{"id":"https://openalex.org/W4409282785","doi":"https://doi.org/10.1145/3676536.3676744","title":"RABER: Reliability-Aware Bayesian-Optimization-based Control Layer Escape Routing for Flow-based Microfluidics","display_name":"RABER: Reliability-Aware Bayesian-Optimization-based Control Layer Escape Routing for Flow-based Microfluidics","publication_year":2024,"publication_date":"2024-10-27","ids":{"openalex":"https://openalex.org/W4409282785","doi":"https://doi.org/10.1145/3676536.3676744"},"language":"en","primary_location":{"id":"doi:10.1145/3676536.3676744","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3676536.3676744","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3676536.3676744","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 43rd IEEE/ACM International Conference on Computer-Aided Design","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dl.acm.org/doi/pdf/10.1145/3676536.3676744","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100844339","display_name":"Siyuan Liang","orcid":"https://orcid.org/0000-0001-6819-8293"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Siyuan Liang","raw_affiliation_strings":["The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region of China"],"raw_orcid":"https://orcid.org/0000-0001-6819-8293","affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region of China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027725310","display_name":"Rongliang Fu","orcid":null},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Rongliang Fu","raw_affiliation_strings":["The Chinese University of Hong Kong, Shatin, Hong Kong"],"raw_orcid":"https://orcid.org/0000-0003-3744-2083","affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088491433","display_name":"Mengchu Li","orcid":"https://orcid.org/0000-0001-8239-2674"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mengchu Li","raw_affiliation_strings":["Techical University of Munich, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8239-2674","affiliations":[{"raw_affiliation_string":"Techical University of Munich, Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077609536","display_name":"Tsun\u2010Ming Tseng","orcid":"https://orcid.org/0000-0003-1032-8408"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsun-Ming Tseng","raw_affiliation_strings":["Techical University of Munich, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1032-8408","affiliations":[{"raw_affiliation_string":"Techical University of Munich, Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017567485","display_name":"Ulf Schlichtmann","orcid":"https://orcid.org/0000-0003-4431-7619"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulf Schlichtmann","raw_affiliation_strings":["Techical University of Munich, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4431-7619","affiliations":[{"raw_affiliation_string":"Techical University of Munich, Munich, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062800747","display_name":"Tsung-Yi Ho","orcid":"https://orcid.org/0000-0001-7348-5625"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Tsung-Yi Ho","raw_affiliation_strings":["The Chinese University of Hong Kong, Shatin, Hong Kong"],"raw_orcid":"https://orcid.org/0000-0001-7348-5625","affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0515,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.81886514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.6975797414779663},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.662447452545166},{"id":"https://openalex.org/keywords/flow-control","display_name":"Flow control (data)","score":0.6588008999824524},{"id":"https://openalex.org/keywords/reliability","display_name":"Reliability (semiconductor)","score":0.6545782089233398},{"id":"https://openalex.org/keywords/routing","display_name":"Routing (electronic design automation)","score":0.626217246055603},{"id":"https://openalex.org/keywords/layer","display_name":"Layer (electronics)","score":0.43682661652565},{"id":"https://openalex.org/keywords/flow","display_name":"Flow (mathematics)","score":0.41463980078697205},{"id":"https://openalex.org/keywords/bayesian-optimization","display_name":"Bayesian optimization","score":0.4120998680591583},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.23008957505226135},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.21012738347053528},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.12172192335128784},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1024845540523529},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.05954182147979736}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.6975797414779663},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.662447452545166},{"id":"https://openalex.org/C186766456","wikidata":"https://www.wikidata.org/wiki/Q612457","display_name":"Flow control (data)","level":2,"score":0.6588008999824524},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.6545782089233398},{"id":"https://openalex.org/C74172769","wikidata":"https://www.wikidata.org/wiki/Q1446839","display_name":"Routing (electronic design automation)","level":2,"score":0.626217246055603},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.43682661652565},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.41463980078697205},{"id":"https://openalex.org/C2778049539","wikidata":"https://www.wikidata.org/wiki/Q17002908","display_name":"Bayesian optimization","level":2,"score":0.4120998680591583},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.23008957505226135},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.21012738347053528},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.12172192335128784},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1024845540523529},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.05954182147979736},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1145/3676536.3676744","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3676536.3676744","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3676536.3676744","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 