{"id":"https://openalex.org/W4405427253","doi":"https://doi.org/10.1145/3698587.3701465","title":"Deciphering Bladder Cancer-Related circRNA Biomarkers: An Ensemble Model Integrating Deep Learning and Statistics for circRNA Analysis","display_name":"Deciphering Bladder Cancer-Related circRNA Biomarkers: An Ensemble Model Integrating Deep Learning and Statistics for circRNA Analysis","publication_year":2024,"publication_date":"2024-11-22","ids":{"openalex":"https://openalex.org/W4405427253","doi":"https://doi.org/10.1145/3698587.3701465"},"language":"en","primary_location":{"id":"doi:10.1145/3698587.3701465","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3698587.3701465","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 15th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089637336","display_name":"Yulian Ding","orcid":"https://orcid.org/0000-0001-7435-7094"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yulian Ding","raw_affiliation_strings":["Central for High Performance Computing, Shenzhen Institute of Advanced Technology, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0001-7435-7094","affiliations":[{"raw_affiliation_string":"Central for High Performance Computing, Shenzhen Institute of Advanced Technology, Shenzhen, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101465265","display_name":"Yi Pan","orcid":"https://orcid.org/0000-0002-2766-3096"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Pan","raw_affiliation_strings":["Computer Science and Control Engineering, Shenzhen University of Advanced Technology; Shenzhen Key Laboratory of Intelligent Bioinformatics, Shenzhen Institute of Advanced Technology, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0002-2766-3096","affiliations":[{"raw_affiliation_string":"Computer Science and Control Engineering, Shenzhen University of Advanced Technology; Shenzhen Key Laboratory of Intelligent Bioinformatics, Shenzhen Institute of Advanced Technology, Shenzhen, China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078805938","display_name":"C. Ronald Geyer","orcid":"https://orcid.org/0000-0003-1628-9665"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ronald C. Geyer","raw_affiliation_strings":["Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, Canada"],"raw_orcid":"https://orcid.org/0000-0003-1628-9665","affiliations":[{"raw_affiliation_string":"Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083732133","display_name":"Franco J. Vizeacoumar","orcid":"https://orcid.org/0000-0002-6452-5207"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Franco J. Vizeacoumar","raw_affiliation_strings":["Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, Saskachewan, Canada","Division of Oncology, University of Saskatchewan, Saskatoon, Saskachewan, Canada"],"raw_orcid":"https://orcid.org/0000-0002-6452-5207","affiliations":[{"raw_affiliation_string":"Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, Saskachewan, Canada","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"Division of Oncology, University of Saskatchewan, Saskatoon, Saskachewan, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037627456","display_name":"Frederick S. Vizeacoumar","orcid":"https://orcid.org/0000-0002-4676-2911"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Frederick S. Vizeacoumar","raw_affiliation_strings":["Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, Saskachewan, Canada","Division of Oncology, University of Saskatchewan, Saskatoon, Saskachewan, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4676-2911","affiliations":[{"raw_affiliation_string":"Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, Saskachewan, Canada","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"Division of Oncology, University of Saskatchewan, Saskatoon, Saskachewan, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091157395","display_name":"Fang\u2010Xiang Wu","orcid":"https://orcid.org/0000-0002-4593-9332"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fang-Xiang Wu","raw_affiliation_strings":["Division of Biomedical Engineering, Department of Computer Science, University of Saskatchewan, Saskatoon, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4593-9332","affiliations":[{"raw_affiliation_string":"Division of Biomedical Engineering, Department of Computer Science, University of Saskatchewan, Saskatoon, Canada","institution_ids":["https://openalex.org/I32625721"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5929886102676392},{"id":"https://openalex.org/keywords/ensemble-learning","display_name":"Ensemble learning","score":0.5088067650794983},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.49586185812950134},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3256841003894806}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5929886102676392},{"id":"https://openalex.org/C45942800","wikidata":"https://www.wikidata.org/wiki/Q245652","display_name":"Ensemble