","display_name":"Kevin Street","orcid":"https://orcid.org/0009-0009-2297-8257"},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Street","raw_affiliation_strings":["Drexel University, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0009-0009-2297-8257","affiliations":[{"raw_affiliation_string":"Drexel University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093025491","display_name":"Ana Ferariu","orcid":"https://orcid.org/0009-0007-0035-6209"},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Ferariu","raw_affiliation_strings":["Drexel University, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0009-0007-0035-6209","affiliations":[{"raw_affiliation_string":"Drexel University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037788148","display_name":"Alexei Taylor","orcid":"https://orcid.org/0000-0003-4190-4658"},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexei Taylor","raw_affiliation_strings":["Drexel University, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4190-4658","affiliations":[{"raw_affiliation_string":"Drexel University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056422504","display_name":"Kunjal Patel","orcid":"https://orcid.org/0000-0003-0002-681X"},"institutions":[{"id":"https://openalex.org/I2801851002","display_name":"Harvard University Press","ror":"https://ror.org/006v7bf86","country_code":"US","type":"other","lineage":["https://openalex.org/I136199984","https://openalex.org/I2801851002"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kunjal Patel","raw_affiliation_strings":["Harvard University, Boston, USA"],"raw_orcid":"https://orcid.org/0000-0003-0002-681X","affiliations":[{"raw_affiliation_string":"Harvard University, Boston, USA","institution_ids":["https://openalex.org/I2801851002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061800035","display_name":"Sean S. Brummel","orcid":"https://orcid.org/0000-0002-4116-404X"},"institutions":[{"id":"https://openalex.org/I2801851002","display_name":"Harvard University Press","ror":"https://ror.org/006v7bf86","country_code":"US","type":"other","lineage":["https://openalex.org/I136199984","https://openalex.org/I2801851002"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Brummel","raw_affiliation_strings":["Harvard University, Boston, USA"],"raw_orcid":"https://orcid.org/0000-0002-4116-404X","affiliations":[{"raw_affiliation_string":"Harvard University, Boston, USA","institution_ids":["https://openalex.org/I2801851002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030452461","display_name":"Paige L. Williams","orcid":"https://orcid.org/0000-0002-7160-574X"},"institutions":[{"id":"https://openalex.org/I2801851002","display_name":"Harvard University Press","ror":"https://ror.org/006v7bf86","country_code":"US","type":"other","lineage":["https://openalex.org/I136199984","https://openalex.org/I2801851002"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paige Williams","raw_affiliation_strings":["Harvard University, Boston, USA"],"raw_orcid":"https://orcid.org/0000-0002-7160-574X","affiliations":[{"raw_affiliation_string":"Harvard University, Boston, USA","institution_ids":["https://openalex.org/I2801851002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435921","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0002-4230-9490"},"institutions":[{"id":"https://openalex.org/I2802437833","display_name":"Baycrest Hospital","ror":"https://ror.org/03gp5b411","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802437833"]},{"id":"https://openalex.org/I4405263474","display_name":"Rotman Research Institute","ror":"https://ror.org/01kvpec59","country_code":"CA","type":"education","lineage":["https://openalex.org/I4405258058","https://openalex.org/I4405263474"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Rotman Research Institute at Baycrest, Toronto, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4230-9490","affiliations":[{"raw_affiliation_string":"Rotman Research Institute at Baycrest, Toronto, Canada","institution_ids":["https://openalex.org/I2802437833","https://openalex.org/I4405263474"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072577919","display_name":"Fengqing Zhang","orcid":"https://orcid.org/0000-0003-2736-2303"},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fengqing Zhang","raw_affiliation_strings":["Drexel Univeresity, Philadelphia, USA"],"raw_orcid":"https://orcid.org/0000-0003-2736-2303","affiliations":[{"raw_affiliation_string":"Drexel Univeresity, Philadelphia, USA","institution_ids":["https://openalex.org/I72816309"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.3174000084400177,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.3174000084400177,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.16539999842643738,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.15960000455379486,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pace","display_name":"Pace","score":0.8698999881744385},{"id":"https://openalex.org/keywords/biological-age","display_name":"Biological age","score":0.7208999991416931},{"id":"https://openalex.org/keywords/metric","display_name":"Metric (unit)","score":0.6141999959945679},{"id":"https://openalex.org/keywords/healthy-aging","display_name":"Healthy aging","score":0.5293999910354614},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.46619999408721924},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.43479999899864197},{"id":"https://openalex.org/keywords/mental-health","display_name":"Mental health","score":0.41290000081062317},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4066999852657318}],"concepts":[{"id":"https://openalex.org/C2777526511","wikidata":"https://www.wikidata.org/wiki/Q691543","display_name":"Pace","level":2,"score":0.8698999881744385},{"id":"https://openalex.org/C2991747559","wikidata":"https://www.wikidata.org/wiki/Q4915075","display_name":"Biological age","level":2,"score":0.7208999991416931},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.6141999959945679},{"id":"https://openalex.org/C3017819807","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy aging","level":2,"score":0.5293999910354614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5218999981880188},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.46619999408721924},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.43479999899864197},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.41290000081062317},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.40959998965263367},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4066999852657318},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.4027999937534332},{"id":"https://openalex.org/C2778175527","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Successful aging","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.3021000027656555},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.29679998755455017},{"id":"https://openalex.org/C13774568","wikidata":"https://www.wikidata.org/wiki/Q439112","display_name":"Population ageing","level":3,"score":0.29280000925064087},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.263700008392334},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.2547999918460846},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.25429999828338623},{"id":"https://openalex.org/C2993280860","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Physical health","level":3,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3765612.3767787","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3765612.3767787","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 16th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2126104386"],"related_works":[],"abstract_inverted_index":{"HIV":[0,24,184],"and":[1,8,13,46,147,187,196],"its":[2],"treatment":[3],"may":[4,233],"affect":[5],"the":[6,14,75,98,107,117,172,225],"growth":[7],"development":[9],"of":[10,17,44,77,109,116,120,131,143,198,212,215,224,229,241],"organ":[11],"function":[12],"mental":[15,47],"health":[16,48,164,189,227],"youth":[18],"who":[19],"are":[20],"living":[21],"with":[22,68,90,182],"perinatally-acquired":[23],"(PHIV).":[25],"Recent":[26],"research":[27],"has":[28],"investigated":[29,74],"utilizing":[30,220],"biological":[31,60,78,84,110,132,144,148,194],"age":[32,61,149],"as":[33,66,112,140,166,169,237],"a":[34,41,55,102,113,207,221,238],"quantitative":[35],"tool":[36,240],"that":[37,177,232],"can":[38],"accurately":[39],"predict":[40],"broad":[42],"range":[43],"physical":[45],"outcomes.":[49],"However,":[50],"few":[51],"studies":[52,72],"have":[53,73,87],"utilized":[54],"longitudinal":[56],"approach":[57,104],"to":[58,105,136,157],"analyze":[59],"in":[62,80,94,171],"targeted":[63],"populations":[64],"such":[65,139],"those":[67],"PHIV.":[69],"Even":[70],"fewer":[71],"trends":[76],"aging":[79,85,111,133,145,195,199,216],"children":[81],"since":[82],"most":[83],"algorithms":[86],"been":[88],"developed":[89],"an":[91],"older":[92],"population":[93],"mind.":[95],"To":[96],"fill":[97],"gap,":[99],"we":[100],"propose":[101],"new":[103],"quantify":[106],"pace":[108,130,142,197,214],"weighted":[114,222],"combination":[115,223],"temporal":[118],"trajectory":[119],"each":[121,161,230],"individual":[122,231],"biomarker.":[123],"The":[124],"resulting":[125],"metric":[126],"is":[127],"called":[128],"individualized":[129],"(IPOA).":[134],"Compared":[135],"existing":[137],"methods":[138],"Belsky's":[141],"(BPOA),":[146],"gap":[150],"(BAG),":[151],"our":[152,202],"proposed":[153,203],"IPOA":[154,178],"allows":[155,205],"researchers":[156],"effectively":[158],"account":[159],"for":[160,206,217],"participant's":[162],"baseline":[163],"condition":[165,228],"these":[167],"serve":[168],"weights":[170],"model.":[173],"Our":[174],"results":[175],"show":[176],"was":[179],"significantly":[180],"associated":[181],"future":[183],"viral":[185],"load":[186],"multiple":[188],"outcomes,":[190],"outperforming":[191],"previously":[192],"validated":[193],"methods.":[200],"Overall,":[201],"method":[204,211],"more":[208],"accurate,":[209],"data-driven":[210],"calculating":[213],"adolescents":[218],"by":[219],"starting":[226],"be":[234],"clinically":[235],"useful":[236],"predictive":[239],"whole":[242],"person":[243],"health.":[244]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-12-10T00:00:00"}