{"id":"https://openalex.org/W4411489267","doi":"https://doi.org/10.1145/3745022","title":"Genomics-Enhanced Cancer Risk Prediction for Personalized LLM-Driven Healthcare Recommender Systems","display_name":"Genomics-Enhanced Cancer Risk Prediction for Personalized LLM-Driven Healthcare Recommender Systems","publication_year":2025,"publication_date":"2025-06-20","ids":{"openalex":"https://openalex.org/W4411489267","doi":"https://doi.org/10.1145/3745022"},"language":"en","primary_location":{"id":"doi:10.1145/3745022","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3745022","pdf_url":null,"source":{"id":"https://openalex.org/S4394735545","display_name":"ACM Transactions on Information Systems","issn_l":"1046-8188","issn":["1046-8188","1558-2868"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACM Transactions on Information Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021877509","display_name":"Kezhi Lu","orcid":"https://orcid.org/0000-0003-4979-5097"},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Kezhi Lu","raw_affiliation_strings":["Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","University of Technology Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0003-4979-5097","affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]},{"raw_affiliation_string":"University of Technology Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100675577","display_name":"Jie L\u00fc","orcid":"https://orcid.org/0000-0003-0690-4732"},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jie Lu","raw_affiliation_strings":["Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","University of Technology Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0003-0690-4732","affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]},{"raw_affiliation_string":"University of Technology Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064251243","display_name":"Hanshi Xu","orcid":"https://orcid.org/0000-0003-1129-5337"},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hanshi Xu","raw_affiliation_strings":["Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","University of Technology Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0003-1129-5337","affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]},{"raw_affiliation_string":"University of Technology Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089905899","display_name":"Kairui Guo","orcid":"https://orcid.org/0000-0003-1570-314X"},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kairui Guo","raw_affiliation_strings":["Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","University of Technology Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0003-1570-314X","affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]},{"raw_affiliation_string":"University of Technology Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101503948","display_name":"Qian Zhang","orcid":"https://orcid.org/0000-0001-9977-8418"},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Qian Zhang","raw_affiliation_strings":["Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","University of Technology Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0001-9977-8418","affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]},{"raw_affiliation_string":"University of Technology Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hua Lin","orcid":"https://orcid.org/0009-0005-5111-4627"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hua Lin","raw_affiliation_strings":["23Strands Pty Ltd, Sydney, Australia","23Strands Pty Ltd, Australia"],"raw_orcid":"https://orcid.org/0009-0005-5111-4627","affiliations":[{"raw_affiliation_string":"23Strands Pty Ltd, Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"23Strands Pty Ltd, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024113714","display_name":"Mark Grosser","orcid":"https://orcid.org/0000-0002-4281-5369"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark Grosser","raw_affiliation_strings":["23Strands Pty Ltd, Sydney, Australia","23Strands Pty Ltd, Australia"],"raw_orcid":"https://orcid.org/0000-0002-4281-5369","affiliations":[{"raw_affiliation_string":"23Strands Pty Ltd, Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"23Strands Pty Ltd, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388218","display_name":"Yi Zhang","orcid":"https://orcid.org/0000-0002-7731-0301"},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","University of Technology Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0002-7731-0301","affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]},{"raw_affiliation_string":"University of Technology Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062192039","display_name":"Guangquan Zhang","orcid":"https://orcid.org/0000-0003-3960-0583"},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Guangquan Zhang","raw_affiliation_strings":["Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","University of Technology Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0003-3960-0583","affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]},{"raw_affiliation_string":"University of Technology Sydney, Australia","institution_ids":["https://openalex.org/I114017466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5021877509"],"corresponding_institution_ids":["https://openalex.org/I114017466"],"apc_list":null,"apc_paid":null,"fwci":3.288,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.92276423,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"43","issue":"6","first_page":"1","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9825999736785889,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biobank","display_name":"Biobank","score":0.6054291129112244},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6051830649375916},{"id":"https://openalex.org/keywords/health-care","display_name":"Health care","score":0.5460701584815979},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.5326732397079468},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.46113765239715576},{"id":"https://openalex.org/keywords/predictive-modelling","display_name":"Predictive modelling","score":0.4570302367210388},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"Risk