{"id":"https://openalex.org/W4406363761","doi":"https://doi.org/10.1145/3700666.3700696","title":"Regulation of Telomerase in Normal and Cancer Stem Cells","display_name":"Regulation of Telomerase in Normal and Cancer Stem Cells","publication_year":2024,"publication_date":"2024-09-13","ids":{"openalex":"https://openalex.org/W4406363761","doi":"https://doi.org/10.1145/3700666.3700696"},"language":"en","primary_location":{"id":"doi:10.1145/3700666.3700696","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3700666.3700696","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 11th International Conference on Bioinformatics Research and Applications","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034780523","display_name":"Ik-On Chan","orcid":null},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"I Lam Chan","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0009-0007-6448-3901","affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034780523"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":0.3097,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.65198278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"78","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomerase","display_name":"Telomerase","score":0.6429318189620972},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5584734678268433},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.46067580580711365},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.41657736897468567},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34543922543525696},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3247791528701782},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17320117354393005},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09314075112342834}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.6429318189620972},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5584734678268433},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46067580580711365},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41657736897468567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34543922543525696},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3247791528701782},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17320117354393005},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09314075112342834}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3700666.3700696","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3700666.3700696","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 11th International Conference on Bioinformatics Research and Applications","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1532078022","https://openalex.org/W1653629301","https://openalex.org/W1977607105","https://openalex.org/W1980541833","https://openalex.org/W1981358003","https://openalex.org/W1996026958","https://openalex.org/W1998196049","https://openalex.org/W2037650640","https://openalex.org/W2062437408","https://openalex.org/W2065247176","https://openalex.org/W2079934965","https://openalex.org/W2081464023","https://openalex.org/W2092476508","https://openalex.org/W2096176330","https://openalex.org/W2102074847","https://openalex.org/W2105678404","https://openalex.org/W2117692326","https://openalex.org/W2142113620","https://openalex.org/W2170798594","https://openalex.org/W2300198160","https://openalex.org/W2463090465","https://openalex.org/W2523690171","https://openalex.org/W2555075376","https://openalex.org/W2605219687","https://openalex.org/W2763367287","https://openalex.org/W2892224724","https://openalex.org/W2970501957","https://openalex.org/W3005076731","https://openalex.org/W3014612309","https://openalex.org/W3046047916","https://openalex.org/W3047693299","https://openalex.org/W3106117180","https://openalex.org/W3123843327","https://openalex.org/W3162473212","https://openalex.org/W3176954430","https://openalex.org/W3189372222","https://openalex.org/W3204887557","https://openalex.org/W3215153264","https://openalex.org/W4213091566","https://openalex.org/W4224030188","https://openalex.org/W4292199302","https://openalex.org/W4296466447","https://openalex.org/W7131907535"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W38648996","https://openalex.org/W2403399378","https://openalex.org/W2020995651","https://openalex.org/W4241189537","https://openalex.org/W2043713674","https://openalex.org/W1995555192","https://openalex.org/W3150349444","https://openalex.org/W2139793739","https://openalex.org/W2352423112"],"abstract_inverted_index":{"Dysfunction":[0],"of":[1,18,34,96,149,192],"telomerase,":[2,35],"a":[3,146,182],"ribonucleoprotein":[4],"that":[5,106],"repairs":[6],"telomeres,":[7],"can":[8,142],"lead":[9,92],"to":[10,29,93,100,159,178],"cancer.":[11],"Telomerase":[12,140,153],"activity":[13,141],"varies":[14],"between":[15],"different":[16],"types":[17],"cells":[19,27,41,48],"and":[20,52,62,124,133,155,174,196],"is":[21],"abnormally":[22],"high":[23],"in":[24,31,37,57,79,87,110,130,162,169,194],"cancer":[25,39,63,150,163,183,197],"stem":[26,40,47,151,198],"due":[28],"changes":[30],"the":[32,38,73,88,94,97,171,190],"regulation":[33,191],"resulting":[36],"acquiring":[42],"replicative":[43],"immortality":[44],"capacity.":[45],"Cancer":[46],"have":[49],"stemness":[50],"properties":[51],"play":[53],"an":[54,101],"important":[55],"role":[56],"tumour":[58,60,172],"growth,":[59],"recurrence":[61],"metastasis.":[64],"Peer-reviewed":[65],"articles":[66],"from":[67],"publicly":[68],"available":[69],"databases":[70],"published":[71],"over":[72],"past":[74],"twenty":[75],"years":[76],"were":[77],"included":[78],"this":[80],"study.":[81],"During":[82],"early":[83],"tumourigenesis,":[84],"non-coding":[85],"mutations":[86],"TERT":[89,114],"gene":[90],"promotor":[91],"binding":[95,104],"GABPA-GABPB":[98],"tetramer":[99],"extra":[102],"ETS":[103],"site":[105],"does":[107],"not":[108],"exist":[109],"normal":[111,195],"cells,":[112],"increasing":[113],"transcription.":[115],"Various":[116],"factors,":[117],"such":[118,166],"as":[119,145,167,181],"sex":[120],"hormones,":[121],"stress":[122],"hormones":[123],"growth":[125],"factors":[126],"are":[127,157,176],"also":[128],"involved":[129],"telomerase":[131,137,180,193],"regulation,":[132],"their":[134],"effect":[135],"on":[136,189],"activities":[138],"varies.":[139],"be":[143,160],"used":[144,161],"potential":[147],"biomarker":[148],"cells.":[152,199],"inhibitors":[154],"immunotherapies":[156],"developed":[158],"therapy.":[164],"Challenges":[165],"difficulty":[168],"targeting":[170],"exist,":[173],"there":[175],"limitations":[177],"using":[179],"therapeutic":[184],"target.":[185],"This":[186],"paper":[187],"focuses":[188]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
