{"id":"https://openalex.org/W4415431133","doi":"https://doi.org/10.1145/3760544.3764130","title":"Entropy-driven Effective Tumor Detection using Nanoscale Medical Agents","display_name":"Entropy-driven Effective Tumor Detection using Nanoscale Medical Agents","publication_year":2025,"publication_date":"2025-10-22","ids":{"openalex":"https://openalex.org/W4415431133","doi":"https://doi.org/10.1145/3760544.3764130"},"language":"en","primary_location":{"id":"doi:10.1145/3760544.3764130","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3760544.3764130","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3760544.3764130","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 12th Annual ACM International Conference on Nanoscale Computing and Communication","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dl.acm.org/doi/pdf/10.1145/3760544.3764130","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120093173","display_name":"Bahram Hedayati","orcid":null},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Bahram Hedayati","raw_affiliation_strings":["Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy"],"raw_orcid":"https://orcid.org/0009-0008-7763-3443","affiliations":[{"raw_affiliation_string":"Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030598071","display_name":"Karthik Reddy Gorla","orcid":"https://orcid.org/0009-0008-3807-8328"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Karthik Reddy Gorla","raw_affiliation_strings":["Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy"],"raw_orcid":"https://orcid.org/0009-0008-3807-8328","affiliations":[{"raw_affiliation_string":"Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026125746","display_name":"Maurizio Magarini","orcid":"https://orcid.org/0000-0001-9288-0452"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Magarini","raw_affiliation_strings":["Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9288-0452","affiliations":[{"raw_affiliation_string":"Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I93860229"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15241379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"40","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.4837000072002411},{"id":"https://openalex.org/keywords/tumor-cells","display_name":"Tumor cells","score":0.48350000381469727},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4779999852180481},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.45260000228881836},{"id":"https://openalex.org/keywords/cancer-treatment","display_name":"Cancer treatment","score":0.45249998569488525},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4203000068664551},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"Chemotaxis","score":0.41359999775886536},{"id":"https://openalex.org/keywords/hypoxia","display_name":"Hypoxia (environmental)","score":0.41179999709129333}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4837000072002411},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.48350000381469727},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4779999852180481},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.45260000228881836},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.45249998569488525},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43689998984336853},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4203000068664551},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.41359999775886536},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.41179999709129333},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3937999904155731},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.37369999289512634},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.36230000853538513},{"id":"https://openalex.org/C2779081379","wikidata":"https://www.wikidata.org/wiki/Q7852677","display_name":"Tumor hypoxia","level":3,"score":0.3407999873161316},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.32670000195503235},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3260999917984009},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.29899999499320984},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.29679998755455017},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2849999964237213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2849000096321106},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.28450000286102295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2766000032424927},{"id":"https://openalex.org/C3020340455","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer drugs","level":3,"score":0.2761000096797943},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C45206210","wikidata":"https://www.wikidata.org/wiki/Q2415817","display_name":"Nanoscopic scale","level":2,"score":0.26910001039505005}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1145/3760544.3764130","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3760544.3764130","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3760544.3764130","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 12th Annual ACM International Conference on Nanoscale Computing and Communication","raw_type":"proceedings-article"},{"id":"pmh:oai:re.public.polimi.it:11311/1310605","is_oa":false,"landing_page_url":"https://hdl.handle.net/11311/1310605","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"doi:10.1145/3760544.3764130","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3760544.3764130","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3760544.3764130","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 12th Annual ACM International Conference on Nanoscale Computing and Communication","raw_type":"proceedings-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415431133.pdf","grobid_xml":"https://content.openalex.org/works/W4415431133.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1980661496","https://openalex.org/W1995875735","https://openalex.org/W2003495286","https://openalex.org/W2010638294","https://openalex.org/W2063081081","https://openalex.org/W2121421529","https://openalex.org/W2137634849","https://openalex.org/W2292016096","https://openalex.org/W2898858272","https://openalex.org/W2949331010","https://openalex.org/W2949797623","https://openalex.org/W2963874589","https://openalex.org/W3004230404","https://openalex.org/W3109757689","https://openalex.org/W3130910473","https://openalex.org/W4321021224","https://openalex.org/W4365449016","https://openalex.org/W4385483664","https://openalex.org/W4388275106","https://openalex.org/W4398214115","https://openalex.org/W4401576312","https://openalex.org/W4404700081"],"related_works":[],"abstract_inverted_index":{"Despite":[0],"advances":[1],"in":[2,18,103],"medical":[3,77],"research":[4],"and":[5,24,72,91,134,149],"therapy,":[6],"cancer":[7,32],"remains":[8],"a":[9,41,65,84],"major":[10],"global":[11],"health":[12],"issue":[13],"due":[14],"to":[15,52,74,88,106],"its":[16],"complexity":[17],"treatment.":[19],"Depending":[20],"on":[21],"the":[22,27,54,97,101,108,120,132,137,147,163,170],"type":[23],"extent":[25],"of":[26,56,100,136,146,155],"disease,":[28],"tumor":[29,85],"removal":[30],"with":[31],"treatment":[33,57],"drugs":[34],"without":[35],"harming":[36],"surrounding":[37],"healthy":[38],"tissue":[39],"is":[40],"critical":[42],"challenge.":[43],"The":[44,94,127],"targeted":[45],"drug":[46],"delivery":[47],"(TDD)":[48],"approach":[49],"has":[50],"emerged":[51],"increase":[53],"effectiveness":[55,133],"while":[58],"reducing":[59],"side":[60],"effects.":[61],"This":[62],"paper":[63],"envisions":[64],"hybrid":[66,138],"navigation":[67,139,151],"mechanism":[68],"that":[69,131,162],"utilizes":[70],"chemotaxis":[71,150],"entropy":[73],"direct":[75],"nanoscale":[76],"agents":[78],"(NMAs)":[79],"toward":[80],"cancerous":[81,125,156],"cells":[82],"within":[83],"microenvironment":[86],"(TME)":[87],"release":[89],"medication":[90],"treat":[92],"them.":[93],"NMAs":[95],"sense":[96],"concentration":[98],"gradient":[99],"biomarkers":[102],"their":[104],"vicinity":[105],"localize":[107],"tumor(s).":[109],"For":[110],"this":[111],"study,":[112],"we":[113],"used":[114],"hypoxia":[115],"as":[116],"our":[117],"biomarker,":[118],"given":[119],"higher":[121,143],"oxygen":[122],"consumption":[123],"by":[124],"cells.":[126],"numerical":[128],"results":[129],"show":[130],"reliability":[135],"strategy":[140],"are":[141],"significantly":[142],"than":[144,169],"those":[145],"random":[148],"mechanisms.":[152],"Furthermore,":[153],"analysis":[154],"cell":[157],"statistics":[158],"over":[159],"time":[160],"demonstrates":[161],"proposed":[164],"method":[165],"eliminates":[166],"tumors":[167],"faster":[168],"other":[171],"two":[172],"strategies.":[173]},"counts_by_year":[],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-24T00:00:00"}