{"id":"https://openalex.org/W4400116316","doi":"https://doi.org/10.1145/3665689.3665770","title":"Screening and identification of the core genes and drug targets in COVID-19 and coronary artery disease by integrated bioinformatics","display_name":"Screening and identification of the core genes and drug targets in COVID-19 and coronary artery disease by integrated bioinformatics","publication_year":2024,"publication_date":"2024-01-26","ids":{"openalex":"https://openalex.org/W4400116316","doi":"https://doi.org/10.1145/3665689.3665770"},"language":"en","primary_location":{"id":"doi:10.1145/3665689.3665770","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3665689.3665770","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 4th International Conference on Bioinformatics and Intelligent Computing","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102996058","display_name":"Xiaolan Zhang","orcid":"https://orcid.org/0009-0006-5619-3894"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaolan Zhang","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059270708","display_name":"Yudie Wang","orcid":"https://orcid.org/0009-0006-0394-0040"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yudie Wang","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060441942","display_name":"Shuai Xiong","orcid":"https://orcid.org/0009-0008-2562-9354"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Xiong","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102974342","display_name":"Ying Feng","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Feng","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006796176","display_name":"Lixia Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lixia Zhou","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102782629","display_name":"Xian Li","orcid":"https://orcid.org/0009-0001-6906-9271"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xian Li","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102026195","display_name":"Zhi-Hui Luo","orcid":"https://orcid.org/0000-0001-7282-4744"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihui Luo","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036869119","display_name":"Jingjiao Zhou","orcid":"https://orcid.org/0000-0003-3861-0261"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjiao Zhou","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5102996058"],"corresponding_institution_ids":["https://openalex.org/I43922553"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11220899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"485","last_page":"490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9664000272750854,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9664000272750854,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9430000185966492,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"Coronary artery disease","score":0.6777923107147217},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.658413827419281},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.6308812499046326},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.6162554025650024},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5097574591636658},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.506430983543396},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4328702390193939},{"id":"https://openalex.org/keywords/core","display_name":"Core (optical fiber)","score":0.4266761541366577},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41526514291763306},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.36557477712631226},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32549145817756653},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.28812000155448914},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21834495663642883},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16814395785331726},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.14770707488059998},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.08110085129737854}],"concepts":[{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6777923107147217},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.658413827419281},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6308812499046326},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6162554025650024},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5097574591636658},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.506430983543396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4328702390193939},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.4266761541366577},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41526514291763306},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36557477712631226},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32549145817756653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28812000155448914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21834495663642883},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16814395785331726},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14770707488059998},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.08110085129737854},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3665689.3665770","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3665689.3665770","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 4th International Conference on Bioinformatics and Intelligent Computing","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5299999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W2124153471","https://openalex.org/W3135564620","https://openalex.org/W3206256678","https://openalex.org/W4207080708","https://openalex.org/W4210657012","https://openalex.org/W4225586016","https://openalex.org/W4281710803","https://openalex.org/W4288038190","https://openalex.org/W4301398498","https://openalex.org/W4306933290","https://openalex.org/W4384276906","https://openalex.org/W4387647282"],"related_works":["https://openalex.org/W3158538495","https://openalex.org/W4206379684","https://openalex.org/W2898732673","https://openalex.org/W2410053581","https://openalex.org/W2383658677","https://openalex.org/W2045815042","https://openalex.org/W3123203398","https://openalex.org/W3116815879","https://openalex.org/W2092226129","https://openalex.org/W4391230627"],"abstract_inverted_index":{"The":[0],"Coronavirus":[1],"Disease":[2],"2019":[3],"(COVID-19)":[4],"is":[5,50],"attributed":[6],"to":[7,34,151],"severe":[8,36],"acute":[9],"respiratory":[10],"syndrome":[11],"coronavirus":[12],"2":[13],"(SARS-CoV-2)":[14],"infection.":[15],"Studies":[16],"found":[17,91],"that":[18,92,134,144],"SARS-CoV-2":[19],"infection":[20],"could":[21],"worsen":[22],"the":[23,29,42,93,120,145,159,199],"coronary":[24],"artery":[25],"disease":[26],"(CAD),":[27],"and":[28,48,61,72,105,117,130,154,170,172,180,184,186,206],"risk":[30],"for":[31,198,204],"CAD":[32,49,62],"patients":[33,60],"develop":[35],"COVID-19":[37,47,59,71,183,205],"would":[38],"be":[39,137],"amplified.":[40],"However,":[41],"potential":[43,177,190],"molecular":[44,178],"mechanism":[45],"between":[46],"not":[51],"clear":[52],"yet.":[53],"By":[54],"studying":[55],"transcriptomic":[56],"data":[57],"from":[58],"patients,":[63],"106":[64],"differentially":[65],"expressed":[66],"genes":[67],"(DEGs)":[68],"shared":[69],"in":[70,77,110],"CAD,":[73,185],"which":[74],"played":[75,107],"roles":[76,109],"cardiomyopathy,":[78],"citric":[79],"acid":[80],"cycle":[81],"(TCA":[82],"cycle),":[83],"apoptosis":[84],"signaling":[85,162],"pathways,":[86],"etc.":[87],"Protein\u2013protein":[88],"interaction":[89],"analyses":[90],"hub":[94,123],"genes,":[95],"EEF1B2,":[96],"COX7C,":[97],"FAU,":[98],"SNRPD2,":[99],"TOMM7,":[100],"HINT1,":[101],"ATP5ME,":[102],"ATP5PO,":[103],"LSM7,":[104],"FBL":[106],"crucial":[108],"these":[111,165],"two":[112,166],"diseases.":[113],"Transcription":[114],"factors":[115],"MYC":[116],"CTCF":[118],"regulated":[119],"expression":[121],"of":[122,126,164,182,201],"genes.":[124],"Analyses":[125],"Gene":[127],"regulatory":[128],"networks":[129],"drug-receptor":[131],"interactions":[132],"discovered":[133],"Ajmaline":[135,146,187],"might":[136],"a":[138,189],"promising":[139],"drug.":[140],"Molecular":[141],"docking":[142],"showed":[143],"had":[147],"strong":[148],"binding":[149],"activity":[150],"proteins":[152],"COX7C":[153,171],"HINT1.":[155],"In":[156],"this":[157],"study,":[158],"main":[160],"enriched":[161],"pathways":[163],"diseases":[167],"were":[168,174],"studied":[169],"HINT1":[173],"revealed":[175],"as":[176,188],"markers":[179],"targets":[181],"drug":[191],"candidate":[192],"provided":[193],"an":[194],"important":[195],"theoretical":[196],"basis":[197],"development":[200],"effective":[202],"therapies":[203],"CAD.":[207]},"counts_by_year":[],"updated_date":"2025-12-23T23:11:35.936235","created_date":"2025-10-10T00:00:00"}
