{"id":"https://openalex.org/W4411029052","doi":"https://doi.org/10.1145/3715020.3715055","title":"Discovering Effective DNA Methylation Biomarkers through Different Gene Mutation Groups for Lung Cancer Detection","display_name":"Discovering Effective DNA Methylation Biomarkers through Different Gene Mutation Groups for Lung Cancer Detection","publication_year":2024,"publication_date":"2024-11-28","ids":{"openalex":"https://openalex.org/W4411029052","doi":"https://doi.org/10.1145/3715020.3715055"},"language":"en","primary_location":{"id":"doi:10.1145/3715020.3715055","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3715020.3715055","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3715020.3715055","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 8th International Conference on Computational Biology and Bioinformatics","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dl.acm.org/doi/pdf/10.1145/3715020.3715055","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102096285","display_name":"Huan-Zhi Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I118292597","display_name":"National Taipei University of Technology","ror":"https://ror.org/00cn92c09","country_code":"TW","type":"education","lineage":["https://openalex.org/I118292597"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Huan-Zhi Lin","raw_affiliation_strings":["Dept. of Computer Science and Informational Engineering, National Taipei University of Technology, Taipei, Taiwan"],"raw_orcid":"https://orcid.org/0009-0008-5589-1660","affiliations":[{"raw_affiliation_string":"Dept. of Computer Science and Informational Engineering, National Taipei University of Technology, Taipei, Taiwan","institution_ids":["https://openalex.org/I118292597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103620540","display_name":"S. C. HUANG","orcid":null},"institutions":[{"id":"https://openalex.org/I118292597","display_name":"National Taipei University of Technology","ror":"https://ror.org/00cn92c09","country_code":"TW","type":"education","lineage":["https://openalex.org/I118292597"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shi-Yan Huang","raw_affiliation_strings":["Dept. of Computer Science and Informational Engineering, National Taipei University of Technology, Taipei, Taiwan"],"raw_orcid":"https://orcid.org/0009-0007-6320-136X","affiliations":[{"raw_affiliation_string":"Dept. of Computer Science and Informational Engineering, National Taipei University of Technology, Taipei, Taiwan","institution_ids":["https://openalex.org/I118292597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086428506","display_name":"Tun\u2010Wen Pai","orcid":"https://orcid.org/0000-0002-2869-4169"},"institutions":[{"id":"https://openalex.org/I118292597","display_name":"National Taipei University of Technology","ror":"https://ror.org/00cn92c09","country_code":"TW","type":"education","lineage":["https://openalex.org/I118292597"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tun-Wen Pai","raw_affiliation_strings":["Dept. of Computer Science and Informational Engineering, National Taipei University of Technology, Taipei, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-2869-4169","affiliations":[{"raw_affiliation_string":"Dept. of Computer Science and Informational Engineering, National Taipei University of Technology, Taipei, Taiwan","institution_ids":["https://openalex.org/I118292597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007138823","display_name":"Dah-Tsyr Chang","orcid":null},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Dah-Tsyr Chang","raw_affiliation_strings":["Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":"https://orcid.org/0009-0007-0722-9114","affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100999334","display_name":"Yi-Hsuan Lai","orcid":null},"institutions":[{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Hsuan Lai","raw_affiliation_strings":["Dept. of Product Development, ACT Genomics Co., Ltd., Taipei, Taiwan"],"raw_orcid":"https://orcid.org/0009-0005-3815-4691","affiliations":[{"raw_affiliation_string":"Dept. of Product Development, ACT Genomics Co., Ltd., Taipei, Taiwan","institution_ids":["https://openalex.org/I4210087491"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37051753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"118","last_page":"125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6553230881690979},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5683795213699341},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5016412734985352},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.49775007367134094},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.49639207124710083},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4763489067554474},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.449144184589386},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.44730493426322937},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41051048040390015},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3588689863681793},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.34869974851608276},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2546582818031311},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.18914547562599182},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12888452410697937}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6553230881690979},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5683795213699341},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5016412734985352},