{"id":"https://openalex.org/W4400116201","doi":"https://doi.org/10.1145/3665689.3665751","title":"The Anti-tumor Effects of Ultrasonic Mechanical Force on human liver cancer cells","display_name":"The Anti-tumor Effects of Ultrasonic Mechanical Force on human liver cancer cells","publication_year":2024,"publication_date":"2024-01-26","ids":{"openalex":"https://openalex.org/W4400116201","doi":"https://doi.org/10.1145/3665689.3665751"},"language":"en","primary_location":{"id":"doi:10.1145/3665689.3665751","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3665689.3665751","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 4th International Conference on Bioinformatics and Intelligent Computing","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000510481","display_name":"Tianwen Xu","orcid":"https://orcid.org/0000-0003-2519-8140"},"institutions":[{"id":"https://openalex.org/I4210154710","display_name":"Wuxi Taihu Hospital","ror":"https://ror.org/05qp6pd10","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154710"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"T Xu","raw_affiliation_strings":["School of Nursing, Wuxi Taihu University, China and \rWuxi University, China"],"raw_orcid":"https://orcid.org/0000-0003-2519-8140","affiliations":[{"raw_affiliation_string":"School of Nursing, Wuxi Taihu University, China and \rWuxi University, China","institution_ids":["https://openalex.org/I4210154710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053250285","display_name":"L Gu","orcid":"https://orcid.org/0000-0003-3539-0953"},"institutions":[{"id":"https://openalex.org/I4210154710","display_name":"Wuxi Taihu Hospital","ror":"https://ror.org/05qp6pd10","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154710"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L Gu","raw_affiliation_strings":["School of Nursing, Wuxi Taihu University, China"],"raw_orcid":"https://orcid.org/0000-0003-3539-0953","affiliations":[{"raw_affiliation_string":"School of Nursing, Wuxi Taihu University, China","institution_ids":["https://openalex.org/I4210154710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210154710"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"370","last_page":"374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12994","display_name":"Infrared Thermography in Medicine","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9772999882698059,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ultrasonic-sensor","display_name":"Ultrasonic sensor","score":0.6629599332809448},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.47237852215766907},{"id":"https://openalex.org/keywords/ultrasonic-imaging","display_name":"Ultrasonic imaging","score":0.47176721692085266},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"Liver cancer","score":0.46994927525520325},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3820428252220154},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2868303060531616},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.2672566771507263},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2362976372241974},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.16107895970344543}],"concepts":[{"id":"https://openalex.org/C81288441","wikidata":"https://www.wikidata.org/wiki/Q20736125","display_name":"Ultrasonic sensor","level":2,"score":0.6629599332809448},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47237852215766907},{"id":"https://openalex.org/C2989478337","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Ultrasonic imaging","level":3,"score":0.47176721692085266},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.46994927525520325},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3820428252220154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2868303060531616},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.2672566771507263},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2362976372241974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16107895970344543}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3665689.3665751","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3665689.3665751","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 4th International Conference on Bioinformatics and Intelligent Computing","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8799999952316284,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1527151869","https://openalex.org/W1775189307","https://openalex.org/W1825810391","https://openalex.org/W1976375913","https://openalex.org/W1980836971","https://openalex.org/W2014840564","https://openalex.org/W2027559757","https://openalex.org/W2057263022","https://openalex.org/W2088088102","https://openalex.org/W2140236327","https://openalex.org/W2181030173","https://openalex.org/W2261881668","https://openalex.org/W2289857071","https://openalex.org/W2333194534","https://openalex.org/W2411120473","https://openalex.org/W2562043948","https://openalex.org/W2680059527","https://openalex.org/W2760803623","https://openalex.org/W2770290260","https://openalex.org/W4308544462"],"related_works":["https://openalex.org/W4256618856","https://openalex.org/W2360949490","https://openalex.org/W2377597505","https://openalex.org/W2366714167","https://openalex.org/W2389089521","https://openalex.org/W2394327059","https://openalex.org/W1976507804","https://openalex.org/W4245361752","https://openalex.org/W15099670","https://openalex.org/W2353772996"],"abstract_inverted_index":{"Malignant":[0],"tumors":[1],"(ie,":[2],"cancer)":[3],"are":[4,118],"major":[5],"public":[6],"health":[7],"problems":[8,50],"in":[9,13,30],"China":[10],"and":[11,43,79,108,124,127,152,167,174],"even":[12],"the":[14,18,21,31,40,54,74,82,168,178,182],"gable":[15],"wide.":[16],"Since":[17],"early":[19],"1970s,":[20],"anti-tumor":[22],"effects":[23],"of":[24,34,46,56,76,84,95,131,170,184],"ultrasound":[25,80],"have":[26,48],"been":[27],"widely":[28],"used":[29],"clinical":[32],"treatment":[33],"various":[35],"tumors,":[36],"mainly":[37],"relying":[38],"on":[39,165],"thermal":[41],"effect":[42],"cavitation,":[44],"both":[45],"which":[47,134],"unsolved":[49],"during":[51],"applications,":[52],"thus":[53],"use":[55,144],"ultrasonic":[57,136],"mechanical":[58,71,85,89],"mechanisms":[59],"has":[60,92],"become":[61],"a":[62,161],"possible":[63],"breakthrough.":[64],"In":[65],"2008,":[66],"it":[67],"was":[68,81],"reported":[69],"that":[70],"stress":[72,172],"inhibited":[73],"growth":[75],"tumor":[77],"cells,":[78,133],"propagation":[83],"vibrational":[86],"energy.":[87],"Ultrasonic":[88],"force":[90],"(UMF)":[91],"following":[93],"advantages":[94],"inhibiting":[96],"tumor:":[97],"1.":[98],"Low":[99],"power.":[100],"There":[101,117],"is":[102],"no":[103],"damage":[104],"to":[105,143],"normal":[106,122],"cells":[107,123,126,148,159],"surface":[109],"contact":[110],"skin;":[111],"2.":[112],"Frequency":[113],"differences":[114,120],"between":[115,121,128],"tumors.":[116],"frequency":[119,163,186],"cancer":[125,132,147],"different":[129],"types":[130],"make":[135],"therapy":[137],"more":[138],"precise.":[139],"This":[140],"study":[141],"intended":[142],"human":[145],"liver":[146],"as":[149],"experimental":[150],"subjects":[151],"found":[153],"out":[154],"their":[155],"sensitive":[156,185],"frequency.":[157],"Hepatoma":[158],"showed":[160],"significant":[162],"dependence":[164],"UMF,":[166],"changes":[169],"oxidative":[171],"level":[173],"biological":[175],"behavior":[176],"were":[177],"most":[179],"obvious":[180],"under":[181],"action":[183],"UMF":[187],"at":[188],"600":[189],"kHz.":[190]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}