{"id":"https://openalex.org/W4406677312","doi":"https://doi.org/10.1145/3714455","title":"Deep Generative Models for Therapeutic Peptide Discovery: A Comprehensive Review","display_name":"Deep Generative Models for Therapeutic Peptide Discovery: A Comprehensive Review","publication_year":2025,"publication_date":"2025-01-21","ids":{"openalex":"https://openalex.org/W4406677312","doi":"https://doi.org/10.1145/3714455"},"language":"en","primary_location":{"id":"doi:10.1145/3714455","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3714455","pdf_url":null,"source":{"id":"https://openalex.org/S157921468","display_name":"ACM Computing Surveys","issn_l":"0360-0300","issn":["0360-0300","1557-7341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319798","host_organization_name":"Association for Computing Machinery","host_organization_lineage":["https://openalex.org/P4310319798"],"host_organization_lineage_names":["Association for Computing Machinery"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACM Computing Surveys","raw_type":"journal-article"},"type":"review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109570641","display_name":"Liangtao Lai","orcid":null},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Leshan Lai","raw_affiliation_strings":["College of Information Science and Engineering, Hunan University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018620403","display_name":"Yuansheng Liu","orcid":"https://orcid.org/0000-0002-7680-3155"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuansheng Liu","raw_affiliation_strings":["College of Information Science and Engineering, Hunan University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034581482","display_name":"Bosheng Song","orcid":null},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bosheng Song","raw_affiliation_strings":["College of Information Science and Engineering, Hunan University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087894632","display_name":"Keqin Li","orcid":"https://orcid.org/0000-0001-5224-4048"},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keqin Li","raw_affiliation_strings":["Department of Computer Science, State University of New York, New York, United States"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, State University of New York, New York, United States","institution_ids":["https://openalex.org/I1327163397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027286013","display_name":"Xiangxiang Zeng","orcid":"https://orcid.org/0000-0001-6201-0114"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangxiang Zeng","raw_affiliation_strings":["College of Information Science and Engineering, Hunan University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5109570641"],"corresponding_institution_ids":["https://openalex.org/I16609230"],"apc_list":null,"apc_paid":null,"fwci":22.8764,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.99698424,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"57","issue":"6","first_page":"1","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.8454859256744385},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.6783934831619263},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4950393736362457},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.34579145908355713},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.33939599990844727}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.8454859256744385},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.6783934831619263},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4950393736362457},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.34579145908355713},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.33939599990844727}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3714455","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3714455","pdf_url":null,"source":{"id":"https://openalex.org/S157921468","display_name":"ACM Computing Surveys","issn_l":"0360-0300","issn":["0360-0300","1557-7341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319798","host_organization_name":"Association for Computing Machinery","host_organization_lineage":["https://openalex.org/P4310319798"],"host_organization_lineage_names":["Association for Computing Machinery"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACM Computing Surveys","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1334762759","display_name":null,"funder_award_id":"6212202","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G268992786","display_name":null,"funder_award_id":"U22A2037","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3090105490","display_name":null,"funder_award_id":"62272151","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4335622648","display_name":null,"funder_award_id":"6227215","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4652156585","display_name":null,"funder_award_id":"62372159, 62425204, 62122025, U22A2037, 62450002, 62432011, and 62272151","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5477186794","display_name":null,"funder_award_id":"62122025","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G635739521","display_name":null,"funder_award_id":"62372159","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6446245973","display_name":null,"funder_award_id":"62250028","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7307202658","display_name":null,"funder_award_id":"62172002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":145,"referenced_works":["https://openalex.org/W569478347","https://openalex.org/W1931581539","https://openalex.org/W1993845689","https://openalex.org/W1994048581","https://openalex.org/W1998931880","https://openalex.org/W2000330915","https://openalex.org/W2012251902","https://openalex.org/W2014274241","https://openalex.org/W2021488880","https://openalex.org/W2028339001","https://openalex.org/W2035755292","https://openalex.org/W2043816461","https://openalex.org/W2059874211","https://openalex.org/W2064675550","https://openalex.org/W2079735306","https://openalex.org/W2081306620","https://openalex.org/W2097099115","https://openalex.org/W2097398162","https://openalex.org/W2097834518","https://openalex.org/W2099