{"id":"https://openalex.org/W4406328436","doi":"https://doi.org/10.1145/3706890.3707028","title":"Network pharmacological analysis of Baishao Shujin Pills for the treatment of arthritis and determination of paeoniflorin","display_name":"Network pharmacological analysis of Baishao Shujin Pills for the treatment of arthritis and determination of paeoniflorin","publication_year":2024,"publication_date":"2024-08-13","ids":{"openalex":"https://openalex.org/W4406328436","doi":"https://doi.org/10.1145/3706890.3707028"},"language":"en","primary_location":{"id":"doi:10.1145/3706890.3707028","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3706890.3707028","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 5th International Symposium on Artificial Intelligence for Medicine Science","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100892760","display_name":"Jie He","orcid":"https://orcid.org/0009-0003-4601-976X"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie He","raw_affiliation_strings":["School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"raw_orcid":"https://orcid.org/0009-0003-4601-976X","affiliations":[{"raw_affiliation_string":"School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xueying Zhang","orcid":"https://orcid.org/0009-0007-9406-1531"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueying Zhang","raw_affiliation_strings":["School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"raw_orcid":"https://orcid.org/0009-0007-9406-1531","affiliations":[{"raw_affiliation_string":"School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028693758","display_name":"Yuxi Jia","orcid":"https://orcid.org/0009-0007-9904-6795"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxi Jia","raw_affiliation_strings":["School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"raw_orcid":"https://orcid.org/0009-0007-9904-6795","affiliations":[{"raw_affiliation_string":"School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059055943","display_name":"Qilong Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qilong Zhou","raw_affiliation_strings":["School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"raw_orcid":"https://orcid.org/0009-0008-2216-9719","affiliations":[{"raw_affiliation_string":"School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083223950","display_name":"Yunjing Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunjing Wang","raw_affiliation_strings":["School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"raw_orcid":"https://orcid.org/0009-0006-0587-0373","affiliations":[{"raw_affiliation_string":"School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027317305","display_name":"Yujie Ye","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujie Ye","raw_affiliation_strings":["School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"raw_orcid":"https://orcid.org/0009-0004-8415-0758","affiliations":[{"raw_affiliation_string":"School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I43922553"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"808","last_page":"812"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.9905999898910522,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.989799976348877,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paeoniflorin","display_name":"Paeoniflorin","score":0.9337844252586365},{"id":"https://openalex.org/keywords/pill","display_name":"Pill","score":0.6349881887435913},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.44463425874710083},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43078354001045227},{"id":"https://openalex.org/keywords/arthritis","display_name":"Arthritis","score":0.4230974316596985},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"Traditional medicine","score":0.37109655141830444},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.23988869786262512},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.15374013781547546},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.11294606328010559},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.10892540216445923}],"concepts":[{"id":"https://openalex.org/C2776918747","wikidata":"https://www.wikidata.org/wiki/Q7124104","display_name":"Paeoniflorin","level":3,"score":0.9337844252586365},{"id":"https://openalex.org/C81603835","wikidata":"https://www.wikidata.org/wiki/Q3457430","display_name":"Pill","level":2,"score":0.6349881887435913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44463425874710083},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43078354001045227},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4230974316596985},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.37109655141830444},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23988869786262512},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15374013781547546},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11294606328010559},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.10892540216445923},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3706890.3707028","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3706890.3707028","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 5th International Symposium on Artificial Intelligence for Medicine Science","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.7599999904632568}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W2026123588","https://openalex.org/W2052853106","https://openalex.org/W2779890865","https://openalex.org/W2940901016","https://openalex.org/W3010418487","https://openalex.org/W3186574808","https://openalex.org/W3215837414","https://openalex.org/W4214874864","https://openalex.org/W4234997974","https://openalex.org/W4244006029","https://openalex.org/W4244648861","https://openalex.org/W4289257222","https://openalex.org/W4319812545","https://openalex.org/W4376641064","https://openalex.org/W4386168264","https://openalex.org/W4387580023","https://openalex.org/W6679857238","https://openalex.org/W6702013163","https://openalex.org/W6712356647","https://openalex.org/W6746986690","https://openalex.org/W6791699557"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2372312188","https://openalex.org/W2381930998","https://openalex.org/W2370265641","https://openalex.org/W2389506936","https://openalex.org/W2373787254","https://openalex.org/W2398029803","https://openalex.org/W2942125683","https://openalex.org/W1522083451"],"abstract_inverted_index":{"Objective":[0],"To":[1],"analyze":[2],"the":[3,10,22,38,44,50,124,130,161,174],"mechanism":[4],"of":[5,12,24,30,67,126,133,142,163,177],"Baishao":[6,70,143,178],"Shujin":[7,71,144,179],"Pills":[8,72,145],"for":[9,21,40],"treatment":[11],"arthritis":[13,147],"by":[14,75],"network":[15],"pharmacology":[16],"and":[17,35,42,59,93,111,129,160],"establish":[18],"a":[19],"method":[20,66,171],"determination":[23,64],"paeoniflorin":[25,68,134],"content.":[26],"Methods":[27],"The":[28,63,120,139,168],"targets":[29,39,46,162],"active":[31,81],"ingredients":[32,82],"were":[33,47,83,104],"predicted":[34],"intersected":[36,45],"with":[37],"arthritis,":[41],"then":[43],"imported":[48],"into":[49],"database":[51],"to":[52,86],"obtain":[53],"PPI":[54],"networks,":[55],"GO":[56,97],"analysis":[57,98,116],"results,":[58],"KEGG":[60,114],"enrichment":[61,115],"results.":[62],"analytical":[65],"in":[69],"was":[73,135],"established":[74,169],"high-performance":[76],"liquid":[77],"chromatography.":[78],"Results":[79],"106":[80],"screened,":[84],"corresponding":[85],"894":[87],"drug":[88],"targets,":[89,92],"603":[90],"disease":[91],"126":[94],"intersecting":[95],"targets.":[96],"results":[99],"showed":[100],"that":[101],"246":[102],"entries":[103],"obtained,":[105],"including":[106],"230":[107],"BPs,":[108],"5":[109],"CCs,":[110],"11":[112],"MFs.":[113],"screened":[117],"59":[118],"pathways.":[119],"methodological":[121],"investigation":[122],"met":[123],"requirements":[125],"quantitative":[127],"analysis,":[128],"average":[131],"content":[132,176],"2.243":[136],"mg/g.":[137],"Conclusion":[138],"therapeutic":[140],"effect":[141],"on":[146],"is":[148],"mainly":[149],"exerted":[150],"through":[151],"Kaposi":[152],"sarcoma-associated":[153],"herpesvirus":[154],"infection,":[155],"Coronavirus":[156],"disease-":[157],"COVID-19":[158],"pathways,":[159],"TNF,":[164],"AKT1,":[165],"CXCL8,":[166],"etc.":[167],"HPLC":[170],"can":[172],"determine":[173],"main":[175],"Pills.":[180]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}