{"id":"https://openalex.org/W4404493796","doi":"https://doi.org/10.1145/3674658.3674670","title":"Prognostic Significance and Functional Implications of PPP1R12B in Acute Myeloid Leukemia","display_name":"Prognostic Significance and Functional Implications of PPP1R12B in Acute Myeloid Leukemia","publication_year":2024,"publication_date":"2024-05-24","ids":{"openalex":"https://openalex.org/W4404493796","doi":"https://doi.org/10.1145/3674658.3674670"},"language":"en","primary_location":{"id":"doi:10.1145/3674658.3674670","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3674658.3674670","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 16th International Conference on Bioinformatics and Biomedical Technology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ruifeng Wang","orcid":"https://orcid.org/0009-0001-6061-9505"},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruifeng Wang","raw_affiliation_strings":["school of nursing, Shaanxi University of Chinese Medicine, , Xianyang, Shaanxi, China"],"raw_orcid":"https://orcid.org/0009-0001-6061-9505","affiliations":[{"raw_affiliation_string":"school of nursing, Shaanxi University of Chinese Medicine, , Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086476592","display_name":"Fengjiao Chang","orcid":"https://orcid.org/0009-0001-1780-684X"},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengjiao Chang","raw_affiliation_strings":["School of Nursing, Shaanxi University of Chinese Medicine, , Xianyang, Shaanxi, China"],"raw_orcid":"https://orcid.org/0009-0001-1780-684X","affiliations":[{"raw_affiliation_string":"School of Nursing, Shaanxi University of Chinese Medicine, , Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110129285","display_name":"Xiaolan Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolan Guo","raw_affiliation_strings":["School of Nursing, Shaanxi University of Chinese Medicine, , Xianyang, Shaanxi, China"],"raw_orcid":"https://orcid.org/0009-0007-2891-4946","affiliations":[{"raw_affiliation_string":"School of Nursing, Shaanxi University of Chinese Medicine, , Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I75920027"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I75920027"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33434152,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"63","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"Myeloid leukemia","score":0.8245072364807129},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4860821068286896},{"id":"https://openalex.org/keywords/leukemia","display_name":"Leukemia","score":0.41996851563453674},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41258007287979126},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.3364066481590271},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2829267978668213}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.8245072364807129},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4860821068286896},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.41996851563453674},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41258007287979126},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3364066481590271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2829267978668213}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3674658.3674670","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3674658.3674670","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 16th International Conference on Bioinformatics and Biomedical Technology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46000000834465027}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W2023446937","https://openalex.org/W2029867827","https://openalex.org/W2081107387","https://openalex.org/W2110943179","https://openalex.org/W2149687593","https://openalex.org/W2602770731","https://openalex.org/W2612428976","https://openalex.org/W2738767990","https://openalex.org/W2759296504","https://openalex.org/W2806085070","https://openalex.org/W2901163520","https://openalex.org/W2901354583","https://openalex.org/W3091935721","https://openalex.org/W3162094205","https://openalex.org/W3194892380","https://openalex.org/W4210799171","https://openalex.org/W4225303742","https://openalex.org/W4313454313","https://openalex.org/W4318754478","https://openalex.org/W4388632382"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W2990397977","https://openalex.org/W2364732766"],"abstract_inverted_index":{"Acute":[0],"Myeloid":[1],"Leukemia":[2],"(AML)":[3],"is":[4,77,87,99],"a":[5,31,118,125],"life-threatening":[6],"hematologic":[7],"malignancy":[8],"characterized":[9],"by":[10],"rapid":[11],"proliferation":[12],"of":[13,27,33,60,147,152],"abnormal":[14],"myeloid":[15],"cells.":[16],"This":[17],"study":[18,55,122],"employs":[19],"comprehensive":[20],"bioinformatics":[21],"analyses":[22,95],"to":[23,84,134],"elucidate":[24],"the":[25,28,34,54,57,145,150],"role":[26],"PPP1R12B":[29,61,76,98,129,148],"gene,":[30],"member":[32],"myosin":[35],"phosphatase":[36],"regulatory":[37],"subunits,":[38],"in":[39,62,80,101,138,149],"AML.":[40,157],"Utilizing":[41],"data":[42],"from":[43],"The":[44,121],"Cancer":[45],"Genome":[46],"Atlas":[47],"(TCGA)":[48],"and":[49,64,70,86,111],"Gene":[50],"Expression":[51],"Omnibus":[52],"(GEO),":[53],"investigates":[56],"expression":[58,130],"levels":[59],"AML":[63,81,139],"correlates":[65],"these":[66],"with":[67,89,131],"patient":[68],"survival":[69,136],"clinical":[71,132],"outcomes.":[72],"Results":[73],"indicate":[74],"that":[75,97],"significantly":[78],"upregulated":[79],"cases":[82],"compared":[83],"controls":[85],"associated":[88],"poor":[90],"prognosis.":[91],"Further,":[92],"functional":[93],"enrichment":[94],"reveal":[96],"involved":[100],"key":[102],"processes":[103],"such":[104],"as":[105,117],"chromatin":[106],"remodeling,":[107],"DNA":[108],"damage":[109],"repair,":[110],"cell":[112],"division,":[113],"highlighting":[114],"its":[115],"potential":[116],"therapeutic":[119],"target.":[120],"also":[123],"constructs":[124],"predictive":[126],"nomogram":[127],"integrating":[128],"parameters":[133],"forecast":[135],"rates":[137],"patients.":[140],"These":[141],"findings":[142],"advocate":[143],"for":[144,156],"inclusion":[146],"development":[151],"personalized":[153],"treatment":[154],"strategies":[155]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
