{"id":"https://openalex.org/W4404978876","doi":"https://doi.org/10.1145/3686592.3686610","title":"Evaluating the Bioequivalence of Treatments Using t-ratios Tests","display_name":"Evaluating the Bioequivalence of Treatments Using t-ratios Tests","publication_year":2024,"publication_date":"2024-06-23","ids":{"openalex":"https://openalex.org/W4404978876","doi":"https://doi.org/10.1145/3686592.3686610"},"language":"en","primary_location":{"id":"doi:10.1145/3686592.3686610","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3686592.3686610","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 7th International Conference on Mathematics and Statistics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repositorio.iscte-iul.pt/bitstream/10071/35156/1/conferenceObject_109161.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081055970","display_name":"M. Filomena Teodoro","orcid":"https://orcid.org/0000-0002-7944-0134"},"institutions":[{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]},{"id":"https://openalex.org/I4403386570","display_name":"Marinha Portuguesa","ror":"https://ror.org/0520mfp02","country_code":"PT","type":"government","lineage":["https://openalex.org/I4210117458","https://openalex.org/I4403386570"]},{"id":"https://openalex.org/I921685582","display_name":"Escola Naval","ror":"https://ror.org/01ev6gy70","country_code":"PT","type":"education","lineage":["https://openalex.org/I921685582"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"M. Filomena Teodoro","raw_affiliation_strings":["CEMAT - Center for Computational and Stochastic Mathematics, Insituto Superior T\u00e9cnico, Lisbon University, 1048-001 Lisboa, Portugal","CINAV, Center of Naval Research, Naval Academy, Military Universitary Institute, Portuguese Navy, 1048-001 Lisboa, Portugal"],"affiliations":[{"raw_affiliation_string":"CEMAT - Center for Computational and Stochastic Mathematics, Insituto Superior T\u00e9cnico, Lisbon University, 1048-001 Lisboa, Portugal","institution_ids":["https://openalex.org/I4387152517"]},{"raw_affiliation_string":"CINAV, Center of Naval Research, Naval Academy, Military Universitary Institute, Portuguese Navy, 1048-001 Lisboa, Portugal","institution_ids":["https://openalex.org/I4403386570","https://openalex.org/I921685582"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003883522","display_name":"Marina Andrade","orcid":"https://orcid.org/0000-0001-5412-7144"},"institutions":[{"id":"https://openalex.org/I110026055","display_name":"Iscte \u2013 Instituto Universit\u00e1rio de Lisboa","ror":"https://ror.org/014837179","country_code":"PT","type":"education","lineage":["https://openalex.org/I110026055"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Marina A. P. Andrade","raw_affiliation_strings":["ISCTE, University Institute of Lisbon, 1649-026, Lisboa, Portugal","ISTAR, University Institute of Lisbon, 1649-026, Lisboa, Portugal"],"affiliations":[{"raw_affiliation_string":"ISCTE, University Institute of Lisbon, 1649-026, Lisboa, Portugal","institution_ids":["https://openalex.org/I110026055"]},{"raw_affiliation_string":"ISTAR, University Institute of Lisbon, 1649-026, Lisboa, Portugal","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072680845","display_name":"Teresa Oliveira","orcid":"https://orcid.org/0000-0003-3283-9946"},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I201025148","display_name":"Universidade Aberta","ror":"https://ror.org/02rv3w387","country_code":"PT","type":"education","lineage":["https://openalex.org/I201025148"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Teresa A. Oliveira","raw_affiliation_strings":["CEAUL, Faculdade de Ci\u00eancias, Lisbon University, 1649-014 Lisboa, Portugal","Departamento de Ci\u00eancias e Tecnologia, Universidade Aberta, 1649-014 Lisboa, Portugal"],"affiliations":[{"raw_affiliation_string":"CEAUL, Faculdade de Ci\u00eancias, Lisbon University, 1649-014 Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Departamento de Ci\u00eancias e Tecnologia, Universidade Aberta, 1649-014 Lisboa, Portugal","institution_ids":["https://openalex.org/I201025148"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081055970"],"corresponding_institution_ids":["https://openalex.org/I4387152517","https://openalex.org/I4403386570","https://openalex.org/I921685582"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22402726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"102","last_page":"106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.9735000133514404,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9538000226020813,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioequivalence","display_name":"Bioequivalence","score":0.9299015402793884},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45800328254699707},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3944230377674103},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.35880643129348755},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3221566677093506},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22221681475639343},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