{"id":"https://openalex.org/W4406328931","doi":"https://doi.org/10.1145/3706890.3707022","title":"Platycodonis Radix and Aurantii Fructus drug pair in the treatment of reflux esophagitis, a network pharmacologic analysis","display_name":"Platycodonis Radix and Aurantii Fructus drug pair in the treatment of reflux esophagitis, a network pharmacologic analysis","publication_year":2024,"publication_date":"2024-08-13","ids":{"openalex":"https://openalex.org/W4406328931","doi":"https://doi.org/10.1145/3706890.3707022"},"language":"en","primary_location":{"id":"doi:10.1145/3706890.3707022","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3706890.3707022","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 5th International Symposium on Artificial Intelligence for Medicine Science","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068212131","display_name":"Ziqing Gao","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ziqing Gao","raw_affiliation_strings":["School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028522216","display_name":"Yajun Chen","orcid":"https://orcid.org/0009-0003-5005-2917"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yajun Chen","raw_affiliation_strings":["School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083223950","display_name":"Yunjing Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunjing Wang","raw_affiliation_strings":["School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100445966","display_name":"Xueying Zhang","orcid":"https://orcid.org/0009-0008-5804-4512"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueying Zhang","raw_affiliation_strings":["School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109768156","display_name":"Tao Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Huang","raw_affiliation_strings":["School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5068212131"],"corresponding_institution_ids":["https://openalex.org/I43922553"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44284099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"770","last_page":"775"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12846","display_name":"Ginkgo biloba and Cashew Applications","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12846","display_name":"Ginkgo biloba and Cashew Applications","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9846000075340271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radix","display_name":"Radix (gastropod)","score":0.7720464468002319},{"id":"https://openalex.org/keywords/reflux-esophagitis","display_name":"Reflux esophagitis","score":0.7436020374298096},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5669742822647095},{"id":"https://openalex.org/keywords/reflux","display_name":"Reflux","score":0.5588511228561401},{"id":"https://openalex.org/keywords/esophagitis","display_name":"Esophagitis","score":0.47710472345352173},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.42246997356414795},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3465383052825928},{"id":"https://openalex.org/keywords/gastroenterology","display_name":"Gastroenterology","score":0.3373194932937622},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2847078740596771},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.08403250575065613},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.083780437707901}],"concepts":[{"id":"https://openalex.org/C2779091547","wikidata":"https://www.wikidata.org/wiki/Q287565","display_name":"Radix (gastropod)","level":2,"score":0.7720464468002319},{"id":"https://openalex.org/C2909576783","wikidata":"https://www.wikidata.org/wiki/Q298230","display_name":"Reflux esophagitis","level":4,"score":0.7436020374298096},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5669742822647095},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.5588511228561401},{"id":"https://openalex.org/C2779920096","wikidata":"https://www.wikidata.org/wiki/Q298230","display_name":"Esophagitis","level":4,"score":0.47710472345352173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42246997356414795},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3465383052825928},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3373194932937622},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2847078740596771},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08403250575065613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.083780437707901},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3706890.3707022","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3706890.3707022","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 5th International Symposium on Artificial Intelligence for Medicine Science","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.699999988079071}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W248336665","https://openalex.org/W2361876452","https://openalex.org/W4249426929","https://openalex.org/W4395052243","https://openalex.org/W4399296411"],"related_works":["https://openalex.org/W2353838635","https://openalex.org/W2012249755","https://openalex.org/W2036867926","https://openalex.org/W1976377569","https://openalex.org/W1966575535","https://openalex.org/W54993233","https://openalex.org/W1981884830","https://openalex.org/W3145625790","https://openalex.org/W2332129842","https://openalex.org/W2009121761"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"explore":[2],"Platycodonis":[3,25,39,87],"Radix":[4,26,40,88],"and":[5,22,27,35,45,65,81,89,101,103,111],"Aurantii":[6,28,46,90],"Fructus":[7,29,47,91],"for":[8],"the":[9,57,69],"treatment":[10],"of":[11,24,59,77],"reflux":[12,119],"esophagitis":[13],"by":[14,32],"network":[15,36,53],"pharmacologic.":[16],"Methods:":[17],"The":[18],"active":[19,43,50],"components,":[20,44],"targets":[21],"pathways":[23,106],"are":[30,67],"analyzed":[31],"literature":[33],"summation":[34],"pharmacology.":[37],"Results:":[38],"has":[41,48],"7":[42],"5":[49],"components.":[51],"PPI":[52],"diagram":[54],"shows":[55],"that":[56],"genes":[58],"GAPDH,":[60],"AKT1,":[61],"ESR1,":[62],"TNF,":[63],"EGFR,":[64],"TP53":[66],"in":[68,95],"core":[70],"position.":[71],"GO":[72],"analysis":[73],"obtained":[74],"a":[75],"total":[76],"953":[78],"biological":[79,96],"entries":[80],"161":[82],"KEGG":[83],"pathway-enriched":[84],"entries.":[85],"Conclusion:":[86],"may":[92],"be":[93],"involved":[94],"processes":[97],"such":[98,107],"as":[99,108],"phosphorylation":[100],"apoptosis,":[102],"regulate":[104],"signaling":[105],"cancer":[109],"pathway":[110],"PI3K-Akt":[112],"pathway,":[113],"thus":[114],"exerting":[115],"therapeutic":[116],"effects":[117],"on":[118],"esophagitis.":[120]},"counts_by_year":[],"updated_date":"2025-12-23T23:11:35.936235","created_date":"2025-10-10T00:00:00"}
