{"id":"https://openalex.org/W4400116831","doi":"https://doi.org/10.1145/3665689.3665742","title":"Molecular Mechanism of Wenyang Zhenshuai Granule in Treatment of Chronic Heart Failure via Network pharmacology","display_name":"Molecular Mechanism of Wenyang Zhenshuai Granule in Treatment of Chronic Heart Failure via Network pharmacology","publication_year":2024,"publication_date":"2024-01-26","ids":{"openalex":"https://openalex.org/W4400116831","doi":"https://doi.org/10.1145/3665689.3665742"},"language":"en","primary_location":{"id":"doi:10.1145/3665689.3665742","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3665689.3665742","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 4th International Conference on Bioinformatics and Intelligent Computing","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101859934","display_name":"Cheng-hao Yang","orcid":"https://orcid.org/0009-0002-1134-8734"},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chenghao Yang","raw_affiliation_strings":["Shanghai University of Traditional Chinese Medicine Affiliated Putuo Hospital, China"],"affiliations":[{"raw_affiliation_string":"Shanghai University of Traditional Chinese Medicine Affiliated Putuo Hospital, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101773814","display_name":"Zongjun Liu","orcid":"https://orcid.org/0000-0003-1845-525X"},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zongjun Liu","raw_affiliation_strings":["Shanghai University of Traditional Chinese Medicine Affiliated Putuo Hospital, China"],"affiliations":[{"raw_affiliation_string":"Shanghai University of Traditional Chinese Medicine Affiliated Putuo Hospital, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102901089","display_name":"Huzhi Cai","orcid":"https://orcid.org/0009-0004-8085-8759"},"institutions":[{"id":"https://openalex.org/I4210104845","display_name":"First Affiliated Hospital of Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/01ffek432","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104845"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huzhi Cai","raw_affiliation_strings":["The First Affiliate Hospital of Hunan University of Chinese Medicine, China"],"affiliations":[{"raw_affiliation_string":"The First Affiliate Hospital of Hunan University of Chinese Medicine, China","institution_ids":["https://openalex.org/I4210104845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042370869","display_name":"Qing-Yang Chen","orcid":"https://orcid.org/0009-0001-3051-215X"},"institutions":[{"id":"https://openalex.org/I4210104845","display_name":"First Affiliated Hospital of Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/01ffek432","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104845"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingyang Chen","raw_affiliation_strings":["The First Affiliate Hospital of Hunan University of Chinese Medicine, China"],"affiliations":[{"raw_affiliation_string":"The First Affiliate Hospital of Hunan University of Chinese Medicine, China","institution_ids":["https://openalex.org/I4210104845"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017918669","display_name":"Xinyu Chen","orcid":"https://orcid.org/0009-0003-1434-8980"},"institutions":[{"id":"https://openalex.org/I4210104845","display_name":"First Affiliated Hospital of Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/01ffek432","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104845"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Chen","raw_affiliation_strings":["The First Affiliate Hospital of Hunan University of Chinese Medicine, China"],"affiliations":[{"raw_affiliation_string":"The First Affiliate Hospital of Hunan University of Chinese Medicine, China","institution_ids":["https://openalex.org/I4210104845"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101859934"],"corresponding_institution_ids":["https://openalex.org/I4210098460"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12757176,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"308","last_page":"316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.5828965902328491},{"id":"https://openalex.org/keywords/granule","display_name":"Granule (geology)","score":0.5734750032424927},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5690843462944031},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.540095329284668},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.39557144045829773},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3318186402320862},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.32574212551116943},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.24189963936805725},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16129860281944275},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.08661681413650513}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5828965902328491},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.5734750032424927},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5690843462944031},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.540095329284668},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39557144045829773},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3318186402320862},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32574212551116943},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.24189963936805725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16129860281944275},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08661681413650513},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3665689.3665742","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3665689.3665742","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 4th International Conference on Bioinformatics and Intelligent Computing","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2105786786","https://openalex.org/W2144184190","https://openalex.org/W2159675211","https://openalex.org/W2191641478","https://openalex.org/W2279201083","https://openalex.org/W2404266754","https://openalex.org/W2801069509","https://openalex.org/W2928665623","https://openalex.org/W2975025207","https://openalex.org/W4400064739"],"related_works":["https://openalex.org/W588655279","https://openalex.org/W2383994333","https://openalex.org/W642714463","https://openalex.org/W3087798489","https://openalex.org/W2058646078","https://openalex.org/W2099628268","https://openalex.org/W44894489","https://openalex.org/W2164703220","https://openalex.org/W55173076","https://openalex.org/W1992046973"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"predict":[2],"the":[3,13,20,56,65,74,87,93,167,189,202,214,232,251],"potential":[4,241],"pharmacological":[5,22],"mechanism":[6,168],"of":[7,15,27,39,58,90,95,107,120,169,191,205,217,236,248,253,265],"Wenyang":[8],"Zhenshuai":[9],"Granule":[10],"(WYZSG)":[11],"in":[12,92,171,250],"treatment":[14,94,252],"chronic":[16,40,96,173,208,254],"heart":[17,41,97,174,209,255],"failure":[18,42,98,175,210],"via":[19],"network":[21,57,83,237],"method.":[23],"Methods:The":[24],"active":[25,118],"components":[26,119],"WYZSG":[28,91,121,170,199,249],"were":[29,43,99,110,122],"screened":[30,44],"through":[31,45,188],"TCMSP":[32],"and":[33,86,103,143,156,181,195,229,234,243,257,263],"other":[34],"databases.":[35],"The":[36,81,117,139],"related":[37],"targets":[38,89,109,180],"Genecards,":[46],"OMIM,":[47],"Disgenet":[48],"databases,":[49],"etc.":[50,133,161],"Cytoscape3.7.2":[51],"was":[52,64,77,84],"used":[53,67,78],"to":[54,79,221],"construct":[55],"\"drugs-active":[59],"components-targets\".":[60],"And":[61],"not":[62],"only":[63],"String":[66],"for":[68,245,260],"protein-protein":[69],"interaction":[70],"network,":[71],"but":[72],"also":[73],"BisoGenet":[75],"database":[76],"supplement.":[80],"intersection":[82],"extracted":[85],"key":[88,108,137,140],"obtained.":[100],"Finally,":[101],"GO":[102],"KEGG":[104],"enrichment":[105],"analysis":[106,235],"carried":[111],"out":[112],"by":[113,211],"using":[114],"Metascape.":[115],"Results:":[116],"Quercetin,":[123],"Pachymic":[124],"acid,":[125],"Salsolinol,":[126],"1-methyl-6,7-dihydroxy-3,4-dihydroisoquinoline":[127],"monohydrate,":[128],"Ginsenoside,":[129],"Gomisin":[130],"R,":[131],"Stigmasterol,":[132],"There":[134],"are":[135],"163":[136],"targets.":[138],"biological":[141,215],"processes":[142,216],"pathway":[144],"may":[145,185,200],"include":[146],"AGE-RAGE":[147],"signaling":[148,151,159],"pathway,":[149,152,160],"HIF-1":[150],"Fluid":[153],"shear":[154],"stress":[155],"atherosclerosis,":[157],"TNF":[158],"Conclusions:":[162],"This":[163],"study":[164,247],"preliminarily":[165],"revealed":[166],"treating":[172],"with":[176,207,213],"multi":[177,179,182],"components,":[178],"pathways,":[183],"that":[184],"be":[186],"effected":[187],"regulation":[190],"complement":[192],"system,":[193],"cytokines":[194],"MAPK":[196],"signal":[197],"pathway.":[198],"improve":[201],"long-term":[203],"prognosis":[204],"patients":[206],"interfering":[212],"myocardial":[218],"cell":[219],"response":[220],"ROS":[222,226],"(reactive":[223],"oxygen":[224],"species),":[225],"metabolic":[227],"process":[228],"apoptosis.":[230],"Through":[231],"discussion":[233],"pharmacology,":[238],"it":[239],"provided":[240,258],"target":[242],"basis":[244,259],"further":[246],"failure,":[256],"clinical":[261],"development":[262],"utilization":[264],"WYZSG.":[266]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}