153308","https://openalex.org/W2110485445","https://openalex.org/W2113617961","https://openalex.org/W2131275757","https://openalex.org/W2134378878","https://openalex.org/W2147454197","https://openalex.org/W2152380569","https://openalex.org/W2157331557","https://openalex.org/W2158714788","https://openalex.org/W2163316049","https://openalex.org/W2163922914","https://openalex.org/W2173520492","https://openalex.org/W2175270296","https://openalex.org/W2220780917","https://openalex.org/W2273267066","https://openalex.org/W2555630365","https://openalex.org/W2584676873","https://openalex.org/W2588463038","https://openalex.org/W2593390416","https://openalex.org/W2598922467","https://openalex.org/W2611281850","https://openalex.org/W2739980134","https://openalex.org/W2748987661","https://openalex.org/W2766736793","https://openalex.org/W2779119857","https://openalex.org/W2784920021","https://openalex.org/W2789857505","https://openalex.org/W2794956775","https://openalex.org/W2797108417","https://openalex.org/W2802224083","https://openalex.org/W2802730096","https://openalex.org/W2806146459","https://openalex.org/W2807001312","https://openalex.org/W2874062053","https://openalex.org/W2896869870","https://openalex.org/W2903545365","https://openalex.org/W2919115771","https://openalex.org/W2945669687","https://openalex.org/W2947548407","https://openalex.org/W2953641781","https://openalex.org/W2954996726","https://openalex.org/W2963223306","https://openalex.org/W2963248348","https://openalex.org/W2963341956","https://openalex.org/W2964024144","https://openalex.org/W2964268978","https://openalex.org/W2971690404","https://openalex.org/W2984336612","https://openalex.org/W2999580270","https://openalex.org/W3007285729","https://openalex.org/W3015313862","https://openalex.org/W3027325047","https://openalex.org/W3032123378","https://openalex.org/W3041085747","https://openalex.org/W3042130878","https://openalex.org/W3042910002","https://openalex.org/W3048827317","https://openalex.org/W3080137602","https://openalex.org/W3081615418","https://openalex.org/W3091664817","https://openalex.org/W3097405028","https://openalex.org/W3098229320","https://openalex.org/W3098465726","https://openalex.org/W3101489770","https://openalex.org/W3126584975","https://openalex.org/W3127297964","https://openalex.org/W3131869701","https://openalex.org/W3135156311","https://openalex.org/W3136366652","https://openalex.org/W3136918052","https://openalex.org/W3137064251","https://openalex.org/W3145130117","https://openalex.org/W3145990216","https://openalex.org/W3152894513","https://openalex.org/W3154086429","https://openalex.org/W3155501465","https://openalex.org/W3159295432","https://openalex.org/W3161702043","https://openalex.org/W3174828871","https://openalex.org/W3177828909","https://openalex.org/W3178671025","https://openalex.org/W3188372451","https://openalex.org/W3193069429","https://openalex.org/W3199607358","https://openalex.org/W3207365242","https://openalex.org/W3213237876","https://openalex.org/W3215049942","https://openalex.org/W3216979156","https://openalex.org/W4200115265","https://openalex.org/W4206050343","https://openalex.org/W4206950245","https://openalex.org/W4211041253","https://openalex.org/W4220655797","https://openalex.org/W4223644783","https://openalex.org/W4232549504","https://openalex.org/W4249920046","https://openalex.org/W4251506437","https://openalex.org/W4296032638","https://openalex.org/W4296164039","https://openalex.org/W4300861364","https://openalex.org/W4308834846","https://openalex.org/W4317869953","https://openalex.org/W4318755135","https://openalex.org/W4322718303","https://openalex.org/W4324344300","https://openalex.org/W4327550249","https://openalex.org/W4385766067","https://openalex.org/W4390629483","https://openalex.org/W4392091326","https://openalex.org/W4392518427","https://openalex.org/W4393055258","https://openalex.org/W4393971152","https://openalex.org/W4399258661","https://openalex.org/W4400269626","https://openalex.org/W4402841143","https://openalex.org/W4404458588","https://openalex.org/W4404470875","https://openalex.org/W6657174890","https://openalex.org/W6678815747","https://openalex.org/W6683771740","https://openalex.org/W6715501732","https://openalex.org/W6755882581","https://openalex.org/W6783267081","https://openalex.org/W6783713337","https://openalex.org/W6787264416","https://openalex.org/W6874031814"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2380075625","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W3204019825"],"abstract_inverted_index":{"Deep":[0],"learning":[1,112],"tools,":[2],"especially":[3],"deep":[4],"generative":[5],"models":[6],"(DGMs),":[7],"provide":[8],"opportunities":[9],"to":[10,24,89,101,125],"accelerate":[11],"and":[12,32,64,78,91],"simplify":[13],"the":[14,38,58,75,84,109,113],"design":[15,90],"of":[16,41,61,80,86,111,117],"drugs.":[17],"As":[18],"drug":[19],"candidates,":[20],"peptides":[21,93],"are":[22,55,70,94],"superior":[23],"other":[25],"biomolecules":[26],"because":[27],"they":[28],"combine":[29],"potency,":[30],"selectivity,":[31],"low":[33],"toxicity.":[34],"This":[35],"review":[36],"examines":[37],"fundamental":[39],"aspects":[40],"current":[42,59],"DGMs":[43],"for":[44],"designing":[45],"therapeutic":[46],"peptide":[47],"sequences.":[48],"First,":[49],"relevant":[50],"databases":[51],"in":[52],"this":[53],"field":[54],"introduced.":[56],"Next,":[57],"situation":[60],"data":[62],"representation":[63],"where":[65],"it":[66],"can":[67,107],"be":[68],"optimized":[69],"discussed.":[71],"Then,":[72],"after":[73],"introducing":[74],"basic":[76],"principles":[77],"variants":[79],"diverse":[81],"DGM":[82],"algorithms,":[83],"applications":[85],"these":[87,127],"methods":[88],"optimize":[92],"stated.":[95],"Finally,":[96],"we":[97],"present":[98],"several":[99],"challenges":[100],"devising":[102],"a":[103],"powerful":[104],"model":[105],"that":[106],"meet":[108],"requirements":[110],"different":[114],"biological":[115],"properties":[116],"peptides,":[118],"as":[119,121],"well":[120],"future":[122],"research":[123],"directions":[124],"address":[126],"challenges.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":23}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
