{"id":"https://openalex.org/W4413213429","doi":"https://doi.org/10.1145/3712255.3726597","title":"Balancing Metabolic Homeostasis and Enzyme Cost with Multi-Objective Evolutionary Algorithms","display_name":"Balancing Metabolic Homeostasis and Enzyme Cost with Multi-Objective Evolutionary Algorithms","publication_year":2025,"publication_date":"2025-07-14","ids":{"openalex":"https://openalex.org/W4413213429","doi":"https://doi.org/10.1145/3712255.3726597"},"language":"en","primary_location":{"id":"doi:10.1145/3712255.3726597","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3712255.3726597","pdf_url":null,"source":{"id":"https://openalex.org/S4363608771","display_name":"Proceedings of the Genetic and Evolutionary Computation Conference Companion","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Genetic and Evolutionary Computation Conference Companion","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117245194","display_name":"Arthur Lequertier","orcid":null},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I3017594750","display_name":"Microbiologie de l\u2019alimentation au service de la sant\u00e9","ror":"https://ror.org/0471cyx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I277688954","https://openalex.org/I3017594750","https://openalex.org/I4210088668","https://openalex.org/I4210099460"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210099460","display_name":"Centre \u00cele-de-France - Jouy-en-Josas - Antony","ror":"https://ror.org/00gtg0p11","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210099460"]},{"id":"https://openalex.org/I4210114484","display_name":"Virologie et Immunologie Mol\u00e9culaires","ror":"https://ror.org/01jvz7e61","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210114484"]},{"id":"https://openalex.org/I4210116501","display_name":"D\u00e9partement G\u00e9n\u00e9tique Animale","ror":"https://ror.org/029xmsm82","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210116501"]},{"id":"https://openalex.org/I4210159481","display_name":"Math\u00e9matiques et Informatique Appliqu\u00e9es du G\u00e9nome \u00e0 l'Environnement","ror":"https://ror.org/05qdnns64","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210159481"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arthur Lequertier","raw_affiliation_strings":["INRAE, Jouy-en-Jousas, France","Universit\u00e9 Paris-Saclay, Jouy-en-Jousas, France"],"raw_orcid":"https://orcid.org/0009-0002-4981-6804","affiliations":[{"raw_affiliation_string":"INRAE, Jouy-en-Jousas, France","institution_ids":["https://openalex.org/I4210099460","https://openalex.org/I4210114484","https://openalex.org/I4210116501","https://openalex.org/I4210159481","https://openalex.org/I4210088668"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Jouy-en-Jousas, France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I3017594750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038913522","display_name":"Alberto Tonda","orcid":"https://orcid.org/0000-0001-5895-4809"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alberto Tonda","raw_affiliation_strings":["INRAE, Palaiseau, France","Universit\u00e9 Paris-Saclay, Palaiseau, France"],"raw_orcid":"https://orcid.org/0000-0001-5895-4809","affiliations":[{"raw_affiliation_string":"INRAE, Palaiseau, France","institution_ids":["https://openalex.org/I4210088668"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Palaiseau, France","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046914403","display_name":"Wolfram Liebermeister","orcid":"https://orcid.org/0000-0002-2568-2381"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I3017594750","display_name":"Microbiologie de l\u2019alimentation au service de la sant\u00e9","ror":"https://ror.org/0471cyx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I277688954","https://openalex.org/I3017594750","https://openalex.org/I4210088668","https://openalex.org/I4210099460"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210099460","display_name":"Centre \u00cele-de-France - Jouy-en-Josas - Antony","ror":"https://ror.org/00gtg0p11","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210099460"]},{"id":"https://openalex.org/I4210114484","display_name":"Virologie et Immunologie Mol\u00e9culaires","ror":"https://ror.org/01jvz7e61","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210114484"]},{"id":"https://openalex.org/I4210116501","display_name":"D\u00e9partement G\u00e9n\u00e9tique Animale","ror":"https://ror.org/029xmsm82","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210116501"]},{"id":"https://openalex.org/I4210159481","display_name":"Math\u00e9matiques et Informatique Appliqu\u00e9es du G\u00e9nome \u00e0 l'Environnement","ror":"https://ror.org/05qdnns64","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210159481"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Wolfram Liebermeister","raw_affiliation_strings":["INRAE, Jouy-en-Jousas, France","Universit\u00e9 