.12725743651390076},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.08041301369667053}],"concepts":[{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.9299015402793884},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45800328254699707},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3944230377674103},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.35880643129348755},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3221566677093506},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22221681475639343},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.12725743651390076},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.08041301369667053}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1145/3686592.3686610","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3686592.3686610","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 7th International Conference on Mathematics and Statistics","raw_type":"proceedings-article"},{"id":"pmh:oai:repositorio.iscte-iul.pt:10071/35156","is_oa":true,"landing_page_url":"http://hdl.handle.net/10071/35156","pdf_url":"https://repositorio.iscte-iul.pt/bitstream/10071/35156/1/conferenceObject_109161.pdf","source":{"id":"https://openalex.org/S4306400114","display_name":"Reposit\u00f3rio Institucional do ISCTE-IUL (ISCTE-IUL)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I110026055","host_organization_name":"Iscte \u2013 Instituto Universit\u00e1rio de Lisboa","host_organization_lineage":["https://openalex.org/I110026055"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference object"}],"best_oa_location":{"id":"pmh:oai:repositorio.iscte-iul.pt:10071/35156","is_oa":true,"landing_page_url":"http://hdl.handle.net/10071/35156","pdf_url":"https://repositorio.iscte-iul.pt/bitstream/10071/35156/1/conferenceObject_109161.pdf","source":{"id":"https://openalex.org/S4306400114","display_name":"Reposit\u00f3rio Institucional do ISCTE-IUL (ISCTE-IUL)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I110026055","host_organization_name":"Iscte \u2013 Instituto Universit\u00e1rio de Lisboa","host_organization_lineage":["https://openalex.org/I110026055"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference object"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.5799999833106995}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404978876.pdf"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1554041676","https://openalex.org/W1973574532","https://openalex.org/W1996843574","https://openalex.org/W2074407985","https://openalex.org/W2118452659","https://openalex.org/W2137230952","https://openalex.org/W2142225982","https://openalex.org/W2411805487","https://openalex.org/W2618314571","https://openalex.org/W3146998855","https://openalex.org/W4210893254","https://openalex.org/W4231942106","https://openalex.org/W4254896685","https://openalex.org/W4281640951","https://openalex.org/W4283066032","https://openalex.org/W4296946217","https://openalex.org/W4386116424","https://openalex.org/W4401148936"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W4391375266","https://openalex.org/W2018887812","https://openalex.org/W2044291706","https://openalex.org/W2145901263","https://openalex.org/W2088148024","https://openalex.org/W2321603838","https://openalex.org/W2059849633","https://openalex.org/W2027745545"],"abstract_inverted_index":{"The":[0,49,107],"main":[1],"objective":[2],"of":[3,9,20,22,30,33,40,51,89,96,100,117,120,139],"the":[4,7,18,28,31,42,46,52,57,61,67,90,94,115,118,121,127,142,155],"work":[5],"is":[6,26],"application":[8,108],"experimental":[10,74],"design":[11],"and":[12,45,83,85,102,130],"some":[13],"simple":[14],"tests":[15,97],"(t-ratios)":[16],"in":[17,114],"evaluation":[19],"bioequivalence":[21],"two":[23,38],"treatments.":[24],"It":[25,76],"performed":[27,78],"assessment":[29],"effectiveness":[32],"different":[34],"treatments":[35],"administered":[36],"to":[37,109,152],"groups":[39],"patients:":[41],"control":[43,53,62],"group":[44,54,63],"test":[47],"group.":[48],"comparison":[50],"that":[55,147,154],"received":[56,66],"reference":[58],"medication":[59],"with":[60],"test,":[64],"which":[65],"drug":[68],"under":[69],"study,":[70],"using":[71,81],"a":[72,110],"crossover":[73],"design.":[75],"was":[77,149],"an":[79],"analysis":[80],"t-ratios":[82],"considering":[84,136],"inter-subject":[86],"variability":[87],"formulation":[88],"probabilistic":[91],"model,":[92],"where":[93,126],"specification":[95],"for":[98],"detection":[99],"carryover":[101,129],"period":[103,131],"effects":[104,128],"were":[105,132,158],"considered.":[106],"practical":[111],"case":[112],"consisted":[113],"validation":[116],"hypothesis":[119],"proposed":[122],"model":[123],"took":[124],"place,":[125],"not":[133,159],"significant":[134],"when":[135],"usual":[137],"levels":[138],"significance.":[140],"About":[141],"treatments,":[143],"we":[144],"could":[145],"conclude":[146],"there":[148],"statistical":[150],"significance":[151],"affirm":[153],"studied":[156],"pharmaceuticals":[157],"bioequivalent.":[160]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
