{"id":"https://openalex.org/W4404493791","doi":"https://doi.org/10.1145/3674658.3674668","title":"PAX9 Overexpression in Lung Adenocarcinoma and Promotes Cancer Progression","display_name":"PAX9 Overexpression in Lung Adenocarcinoma and Promotes Cancer Progression","publication_year":2024,"publication_date":"2024-05-24","ids":{"openalex":"https://openalex.org/W4404493791","doi":"https://doi.org/10.1145/3674658.3674668"},"language":"en","primary_location":{"id":"doi:10.1145/3674658.3674668","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3674658.3674668","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 16th International Conference on Bioinformatics and Biomedical Technology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100386785","display_name":"Dandan Zhang","orcid":"https://orcid.org/0009-0001-9568-3128"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dandan Zhang","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110216895","display_name":"Yuxin Du","orcid":"https://orcid.org/0009-0009-1560-3908"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxin Du","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115603381","display_name":"Wenhua Zhang","orcid":"https://orcid.org/0009-0002-4250-1674"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhua Zhang","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103725845","display_name":"Xiaoshuai Ren","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoshuai Ren","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113350457","display_name":"Changyun Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changyun Huang","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083589430","display_name":"Fengwu Qiu","orcid":"https://orcid.org/0000-0002-3574-8946"},"institutions":[{"id":"https://openalex.org/I4210144323","display_name":"Wuhan Blood Center","ror":"https://ror.org/0443rmh76","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210144323"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengwu Qiu","raw_affiliation_strings":["Wuhan Blood Center, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"Wuhan Blood Center, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4210144323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101946633","display_name":"Jun Zhou","orcid":"https://orcid.org/0000-0003-4380-735X"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Zhou","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101768753","display_name":"Xiaoyu Zhang","orcid":"https://orcid.org/0009-0000-1658-3616"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Zhang","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I43922553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5100386785"],"corresponding_institution_ids":["https://openalex.org/I43922553"],"apc_list":null,"apc_paid":null,"fwci":0.2339,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59149131,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"53","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9857000112533569,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5821356773376465},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"Adenocarcinoma","score":0.5767873525619507},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5551655888557434},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4143039882183075},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41028618812561035},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.33481520414352417},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.2898070514202118},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.18965750932693481}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5821356773376465},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5767873525619507},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5551655888557434},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4143039882183075},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41028618812561035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33481520414352417},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2898070514202118},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18965750932693481}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3674658.3674668","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3674658.3674668","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 16th International Conference on Bioinformatics and Biomedical Technology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2969532097"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Paired":[0],"box":[1],"9":[2],"(PAX9)":[3],"is":[4,32,47],"a":[5,15,19,33,43],"transcription":[6],"factor":[7],"of":[8,45,103,114,130,154,163,178,183,199],"the":[9,29,63,67,71,101,128,149,158,175,180,196],"PAX":[10],"family":[11],"functioning":[12],"as":[13],"both":[14],"transcriptional":[16],"activator":[17],"and":[18,96,143,148,160,186],"repressor.":[20],"At":[21,70],"this":[22],"stage":[23],"it":[24,74],"has":[25],"been":[26],"demonstrated":[27,120],"that":[28,77,124,152,170],"PAX9":[30,50,78,104,115,125,155],"gene":[31,35],"key":[34],"in":[36,42,56,82,105,171],"embryonic":[37],"development,":[38],"but":[39],"its":[40],"function":[41],"variety":[44],"cancers":[46],"still":[48],"unknown.":[49],"was":[51,75,80,116,119],"found":[52,76],"to":[53,62,88],"be":[54],"overexpressed":[55],"lung":[57,83,90],"adenocarcinoma":[58],"(LUAD)":[59],"samples":[60],"according":[61],"TCGA":[64],"database":[65],"on":[66],"Bioinformatics":[68],"website.":[69],"same":[72],"time,":[73],"expression":[79,177],"higher":[81,176,181],"cancer":[84],"cell":[85,92,109,135,165,173],"lines":[86,93],"compared":[87],"normal":[89],"epithelial":[91],"by":[94,121,133],"qRT-PCR":[95],"Western":[97],"Blot.":[98],"To":[99],"investigate":[100],"role":[102],"LUAD,":[106],"an":[107],"A549":[108,131,164,172],"line":[110],"with":[111],"stable":[112],"knockdown":[113,153],"constructed.":[117],"It":[118],"EdU":[122],"assay":[123,142,145],"could":[126],"promote":[127],"proliferation":[129],"cells":[132],"promoting":[134],"cycle":[136],"changes.":[137],"In":[138],"parallel,":[139],"wound":[140],"healing":[141],"transwell":[144],"were":[146],"performed,":[147],"results":[150,168],"showed":[151,169],"significantly":[156],"inhibited":[157],"migration":[159,185],"invasion":[161],"ability":[162,182],"line.":[166],"Our":[167,188],"lines,":[174],"PAX9,":[179],"proliferation,":[184],"invasion.":[187],"study":[189],"may":[190],"provide":[191],"new":[192],"therapeutic":[193],"ideas":[194],"for":[195],"future":[197],"treatment":[198],"LUAD.":[200]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