Paris-Saclay, Jouy-en-Jousas, France"],"raw_orcid":"https://orcid.org/0000-0002-2568-2381","affiliations":[{"raw_affiliation_string":"INRAE, Jouy-en-Jousas, France","institution_ids":["https://openalex.org/I4210099460","https://openalex.org/I4210114484","https://openalex.org/I4210116501","https://openalex.org/I4210159481","https://openalex.org/I4210088668"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Jouy-en-Jousas, France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I3017594750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37378641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"855","last_page":"858"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5950759649276733},{"id":"https://openalex.org/keywords/evolutionary-algorithm","display_name":"Evolutionary algorithm","score":0.5676145553588867},{"id":"https://openalex.org/keywords/evolutionary-computation","display_name":"Evolutionary computation","score":0.45164060592651367},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.16409441828727722}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5950759649276733},{"id":"https://openalex.org/C159149176","wikidata":"https://www.wikidata.org/wiki/Q14489129","display_name":"Evolutionary algorithm","level":2,"score":0.5676145553588867},{"id":"https://openalex.org/C105902424","wikidata":"https://www.wikidata.org/wiki/Q1197129","display_name":"Evolutionary computation","level":2,"score":0.45164060592651367},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.16409441828727722}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1145/3712255.3726597","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3712255.3726597","pdf_url":null,"source":{"id":"https://openalex.org/S4363608771","display_name":"Proceedings of the Genetic and Evolutionary Computation Conference Companion","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Genetic and Evolutionary Computation Conference Companion","raw_type":"proceedings-article"},{"id":"pmh:oai:HAL:hal-05220393v1","is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-05220393","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2025, pp.855-858. &#x27E8;10.1145/3712255.3726597&#x27E9;","raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6800000071525574,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"awards":[{"id":"https://openalex.org/G7309139736","display_name":"Artificial Metabolic Networks","funder_award_id":"ANR-21-CE45-0021","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1595498733","https://openalex.org/W1985161570","https://openalex.org/W2061364094","https://openalex.org/W2094305273","https://openalex.org/W2126105956","https://openalex.org/W2153624566","https://openalex.org/W2155774631","https://openalex.org/W2786627077","https://openalex.org/W4200472936","https://openalex.org/W4280587005","https://openalex.org/W4283804538"],"related_works":["https://openalex.org/W4297582752","https://openalex.org/W4285805405","https://openalex.org/W2391924736","https://openalex.org/W3133779647","https://openalex.org/W1560122427","https://openalex.org/W3041827036","https://openalex.org/W1993493607","https://openalex.org/W2021957875","https://openalex.org/W2802808995","https://openalex.org/W2787833928"],"abstract_inverted_index":{"The":[0],"metabolic":[1,33,67,144],"fluxes":[2],"in":[3,108,143,158],"cells":[4],"are":[5],"regulated":[6],"by":[7,23,82],"metabolites":[8],"that":[9],"bind":[10],"to":[11,146],"enzymes":[12],"and":[13,48,72,102],"modulate":[14],"their":[15,20,29,148],"activities.":[16],"Metabolites":[17],"can":[18,129],"stabilize":[19],"own":[21],"concentrations":[22],"exerting":[24],"a":[25,91],"negative":[26],"feedback":[27],"on":[28],"production":[30],"pathways.":[31],"Although":[32],"networks":[34],"have":[35],"been":[36],"studied":[37],"extensively,":[38],"many":[39],"regulation":[40,64,83],"arrows":[41,89,104],"remain":[42],"unknown.":[43],"To":[44],"model":[45],"the":[46,66,77,86,109],"costs":[47],"benefits":[49],"of":[50,88,96],"direct":[51],"enzyme":[52,79,156],"regulation,":[53],"we":[54,98,122],"apply":[55],"multi-objective":[56,114],"optimization":[57],"with":[58,133,150],"one":[59],"loss":[60,74],"function":[61,75],"describing":[62],"how":[63,100],"stabilizes":[65],"state":[68],"against":[69],"random":[70],"perturbations":[71],"another":[73],"scoring":[76],"extra":[78],"amounts":[80],"required":[81],"arrows.":[84],"Using":[85,111],"number":[87],"as":[90,153],"third":[92],"objective":[93],"for":[94],"ease":[95],"interpretation,":[97],"study":[99,147],"activating":[101],"inhibiting":[103],"should":[105],"be":[106,131],"arranged":[107],"system.":[110],"an":[112,117],"evolutionary":[113],"approach,":[115],"simulating":[116],"evolution":[118],"under":[119],"biological":[120,135],"trade-offs,":[121],"explore":[123],"optimal":[124,138],"arrow":[125],"configurations.":[126],"Our":[127],"framework":[128],"also":[130],"used":[132],"other":[134],"objectives,":[136],"including":[137],"adaptation":[139],"or":[140,155],"information":[141],"transmission":[142],"networks,":[145],"trade-offs":[149],"objectives":[151],"such":[152],"energy":[154],"investment":[157],"cells.":[159]},"counts_by_year":[],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