learning","level":2,"score":0.5088067650794983},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.49586185812950134},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3256841003894806}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3698587.3701465","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3698587.3701465","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 15th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3172799507","display_name":null,"funder_award_id":"No. U22A2041 and No. 62402489","funder_id":"https://openalex.org/F4320323817","funder_display_name":"Universitas Brawijaya"},{"id":"https://openalex.org/G4523459097","display_name":null,"funder_award_id":"PJT-156263","funder_id":"https://openalex.org/F4320323817","funder_display_name":"Universitas Brawijaya"},{"id":"https://openalex.org/G8295234578","display_name":null,"funder_award_id":"No. 2023M743688","funder_id":"https://openalex.org/F4320323817","funder_display_name":"Universitas Brawijaya"}],"funders":[{"id":"https://openalex.org/F4320323817","display_name":"Universitas Brawijaya","ror":"https://ror.org/01wk3d929"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W2034305079","https://openalex.org/W2035297454","https://openalex.org/W2105935489","https://openalex.org/W2318224129","https://openalex.org/W2602188454","https://openalex.org/W2799912797","https://openalex.org/W2887110217","https://openalex.org/W2942409680","https://openalex.org/W2952235410","https://openalex.org/W2964331590","https://openalex.org/W2973109306","https://openalex.org/W2998081701","https://openalex.org/W3008452716","https://openalex.org/W3012654542","https://openalex.org/W3027920886","https://openalex.org/W3092491183","https://openalex.org/W3102493364","https://openalex.org/W3108775243","https://openalex.org/W3118442307","https://openalex.org/W3157159473","https://openalex.org/W4213138800","https://openalex.org/W4225761113","https://openalex.org/W4282932503","https://openalex.org/W4296099054","https://openalex.org/W4323037575","https://openalex.org/W4360770766","https://openalex.org/W4361007618","https://openalex.org/W4362601452","https://openalex.org/W4367669309","https://openalex.org/W4386026568","https://openalex.org/W4386305887","https://openalex.org/W4386307602","https://openalex.org/W4386947375","https://openalex.org/W4388000718","https://openalex.org/W4391426732","https://openalex.org/W4391744412","https://openalex.org/W4392379040","https://openalex.org/W4392558716"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W4387369504","https://openalex.org/W3046775127","https://openalex.org/W4394896187","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W3107602296","https://openalex.org/W4364306694","https://openalex.org/W4312192474"],"abstract_inverted_index":{"Circular":[0],"RNAs":[1],"(circRNAs),":[2],"a":[3,110],"class":[4],"of":[5,18,61,112,134,148,166,183],"gene":[6],"expression":[7,86],"regulators":[8],"with":[9,140,143],"closed-loop":[10],"structures,":[11],"have":[12,137],"been":[13],"implicated":[14],"in":[15,29,99,170,178],"the":[16,70,75,106,124,146,164],"pathogenesis":[17],"various":[19],"diseases,":[20],"including":[21],"bladder":[22],"cancer":[23],"(BC).":[24],"Their":[25],"stability":[26],"and":[27,36,50,65,81,97,118,181],"presence":[28],"body":[30],"fluids":[31],"suggest":[32],"potential":[33,156],"as":[34],"diagnostic":[35],"prognostic":[37],"biomarkers.":[38,160],"This":[39],"study":[40],"employed":[41,122],"an":[42],"ensemble":[43],"model":[44],"integrating":[45],"deep":[46,119],"learning,":[47],"feature":[48,114,116],"selection,":[49,115],"statistical":[51],"analysis":[52],"to":[53,92,95,105],"identify":[54],"BC-associated":[55],"circRNA":[56,132,159],"biomarkers":[57],"from":[58],"RNA-sequencing":[59],"data":[60],"454":[62],"BC":[63,158,172],"patients":[64],"19":[66],"healthy":[67],"controls.":[68],"Utilizing":[69],"CIRCexplorer3":[71],"tool,":[72],"we":[73],"preprocessed":[74],"RNA-seq":[76],"data,":[77],"identifying":[78],"22,311":[79],"circRNAs":[80,154],"categorizing":[82],"them":[83],"based":[84],"on":[85],"patterns":[87],"into":[88],"three":[89],"classes:":[90],"exclusive":[91,94],"BC,":[93,144],"normals,":[96],"present":[98],"both.":[100],"Statistical":[101],"methods":[102],"were":[103],"applied":[104],"first":[107],"class,":[108],"while":[109],"combination":[111],"statistics,":[113],"extraction,":[117],"learning":[120],"was":[121],"for":[123],"third":[125],"class.":[126],"Our":[127],"approach":[128],"yielded":[129],"32":[130],"novel":[131,157],"biomarkers,":[133],"which":[135],"21":[136],"corresponding":[138],"genes":[139],"verified":[141],"associations":[142],"validating":[145],"effectiveness":[147],"our":[149,167],"method.":[150],"The":[151,161],"remaining":[152],"11":[153],"represent":[155],"results":[162],"underscore":[163],"efficacy":[165],"computational":[168],"strategy":[169],"advancing":[171],"non-invasive":[173],"biomarker":[174],"discovery,":[175],"potentially":[176],"aiding":[177],"early":[179],"diagnosis":[180],"prognosis":[182],"BC.":[184]},"counts_by_year":[],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
