{"id":"https://openalex.org/W4405427496","doi":"https://doi.org/10.1145/3698587.3701347","title":"Detecting and Subtyping Anomalous Single Cells with M2ASDA","display_name":"Detecting and Subtyping Anomalous Single Cells with M2ASDA","publication_year":2024,"publication_date":"2024-11-22","ids":{"openalex":"https://openalex.org/W4405427496","doi":"https://doi.org/10.1145/3698587.3701347"},"language":"en","primary_location":{"id":"doi:10.1145/3698587.3701347","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3698587.3701347","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 15th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"},"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022227779","display_name":"Kaichen Xu","orcid":"https://orcid.org/0009-0001-1768-1303"},"institutions":[{"id":"https://openalex.org/I158934434","display_name":"Zhongnan University of Economics and Law","ror":"https://ror.org/04yqxxq63","country_code":"CN","type":"education","lineage":["https://openalex.org/I158934434"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaichen Xu","raw_affiliation_strings":["Zhongnan University of Economics and Law, Wuhan, China"],"raw_orcid":"https://orcid.org/0009-0001-1768-1303","affiliations":[{"raw_affiliation_string":"Zhongnan University of Economics and Law, Wuhan, China","institution_ids":["https://openalex.org/I158934434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045078429","display_name":"Kainan Liu","orcid":"https://orcid.org/0009-0004-0299-8799"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kainan Liu","raw_affiliation_strings":["The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China"],"raw_orcid":"https://orcid.org/0009-0004-0299-8799","affiliations":[{"raw_affiliation_string":"The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100737553","display_name":"Linjie Wang","orcid":"https://orcid.org/0009-0004-2028-7501"},"institutions":[{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linjie Wang","raw_affiliation_strings":["Northeastern University, Shenyang, China"],"raw_orcid":"https://orcid.org/0009-0004-2028-7501","affiliations":[{"raw_affiliation_string":"Northeastern University, Shenyang, China","institution_ids":["https://openalex.org/I9224756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115458732","display_name":"Yueyang Ding","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yueyang Ding","raw_affiliation_strings":["Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, Hangzhou, China"],"raw_orcid":"https://orcid.org/0009-0002-8373-7843","affiliations":[{"raw_affiliation_string":"Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022128301","display_name":"Yan Lu","orcid":"https://orcid.org/0009-0006-6492-2321"},"institutions":[{"id":"https://openalex.org/I158934434","display_name":"Zhongnan University of Economics and Law","ror":"https://ror.org/04yqxxq63","country_code":"CN","type":"education","lineage":["https://openalex.org/I158934434"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Lu","raw_affiliation_strings":["Zhongnan University of Economics and Law, Wuhan, China"],"raw_orcid":"https://orcid.org/0009-0006-6492-2321","affiliations":[{"raw_affiliation_string":"Zhongnan University of Economics and Law, Wuhan, China","institution_ids":["https://openalex.org/I158934434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083170497","display_name":"Hao Wu","orcid":"https://orcid.org/0000-0003-1269-7354"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Wu","raw_affiliation_strings":["Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0003-1269-7354","affiliations":[{"raw_affiliation_string":"Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065527238","display_name":"Xiaobo Sun","orcid":"https://orcid.org/0000-0001-9876-5666"},"institutions":[{"id":"https://openalex.org/I158934434","display_name":"Zhongnan University of Economics and Law","ror":"https://ror.org/04yqxxq63","country_code":"CN","type":"education","lineage":["https://openalex.org/I158934434"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaobo Sun","raw_affiliation_strings":["Zhongnan University of Economics and Law, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0001-9876-5666","affiliations":[{"raw_affiliation_string":"Zhongnan University of Economics and Law, Wuhan, China","institution_ids":["https://openalex.org/I158934434"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11512","display_name":"Anomaly Detection Techniques and Applications","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11512","display_name":"Anomaly Detection Techniques and Applications","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subtyping","display_name":"Subtyping","score":0.9313902258872986},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6622222065925598},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.31154733896255493}],"concepts":[{"id":"https://openalex.org/C83852419","wikidata":"https://www.wikidata.org/wiki/Q2713292","display_name":"Subtyping","level":2,"score":0.9313902258872986},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6622222065925598},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.31154733896255493}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3698587.3701347","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3698587.3701347","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 15th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2396009657","https://openalex.org/W2799110842","https://openalex.org/W3032826521","https://openalex.org/W2391332606","https://openalex.org/W4229853287","https://openalex.org/W1462775415","https://openalex.org/W2008549446"],"abstract_inverted_index":{"Detecting":[0],"and":[1,8,24,49,53,64,69,81,94,100,111,124,152],"Subtyping":[2],"Anomalous":[3,66],"Single-cells":[4],"(DSAS)":[5],"from":[6],"multi-sample":[7],"multi-modal":[9],"single-cell":[10,22,32,142],"sequencing":[11],"data":[12,112,146],"paves":[13],"the":[14,21,77,89,119,134],"way":[15],"for":[16,30,91],"understanding":[17],"disease":[18],"heterogeneity":[19],"at":[20],"level":[23],"developing":[25],"targeted":[26],"therapies.":[27],"Current":[28],"methods":[29],"anomalous":[31],"(ASC)":[33],"detection":[34,106],"are":[35],"limited":[36],"by":[37],"their":[38],"reliance":[39],"on":[40],"scarce":[41],"\"expert-defined\"":[42],"markers,":[43],"inability":[44],"to":[45,51,128,133],"differentiate":[46],"ASC":[47,78,92,105],"subtypes,":[48],"sensitivity":[50],"cross-sample":[52],"cross-modal":[54],"technical":[55,122],"variations.":[56],"To":[57],"address":[58],"these":[59],"limitations,":[60],"we":[61],"propose":[62],"Multi-modal":[63],"Multi-sample":[65],"Single-cell":[67],"Detection":[68],"Annotation":[70],"(M2ASDA),":[71],"an":[72],"innovative":[73],"framework":[74],"that":[75],"integrates":[76],"detection,":[79],"alignment,":[80],"subtyping.":[82],"As":[83],"a":[84],"generative":[85],"model,":[86],"M2ASDA":[87],"eliminates":[88],"need":[90],"markers":[93],"annotated":[95],"references.":[96],"By":[97],"incorporating":[98],"transfer-learning":[99],"style-transfer":[101],"techniques,":[102],"it":[103],"allows":[104],"across":[107],"both":[108],"multiple":[109,161],"samples":[110],"modalities,":[113,147],"effectively":[114],"tackling":[115],"complications":[116],"rooted":[117],"in":[118,157],"intermingling":[120],"of":[121],"variations":[123,127],"ASC-induced":[125],"biological":[126],"achieve":[129],"superior":[130],"performance":[131],"compared":[132],"state-of-the-art":[135],"methods.":[136],"Our":[137],"comprehensive":[138],"evaluations":[139],"using":[140],"real-world":[141],"datasets,":[143,162],"covering":[144],"various":[145],"platforms,":[148],"species,":[149],"tissue":[150],"types,":[151],"diseases,":[153],"demonstrate":[154],"M2ASDA's":[155],"effectiveness":[156],"detecting":[158],"ASCs,":[159],"aligning":[160],"revealing":[163]},"counts_by_year":[],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