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.49775007367134094},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.49639207124710083},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4763489067554474},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.449144184589386},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.44730493426322937},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41051048040390015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3588689863681793},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34869974851608276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2546582818031311},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.18914547562599182},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12888452410697937}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3715020.3715055","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3715020.3715055","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3715020.3715055","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 8th International Conference on Computational Biology and Bioinformatics","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1145/3715020.3715055","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3715020.3715055","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3715020.3715055","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 8th International Conference on Computational Biology and Bioinformatics","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.6600000262260437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3526465181","display_name":null,"funder_award_id":"NSTC 111-2622-E-027-021","funder_id":"https://openalex.org/F4320331164","funder_display_name":"National Science and Technology Council"}],"funders":[{"id":"https://openalex.org/F4320331164","display_name":"National Science and Technology Council","ror":"https://ror.org/00wnb9798"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411029052.pdf","grobid_xml":"https://content.openalex.org/works/W4411029052.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2074905514","https://openalex.org/W2084748297","https://openalex.org/W2104760300","https://openalex.org/W2142995543","https://openalex.org/W2324313493","https://openalex.org/W2540263083","https://openalex.org/W2778455075","https://openalex.org/W2797317586","https://openalex.org/W2805478465","https://openalex.org/W2950215225","https://openalex.org/W3191603129","https://openalex.org/W4206243212","https://openalex.org/W4312858211","https://openalex.org/W4362566809","https://openalex.org/W4367049439","https://openalex.org/W6691392362","https://openalex.org/W6790464081","https://openalex.org/W6959643953"],"related_works":["https://openalex.org/W2360682882","https://openalex.org/W2902329290","https://openalex.org/W2139872319","https://openalex.org/W2052355316","https://openalex.org/W2046964473","https://openalex.org/W2107880877","https://openalex.org/W2151182744","https://openalex.org/W2024490794","https://openalex.org/W1998349112","https://openalex.org/W2054863651"],"abstract_inverted_index":{"Lung":[0,24],"cancer":[1,16,25,50,77,150],"is":[2,18,26,133],"the":[3,11,42,58,92,102,176],"leading":[4],"causes":[5],"of":[6,13,48,142,166,195],"cancer-related":[7],"deaths":[8],"worldwide":[9],"and":[10,38,56,97,119,125,154,197],"number":[12],"new":[14],"lung":[15,49,76,149],"cases":[17],"continuously":[19],"increasing":[20],"for":[21,75,105,147],"both":[22],"sexes.":[23],"often":[27],"diagnosed":[28],"at":[29],"its":[30],"late":[31],"stages":[32],"when":[33],"disease":[34],"symptoms":[35],"become":[36],"apparent,":[37],"it":[39,198],"would":[40],"miss":[41],"optimal":[43],"treatment":[44,54],"options.":[45],"Early":[46],"detection":[47,145],"could":[51,199],"provide":[52],"early":[53,148],"options":[55],"improve":[57,157],"survival":[59,158],"rates.":[60,159],"This":[61],"study":[62,93],"focused":[63],"on":[64,81,123],"analyzing":[65],"genome-wide":[66],"methylation":[67,73,107,129,179],"differences":[68],"to":[69,100,134,138,156,202],"discover":[70],"suitable":[71],"DNA":[72,106],"biomarkers":[74],"subjects":[78],"mainly":[79],"based":[80],"mutations":[82],"occurred":[83],"in":[84],"EGFR,":[85],"KRAS,":[86],"or":[87,173],"TP53":[88,171],"genes.":[89],"In":[90],"addition,":[91],"applied":[94,201],"neural":[95],"network":[96],"deep":[98],"SHAP":[99],"identify":[101,135],"common":[103],"features":[104],"biomarker":[108,180],"selection.":[109],"The":[110,131,160],"prediction":[111,193],"models":[112],"were":[113],"constructed":[114],"employing":[115],"SVM,":[116],"Logistic":[117],"Regression,":[118],"XGBoost":[120],"kernel":[121],"techniques":[122],"cross-comparison":[124],"recommended":[126],"24":[127],"important":[128],"biomarkers.":[130],"goal":[132],"key":[136],"factors":[137],"pave":[139],"a":[140,143,191],"ground":[141],"non-invasive":[144],"toolkit":[146],"diagnosis":[151],"with":[152,190,208],"convenience":[153],"accuracy":[155,194,210],"results":[161],"have":[162],"shown":[163],"that":[164],"regardless":[165],"EGFR":[167],"mutations,":[168,170,172],"KRAS":[169],"normal":[174],"subjects,":[175],"best":[177],"selected":[178],"combinations":[181],"performed":[182],"very":[183],"well":[184,207],"across":[185],"various":[186],"machine":[187],"learning":[188],"models,":[189],"median":[192],"93%,":[196],"be":[200],"liquid":[203],"biopsy":[204],"samples":[205],"as":[206],"an":[209],"larger":[211],"than":[212],"80%.":[213]},"counts_by_year":[],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2025-10-10T00:00:00"}