{"id":"https://openalex.org/W4407195824","doi":"https://doi.org/10.1145/3707127.3707171","title":"Effects of general anesthetics on the activity of SST+ interneurons in hippocampal CA1 region of mice","display_name":"Effects of general anesthetics on the activity of SST+ interneurons in hippocampal CA1 region of mice","publication_year":2024,"publication_date":"2024-11-08","ids":{"openalex":"https://openalex.org/W4407195824","doi":"https://doi.org/10.1145/3707127.3707171"},"language":"en","primary_location":{"id":"doi:10.1145/3707127.3707171","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3707127.3707171","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 11th International Conference on Biomedical and Bioinformatics Engineering","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104209344","display_name":"Meiling Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Meiling Zhao","raw_affiliation_strings":["Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China","Medical School, Tianjin University, Tianjin, China,"],"affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China","institution_ids":[]},{"raw_affiliation_string":"Medical School, Tianjin University, Tianjin, China,","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110379384","display_name":"Shufan Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shufan Sun","raw_affiliation_strings":["Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China","Medical School, Tianjin University, Tianjin, China,"],"affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China","institution_ids":[]},{"raw_affiliation_string":"Medical School, Tianjin University, Tianjin, China,","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081587154","display_name":"Ling Wang","orcid":"https://orcid.org/0000-0002-2532-6467"},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]},{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Wang","raw_affiliation_strings":["Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China","Medical School, Tianjin University, Tianjin, China,"],"affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China","institution_ids":[]},{"raw_affiliation_string":"Medical School, Tianjin University, Tianjin, China,","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115597650","display_name":"Jing Ren","orcid":"https://orcid.org/0009-0007-9041-9479"},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]},{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Ren","raw_affiliation_strings":["Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China","Medical School, Tianjin University, Tianjin, China,"],"affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China","institution_ids":[]},{"raw_affiliation_string":"Medical School, Tianjin University, Tianjin, China,","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094187937","display_name":"Weiyi Mo","orcid":null},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiyi Mo","raw_affiliation_strings":["Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China","Medical School, Tianjin University, Tianjin, China,"],"affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China","institution_ids":[]},{"raw_affiliation_string":"Medical School, Tianjin University, Tianjin, China,","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068826437","display_name":"Jiajia Yang","orcid":"https://orcid.org/0000-0001-5439-7136"},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]},{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Yang","raw_affiliation_strings":["Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China","Medical School, Tianjin University, Tianjin, China,"],"affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China","institution_ids":[]},{"raw_affiliation_string":"Medical School, Tianjin University, Tianjin, China,","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5104209344"],"corresponding_institution_ids":["https://openalex.org/I162868743","https://openalex.org/I5740404"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26650422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"270","last_page":"275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.8484607934951782},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5387284755706787},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.4923936128616333},{"id":"https://openalex.org/keywords/general-anesthetics","display_name":"General