{"id":"https://openalex.org/W7117781589","doi":"https://doi.org/10.1145/3761712.3761720","title":"Sex Dependency of Nonlinear Cerebrovascular CO2 Reactivity in the Postural Orthostatic Tachycardia Syndrome (POTS)","display_name":"Sex Dependency of Nonlinear Cerebrovascular CO2 Reactivity in the Postural Orthostatic Tachycardia Syndrome (POTS)","publication_year":2025,"publication_date":"2025-05-16","ids":{"openalex":"https://openalex.org/W7117781589","doi":"https://doi.org/10.1145/3761712.3761720"},"language":null,"primary_location":{"id":"doi:10.1145/3761712.3761720","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3761712.3761720","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2025 9th International Conference on Medical and Health Informatics","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090910395","display_name":"Shyan\u2010Lung Lin","orcid":"https://orcid.org/0000-0001-6316-4297"},"institutions":[{"id":"https://openalex.org/I4880106","display_name":"Feng Chia University","ror":"https://ror.org/05vhczg54","country_code":"TW","type":"education","lineage":["https://openalex.org/I4880106"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shyan-Lung Lin","raw_affiliation_strings":["Dept. of Automatic Control Eng., Feng Chia University, Taichung, Taiwan, Taichung, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-6316-4297","affiliations":[{"raw_affiliation_string":"Dept. of Automatic Control Eng., Feng Chia University, Taichung, Taiwan, Taichung, Taiwan","institution_ids":["https://openalex.org/I4880106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121620317","display_name":"Chia-Ju Shen","orcid":null},"institutions":[{"id":"https://openalex.org/I4880106","display_name":"Feng Chia University","ror":"https://ror.org/05vhczg54","country_code":"TW","type":"education","lineage":["https://openalex.org/I4880106"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Ju Shen","raw_affiliation_strings":["Dept. of Automatic Control Eng., Feng Chia University, Taichung, Taiwan, Taichung, Taiwan"],"raw_orcid":"https://orcid.org/0009-0005-9357-9334","affiliations":[{"raw_affiliation_string":"Dept. of Automatic Control Eng., Feng Chia University, Taichung, Taiwan, Taichung, Taiwan","institution_ids":["https://openalex.org/I4880106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108036391","display_name":"Shoou-Jeng Yeh","orcid":"https://orcid.org/0000-0002-8717-3689"},"institutions":[{"id":"https://openalex.org/I4210165149","display_name":"Cheng Ching Hospital","ror":"https://ror.org/05eqycp84","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210165149"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shoou-Jeng Yeh","raw_affiliation_strings":["Dept. of Neurology, Cheng Ching Hospital, Taichung, Taiwan, Taichung, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-8717-3689","affiliations":[{"raw_affiliation_string":"Dept. of Neurology, Cheng Ching Hospital, Taichung, Taiwan, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210165149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121660734","display_name":"Ching-Kun Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I4880106","display_name":"Feng Chia University","ror":"https://ror.org/05vhczg54","country_code":"TW","type":"education","lineage":["https://openalex.org/I4880106"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ching-Kun Chen","raw_affiliation_strings":["Dept. of Automatic Control Eng., Feng Chia University, Taichung, Taiwan, Taichung, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-4156-442X","affiliations":[{"raw_affiliation_string":"Dept. of Automatic Control Eng., Feng Chia University, Taichung, Taiwan, Taichung, Taiwan","institution_ids":["https://openalex.org/I4880106"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013161571","display_name":"Han\u2010Lin Tsai","orcid":"https://orcid.org/0000-0002-6698-7907"},"institutions":[{"id":"https://openalex.org/I4880106","display_name":"Feng Chia University","ror":"https://ror.org/05vhczg54","country_code":"TW","type":"education","lineage":["https://openalex.org/I4880106"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Han-Lin Tsai","raw_affiliation_strings":["Dept. of Automatic Control Eng., Feng Chia University, Taichung, Taiwan, Taichung, Taiwan"],"raw_orcid":"https://orcid.org/0009-0005-0692-0507","affiliations":[{"raw_affiliation_string":"Dept. of Automatic Control Eng., Feng Chia University, Taichung, Taiwan, Taichung, Taiwan","institution_ids":["https://openalex.org/I4880106"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71912014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"41","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.6664000153541565,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.6664000153541565,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.08760000020265579,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":0.06800000369548798,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-autoregulation","display_name":"Cerebral