{"id":"https://openalex.org/W4402632716","doi":"https://doi.org/10.1145/3686812.3686813","title":"Constructing an Immune Gene Risk Model Related to Prognosis of Colorectal Cancer Based on Bioinformatics","display_name":"Constructing an Immune Gene Risk Model Related to Prognosis of Colorectal Cancer Based on Bioinformatics","publication_year":2024,"publication_date":"2024-06-21","ids":{"openalex":"https://openalex.org/W4402632716","doi":"https://doi.org/10.1145/3686812.3686813"},"language":"en","primary_location":{"id":"doi:10.1145/3686812.3686813","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3686812.3686813","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 16th International Conference on Computer Modeling and Simulation","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101732863","display_name":"Meiqin Wang","orcid":"https://orcid.org/0009-0004-2102-2206"},"institutions":[{"id":"https://openalex.org/I4210131997","display_name":"Dalian Neusoft University of Information","ror":"https://ror.org/0304ty515","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210131997"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Meiqin Wang","raw_affiliation_strings":["Dalian Neusoft University of Information, China"],"affiliations":[{"raw_affiliation_string":"Dalian Neusoft University of Information, China","institution_ids":["https://openalex.org/I4210131997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000653069","display_name":"Xiuwen Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210131997","display_name":"Dalian Neusoft University of Information","ror":"https://ror.org/0304ty515","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210131997"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuwen Wu","raw_affiliation_strings":["Dalian Neusoft University of Information, China"],"affiliations":[{"raw_affiliation_string":"Dalian Neusoft University of Information, China","institution_ids":["https://openalex.org/I4210131997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102951575","display_name":"Fengdong Sun","orcid":"https://orcid.org/0009-0006-9975-1825"},"institutions":[{"id":"https://openalex.org/I4210131997","display_name":"Dalian Neusoft University of Information","ror":"https://ror.org/0304ty515","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210131997"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengdong Sun","raw_affiliation_strings":["Dalian Neusoft University of Information, China"],"affiliations":[{"raw_affiliation_string":"Dalian Neusoft University of Information, China","institution_ids":["https://openalex.org/I4210131997"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005447468","display_name":"Ningning Li","orcid":"https://orcid.org/0009-0008-8617-3936"},"institutions":[{"id":"https://openalex.org/I4210131997","display_name":"Dalian Neusoft University of Information","ror":"https://ror.org/0304ty515","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210131997"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ningning Li","raw_affiliation_strings":["Dalian Neusoft University of Information, China"],"affiliations":[{"raw_affiliation_string":"Dalian Neusoft University of Information, China","institution_ids":["https://openalex.org/I4210131997"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101732863"],"corresponding_institution_ids":["https://openalex.org/I4210131997"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24343201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.8813999891281128,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.8813999891281128,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.8525999784469604,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.7056790590286255},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5342053174972534},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46058812737464905},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4363110065460205},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4321570098400116},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.42395615577697754},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4154965281486511},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.346265584230423},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.24786314368247986},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2279568612575531},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.17283278703689575},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1318034529685974}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7056790590286255},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5342053174972534},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46058812737464905},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4363110065460205},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4321570098400116},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42395615577697754},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4154965281486511},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.346265584230423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24786314368247986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2279568612575531},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17283278703689575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1318034529685974}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3686812.3686813","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3686812.3686813","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 16th International Conference on Computer Modeling and Simulation","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6899999976158142,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2374019147","https://openalex.org/W2370262613","https://openalex.org/W4362606997","https://openalex.org/W4361825250","https://openalex.org/W4377092742","https://openalex.org/W2015369371","https://openalex.org/W4229447658","https://openalex.org/W2357948923","https://openalex.org/W4313472242","https://openalex.org/W2332159055"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"explore":[2],"immune":[3,40,62,72,118],"prognostic":[4,75,119],"markers":[5],"for":[6,78,125,131],"colon":[7],"adenocarcinoma":[8],"and":[9,22,45,57,83,87,94,116,123,137],"accurately":[10],"predict":[11],"the":[12,31,35,47,50,100,103,108],"survival":[13],"risk":[14],"of":[15,26,34,49,102,110],"colorectal":[16,27,79,111,126],"cancer.":[17,112],"Method:":[18],"Download":[19],"clinical":[20],"information":[21],"RNA":[23],"seq":[24],"data":[25],"cancer":[28,36,80,127],"patients":[29],"from":[30],"TCGA":[32],"database":[33],"genome":[37],"atlas,":[38],"obtain":[39],"related":[41,63,73],"differentially":[42],"expressed":[43],"genes,":[44],"verify":[46,99],"function":[48],"obtained":[51],"genes":[52,65,120],"through":[53,66],"GO":[54],"enrichment":[55],"analysis":[56],"KEGG":[58],"pathway":[59],"analysis.":[60],"Screening":[61],"hub":[64],"co":[67],"expression":[68],"network":[69],"analysis,":[70],"constructing":[71],"gene":[74],"index":[76],"models":[77],"using":[81],"univariate":[82],"multivariate":[84],"Cox":[85],"regression,":[86],"comparing":[88],"them":[89],"with":[90],"widely":[91],"used":[92],"TIDE":[93],"TIS":[95],"scoring":[96],"methods":[97],"to":[98],"accuracy":[101],"constructed":[104],"model":[105],"in":[106],"predicting":[107],"prognosis":[109,135],"Conclusion:":[113],"The":[114],"developed":[115],"validated":[117],"TPM2,":[121],"GLP2R,":[122],"PTH1R":[124],"can":[128],"provide":[129],"direction":[130],"early":[132],"diagnosis,":[133],"patient":[134],"evaluation,":[136],"new":[138],"therapeutic":[139],"targets":[140],"research.":[141]},"counts_by_year":[],"updated_date":"2025-12-27T23:08:20.325037","created_date":"2025-10-10T00:00:00"}