anesthetics","score":0.476098895072937},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3469564914703369},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2435740828514099},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.15999987721443176},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15136072039604187},{"id":"https://openalex.org/keywords/anesthetic","display_name":"Anesthetic","score":0.11325603723526001}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.8484607934951782},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5387284755706787},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4923936128616333},{"id":"https://openalex.org/C2910438640","wikidata":"https://www.wikidata.org/wiki/Q2755101","display_name":"General anesthetics","level":3,"score":0.476098895072937},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3469564914703369},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2435740828514099},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.15999987721443176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15136072039604187},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.11325603723526001}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3707127.3707171","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3707127.3707171","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 11th International Conference on Biomedical and Bioinformatics Engineering","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.4099999964237213,"display_name":"Zero hunger"}],"awards":[{"id":"https://openalex.org/G6281695997","display_name":null,"funder_award_id":"82371886-82202797","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1886379924","https://openalex.org/W2038382211","https://openalex.org/W2042662796","https://openalex.org/W2045221743","https://openalex.org/W2046999866","https://openalex.org/W2059923501","https://openalex.org/W2120064385","https://openalex.org/W2333812832","https://openalex.org/W2462941890","https://openalex.org/W2534783282","https://openalex.org/W2534818475","https://openalex.org/W2552176628","https://openalex.org/W2747612270","https://openalex.org/W2766936425","https://openalex.org/W2792190464","https://openalex.org/W2805094637","https://openalex.org/W2897453771","https://openalex.org/W2947596811","https://openalex.org/W3126390049","https://openalex.org/W3152150661","https://openalex.org/W3153530613","https://openalex.org/W4210502129","https://openalex.org/W4224281833","https://openalex.org/W4284666655"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W2090370544","https://openalex.org/W2391750868","https://openalex.org/W17166845","https://openalex.org/W4385683675"],"abstract_inverted_index":{"Although":[0],"different":[1,64,73,130,156],"general":[2],"anesthetics":[3,65,117,172],"induce":[4],"similar":[5,141],"physiological":[6],"states,":[7],"their":[8],"effects":[9,87,168],"on":[10,48,96,173],"neuronal":[11,152],"activity":[12,54,99,124,131],"are":[13,41,166],"quite":[14],"different,":[15],"which":[16],"is":[17],"closely":[18],"related":[19],"to":[20,63,111,142,184],"brain":[21],"function":[22,32],"such":[23],"as":[24],"memory":[25,34],"and":[26,35,76,93,128,154,177,187,195],"cognition.":[27],"Hippocampus":[28],"serves":[29],"a":[30],"critical":[31],"in":[33,61,79,103,125,151,192],"cognition,":[36],"where":[37],"somatostatin-expressing":[38],"(SST+)":[39],"interneurons":[40,102,127],"the":[42,53,86,97,112,120,143,170,185],"main":[43],"source":[44],"of":[45,55,58,88,100,107,122,169,189],"inhibitory":[46],"synapses":[47],"excitatory":[49],"neurons.":[50],"However,":[51],"how":[52],"this":[56],"subpopulation":[57],"neurons":[59],"changes":[60],"response":[62],"has":[66],"not":[67],"been":[68],"clearly":[69],"explored.":[70],"Through":[71],"switching":[72],"anesthetic":[74],"strategies":[75,191],"using":[77],"chronic":[78],"vivo":[80],"two-photon":[81],"imaging":[82],"recordings,":[83],"we":[84],"monitored":[85],"isoflurane":[89],"(Iso),":[90],"medetomidine/midazolam/fentanyl":[91],"(MMF),":[92],"ketamine/xylazine":[94],"(Keta/Xyl)":[95],"calcium":[98,123,175],"SST+":[101,126],"hippocampal":[104,174],"CA1":[105],"region":[106],"adult":[108],"mice.":[109],"Compared":[110],"awake":[113,144],"state,":[114,145],"all":[115],"three":[116,171],"greatly":[118],"reduced":[119],"amplitude":[121],"induced":[129],"patterns.":[132],"The":[133],"correlation":[134],"during":[135],"anesthesia":[136,190],"with":[137],"Iso":[138],"was":[139],"most":[140],"whereas":[146],"MMF":[147],"or":[148],"Keta/Xyl":[149],"resulted":[150],"de-correlation":[153],"had":[155],"recovery":[157],"efficiencies.":[158],"In":[159],"conclusion,":[160],"our":[161],"results":[162],"suggest":[163],"that":[164],"there":[165],"unique":[167],"dynamics":[176],"correlated":[178],"activity.":[179],"Our":[180],"findings":[181],"may":[182],"contribute":[183],"evaluation":[186],"development":[188],"biological":[193],"research":[194],"clinical":[196],"areas.":[197]},"counts_by_year":[],"updated_date":"2025-12-22T23:10:17.713674","created_date":"2025-10-10T00:00:00"}