43rd IEEE/ACM International Conference on Computer-Aided Design","raw_type":"proceedings-article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1747600","is_oa":true,"landing_page_url":"https://mediatum.ub.tum.de/1747600","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"ConferencePaper"}],"best_oa_location":{"id":"doi:10.1145/3676536.3676744","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3676536.3676744","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3676536.3676744","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 43rd IEEE/ACM International Conference on Computer-Aided Design","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.6200000047683716}],"awards":[{"id":"https://openalex.org/G734667300","display_name":"Layoutentwurf f\u00fcr mikrofluidische Hochintegration mittels Partitionierung und Floorplanning","funder_award_id":"515003344","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7883298418","display_name":"Design und Integration des Testmoduls f\u00fcr die mikrofluidische LargeScale Integration (mLSI)","funder_award_id":"456006534","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320322942","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409282785.pdf","grobid_xml":"https://content.openalex.org/works/W4409282785.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1510052597","https://openalex.org/W2017927472","https://openalex.org/W2070378283","https://openalex.org/W2070855802","https://openalex.org/W2166271465","https://openalex.org/W2378259131","https://openalex.org/W2541240547","https://openalex.org/W2605207075","https://openalex.org/W2761636925","https://openalex.org/W2808740673","https://openalex.org/W2902776818","https://openalex.org/W3102988797","https://openalex.org/W3217423393","https://openalex.org/W4211049957","https://openalex.org/W4239181501","https://openalex.org/W4287322679","https://openalex.org/W4386763911","https://openalex.org/W4389166720","https://openalex.org/W4389166735","https://openalex.org/W4404133520","https://openalex.org/W4404134181","https://openalex.org/W6639090690","https://openalex.org/W6682928080","https://openalex.org/W6685290738","https://openalex.org/W7018071408"],"related_works":["https://openalex.org/W3103016203","https://openalex.org/W2106238498","https://openalex.org/W2463681241","https://openalex.org/W161520385","https://openalex.org/W97203997","https://openalex.org/W2624661525","https://openalex.org/W3106461837","https://openalex.org/W1572874849","https://openalex.org/W2117839501","https://openalex.org/W2139775372"],"abstract_inverted_index":{"After":[0],"decades":[1],"of":[2,10,99,113,132,170],"development,":[3],"flow-based":[4],"microfluidic":[5],"biochips":[6],"have":[7],"become":[8],"one":[9],"the":[11,34,75,89,97,100,106,111,130,136,140,148,153,168,171,176,182,212,221],"most":[12],"promising":[13],"platforms":[14],"for":[15,129,186,199],"biochemical":[16],"experiments.":[17],"Control":[18],"ports,":[19,115],"which":[20,67,93,125,201],"are":[21,26,46],"remarkably":[22],"area-consuming":[23],"punch":[24],"holes,":[25],"interfaces":[27],"to":[28,71,85,119,180,229,244],"external":[29],"pneumatic":[30],"controllers.":[31],"To":[32,142],"prevent":[33],"inserted":[35],"outer":[36],"catheters":[37],"from":[38],"hindering":[39],"microscopic":[40],"observation":[41],"during":[42],"experiments,":[43],"control":[44,62,91,114,149,207,234,238],"ports":[45],"placed":[47],"on":[48],"chip":[49],"boundaries":[50],"in":[51],"practice.":[52],"In":[53],"this":[54],"paper,":[55],"we":[56,155,191],"propose":[57,192],"a":[58,83,157,162,193],"practical":[59],"and":[60,81,152,209,240],"novel":[61],"layer":[63],"escape":[64],"routing":[65,131,184,188],"methodology,":[66],"efficiently":[68,225],"connects":[69],"microvalves":[70,104,134,228],"user-specified":[72,230],"boundaries.":[73],"Particularly,":[74],"proposed":[76,222],"methodology":[77,223],"groups":[78],"certain":[79],"microvalves,":[80,124],"constructs":[82],"tree":[84],"connect":[86,226],"them":[87],"with":[88,161],"same":[90,107],"port,":[92],"is":[94],"regarded":[95],"as":[96,196],"root":[98],"tree.":[101],"Clustering":[102],"more":[103,120],"into":[105],"group":[108],"can":[109,224],"reduce":[110,233],"usage":[112,151],"but":[116],"will":[117],"lead":[118],"intensive":[121],"connections":[122],"among":[123],"becomes":[126],"larger":[127],"obstacles":[128],"other":[133],"outside":[135],"group,":[137],"thereby":[138],"reducing":[139],"routability.":[141],"derive":[143],"an":[144,197],"optimized":[145,183],"tradeoff":[146],"between":[147],"port":[150,235],"routability,":[154],"adapt":[156],"hierarchical":[158],"clustering":[159],"algorithm":[160],"dynamically":[163],"changing":[164],"threshold":[165],"that":[166,220],"ascertains":[167],"closeness":[169],"microvalves.":[172],"We":[173],"also":[174],"adopt":[175],"Bayesian":[177],"optimization":[178],"(BO)":[179],"determine":[181],"order":[185],"better":[187],"results.":[189],"Additionally,":[190],"fault-tolerant":[194],"structure":[195],"option":[198],"users,":[200],"only":[202],"occupies":[203],"little":[204],"area":[205],"around":[206],"channels,":[208,239],"significantly":[210,232],"improves":[211],"reliability":[213,242],"against":[214],"blockage":[215],"defects.":[216],"Experimental":[217],"results":[218],"demonstrate":[219],"all":[227],"boundaries,":[231],"usage,":[236],"shorten":[237],"improve":[241],"compared":[243],"baseline":[245],"methods.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}