assessment","score":0.426188200712204},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.40159133076667786},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.3663415312767029},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3633280396461487},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.33770740032196045},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.33042246103286743},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.25040945410728455},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22839677333831787},{"id":"https://openalex.org/keywords/computer-security","display_name":"Computer security","score":0.12868312001228333}],"concepts":[{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.6054291129112244},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6051830649375916},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.5460701584815979},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.5326732397079468},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.46113765239715576},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.4570302367210388},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.426188200712204},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40159133076667786},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3663415312767029},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3633280396461487},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33770740032196045},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.33042246103286743},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25040945410728455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22839677333831787},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.12868312001228333},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3745022","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3745022","pdf_url":null,"source":{"id":"https://openalex.org/S4394735545","display_name":"ACM Transactions on Information Systems","issn_l":"1046-8188","issn":["1046-8188","1558-2868"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACM Transactions on Information Systems","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.44999998807907104,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1983835681","https://openalex.org/W2012944782","https://openalex.org/W2029065216","https://openalex.org/W2064675550","https://openalex.org/W2082704080","https://openalex.org/W2088752888","https://openalex.org/W2112796928","https://openalex.org/W2114005874","https://openalex.org/W2155858420","https://openalex.org/W2165664908","https://openalex.org/W2282821441","https://openalex.org/W2345958530","https://openalex.org/W2767278854","https://openalex.org/W2803332630","https://openalex.org/W2803760365","https://openalex.org/W2901952863","https://openalex.org/W2962039734","https://openalex.org/W3014994762","https://openalex.org/W3039125152","https://openalex.org/W3083488708","https://openalex.org/W3134721632","https://openalex.org/W3204312334","https://openalex.org/W4220858968","https://openalex.org/W4223567842","https://openalex.org/W4292622945","https://openalex.org/W4315779631","https://openalex.org/W4382700964","https://openalex.org/W4386498736","https://openalex.org/W4388953020","https://openalex.org/W4394877201"],"related_works":["https://openalex.org/W4404536308","https://openalex.org/W2238249811","https://openalex.org/W3082935376","https://openalex.org/W3015000613","https://openalex.org/W4399651953","https://openalex.org/W4386960999","https://openalex.org/W2899657781","https://openalex.org/W4322484660","https://openalex.org/W3193951088","https://openalex.org/W4388011470"],"abstract_inverted_index":{"Cancer":[0],"risk":[1,27,131,185,193],"prediction":[2,80,132,186,194],"is":[3,58],"a":[4,114,129,201],"cornerstone":[5],"of":[6,44,55,110,144],"personalized":[7,137],"medicine":[8],"that":[9,179],"offers":[10],"opportunities":[11],"for":[12,134,161,212],"early":[13,214],"detection":[14,215],"and":[15,49,127,136,148,167,195,217,224],"preventive":[16,219],"interventions.":[17],"However,":[18],"the":[19,42,53,61,84,124,142,165,168,190],"current":[20],"models":[21,57,62,151],"are":[22,226],"designed":[23,128],"to":[24,40,64,99],"predict":[25,88],"cancer":[26,101,135,184],"face":[28],"several":[29],"challenges.":[30],"First,":[31],"most":[32],"rely":[33],"on":[34,116,174],"traditional":[35],"statistical":[36],"methods,":[37],"which":[38,77],"struggle":[39],"capture":[41],"complexity":[43],"genetic,":[45],"family":[46],"medical":[47],"history,":[48],"lifestyle":[50],"factors.":[51],"Hence,":[52],"accuracy":[54],"these":[56,111],"limited.":[59],"Additionally,":[60],"neglect":[63],"integrate":[65],"multidimensional":[66],"data":[67,122,177,225],"sources,":[68],"particularly":[69],"genetic":[70],"information":[71],"like":[72],"single":[73],"nucleotide":[74],"polymorphisms":[75],"(SNPs),":[76],"could":[78],"enhance":[79],"accuracy.":[81],"Third,":[82],"while":[83],"system":[85,204],"might":[86],"effectively":[87],"risk,":[89],"it":[90],"cannot":[91],"translate":[92],"those":[93],"predictions":[94],"into":[95],"actionable":[96],"healthcare":[97,138,197,202,220],"recommendations":[98,139],"reduce":[100],"risk.":[102],"In":[103],"this":[104],"study,":[105],"we":[106,199],"address":[107],"all":[108],"three":[109],"limitations.":[112],"With":[113],"focus":[115],"six":[117],"prevalent":[118],"cancers\u2014we":[119],"extracted":[120],"SNP":[121],"from":[123],"UK":[125,175],"Biobank":[126,176],"novel":[130],"model":[133,181],"based":[140,157],"upon":[141],"mixture":[143],"experts":[145,156],"(MoE)":[146],"paradigm":[147],"large":[149],"language":[150],"(LLMs),":[152],"respectively.":[153],"Named":[154],"MoE-HRS,":[155],"two":[158],"router":[159],"networks":[160],"separate":[162],"processing":[163],"by":[164,206],"Transformer":[166],"convolutional":[169],"neural":[170],"network":[171],"(CNN).":[172],"Experiments":[173],"show":[178],"our":[180],"outperforms":[182],"state-of-the-art":[183],"models.":[187],"To":[188],"bridge":[189],"gap":[191],"between":[192],"practical":[196],"applications,":[198],"devised":[200],"recommender":[203],"powered":[205],"LLMs.":[207],"This":[208],"approach":[209],"holds":[210],"promise":[211],"enhancing":[213],"rates":[216],"promoting":[218],"management":[221],"(relevant":[222],"coding":[223],"available":[227],"at":[228],"https://github.com/bjtu-lucas-nlp/MoE-HRS":[229],").":[230]},"counts_by_year":[{"year":2025,"cited_by_count":4}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-06-21T00:00:00"}