autoregulation","score":0.7060999870300293},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"Cerebral blood flow","score":0.5866000056266785},{"id":"https://openalex.org/keywords/orthostatic-vital-signs","display_name":"Orthostatic vital signs","score":0.522599995136261},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.43950000405311584},{"id":"https://openalex.org/keywords/postural-orthostatic-tachycardia-syndrome","display_name":"Postural Orthostatic Tachycardia Syndrome","score":0.34630000591278076}],"concepts":[{"id":"https://openalex.org/C84359808","wikidata":"https://www.wikidata.org/wiki/Q13365173","display_name":"Cerebral autoregulation","level":4,"score":0.7060999870300293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6690000295639038},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.5866000056266785},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5864999890327454},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5763000249862671},{"id":"https://openalex.org/C73787029","wikidata":"https://www.wikidata.org/wiki/Q7104929","display_name":"Orthostatic vital signs","level":3,"score":0.522599995136261},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.43950000405311584},{"id":"https://openalex.org/C2910439992","wikidata":"https://www.wikidata.org/wiki/Q620760","display_name":"Postural Orthostatic Tachycardia Syndrome","level":4,"score":0.34630000591278076},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.26930001378059387}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3761712.3761720","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3761712.3761720","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2025 9th International Conference on Medical and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1992239314","https://openalex.org/W2007441896","https://openalex.org/W2066357153","https://openalex.org/W2153425956","https://openalex.org/W2164650922","https://openalex.org/W2168261002","https://openalex.org/W4293515308","https://openalex.org/W4392255498"],"related_works":[],"abstract_inverted_index":{"Diabetes":[0],"Mellitus":[1],"(DM)":[2],"is":[3],"a":[4,13,36,91,170],"leading":[5],"cause":[6],"of":[7,66,123,130,134,150,173,184],"cardiovascular":[8],"diseases":[9],"that":[10],"affects":[11],"over":[12],"hundred":[14],"million":[15],"people":[16],"worldwide,":[17],"and":[18,45,81,88,101,113,189,205],"patients":[19],"with":[20,90,116],"DM":[21,72,78,82,179],"are":[22,196],"also":[23],"known":[24],"to":[25,107,126,153,198],"have":[26,34],"significant":[27,139],"impairments":[28],"in":[29,56,121,141,148,162,178,208],"cerebral":[30,40,174,187],"autoregulation.":[31],"Previous":[32],"studies":[33,52],"shown":[35],"nonlinear":[37,99,171],"relationship":[38],"between":[39],"blood":[41,175],"flow":[42,176],"velocity":[43],"(CBFV)":[44],"end-tidal":[46],"carbon":[47,108],"dioxide":[48,109],"(PETCO2);":[49],"however,":[50],"past":[51],"were":[53,74,111],"primarily":[54],"conducted":[55],"stable":[57],"conditions":[58],"or":[59,145],"healthy":[60],"subjects,":[61],"let":[62],"alone":[63],"the":[64,117,124,131,135,143,151,156,164,182,191],"analysis":[65],"gender":[67,86],"differences.":[68,193],"In":[69],"this":[70],"article,":[71],"subjects":[73],"further":[75],"divided":[76],"into":[77],"males":[79],"(DM-M)":[80],"females":[83],"(DM-F)":[84],"through":[85],"classification":[87],"compared":[89],"normal":[92,118],"elder":[93,119],"group":[94,158],"(NE).":[95],"Under":[96],"hyperventilation,":[97],"gender-based":[98],"CBFV":[100,125],"CVCi":[102,152],"(cerebrovascular":[103],"conductance":[104],"index)":[105],"responses":[106],"(CO2)":[110],"analyzed":[112],"studied.":[114],"Compared":[115],"group,":[120],"terms":[122,149],"CO2":[127,154],"response,":[128,155],"three":[129],"four":[132,165],"parameters":[133],"sigmoid":[136],"function":[137],"showed":[138],"differences":[140,161],"either":[142],"DM-M":[144],"DM-F":[146,157],"group;":[147],"revealed":[159],"substantial":[160],"all":[163],"parameters.":[166],"This":[167],"study":[168],"provides":[169],"assessment":[172],"regulation":[177],"patients,":[180],"analyzing":[181],"impact":[183],"diabetes":[185],"on":[186],"autoregulation":[188],"exploring":[190],"gender-specific":[192,203],"The":[194],"findings":[195],"expected":[197],"offer":[199],"valuable":[200],"insights":[201],"for":[202],"evaluation":[204],"quantitative":[206],"diagnostics":[207],"clinical":[209],"settings.":[210]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-12-31T00:00:00"}