{"id":"https://openalex.org/W4400116379","doi":"https://doi.org/10.1145/3665689.3665738","title":"Exploration of the effect of CDC20 in the diagnosis and prognosis of gastric cancer patients from a statistical and bioinformatics-based approach","display_name":"Exploration of the effect of CDC20 in the diagnosis and prognosis of gastric cancer patients from a statistical and bioinformatics-based approach","publication_year":2024,"publication_date":"2024-01-26","ids":{"openalex":"https://openalex.org/W4400116379","doi":"https://doi.org/10.1145/3665689.3665738"},"language":"en","primary_location":{"id":"doi:10.1145/3665689.3665738","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3665689.3665738","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3665689.3665738?download=true","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 4th International Conference on Bioinformatics and Intelligent Computing","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dl.acm.org/doi/pdf/10.1145/3665689.3665738?download=true","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008305279","display_name":"Hua Ma","orcid":"https://orcid.org/0000-0002-2125-7687"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Ma","raw_affiliation_strings":["School of Science and Chemical Engineering, Ningxia Institute of Science and Technology, China"],"raw_orcid":"https://orcid.org/0000-0002-2125-7687","affiliations":[{"raw_affiliation_string":"School of Science and Chemical Engineering, Ningxia Institute of Science and Technology, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007942018","display_name":"C. Zhao","orcid":"https://orcid.org/0009-0002-8032-8083"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chengwen Zhao","raw_affiliation_strings":["School of Economics and Management, Ningxia Institute of Science and Technology, China"],"raw_orcid":"https://orcid.org/0009-0002-8032-8083","affiliations":[{"raw_affiliation_string":"School of Economics and Management, Ningxia Institute of Science and Technology, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5099636473","display_name":"Jun Ma","orcid":"https://orcid.org/0009-0004-6326-1184"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Ma","raw_affiliation_strings":["School of Information Science and Engineering, Lanzhou University, China"],"raw_orcid":"https://orcid.org/0009-0004-6326-1184","affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Lanzhou University, China","institution_ids":["https://openalex.org/I76214153"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"287","last_page":"292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9876999855041504,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.987500011920929,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6642985343933105},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.537261426448822},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4238553047180176},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.39936959743499756},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2745213508605957},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14952918887138367}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6642985343933105},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.537261426448822},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4238553047180176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39936959743499756},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2745213508605957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14952918887138367}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3665689.3665738","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3665689.3665738","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3665689.3665738?download=true","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 4th International Conference on Bioinformatics and Intelligent Computing","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1145/3665689.3665738","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3665689.3665738","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3665689.3665738?download=true","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 4th International Conference on Bioinformatics and Intelligent Computing","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7200000286102295}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4400116379.pdf"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W2130410032","https://openalex.org/W2311746741","https://openalex.org/W2811180310","https://openalex.org/W2906790633","https://openalex.org/W2921707334","https://openalex.org/W2923726323","https://openalex.org/W2934527592","https://openalex.org/W3014145665","https://openalex.org/W3083972852"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"This":[0],"study":[1],"aims":[2],"to":[3,18,79,99,256],"investigate":[4,100],"the":[5,20,25,81,86,95,101,106,115,121,135],"effect":[6],"of":[7,22,29,83,124,138,151,191,203],"cell":[8],"division":[9],"cycle":[10],"20":[11],"(CDC20)":[12],"in":[13,85,156,160,169,198,226],"gastric":[14],"cancer":[15],"(GC)":[16],"and":[17,27,35,46,88,105,118,128,182,205,237,252],"explore":[19],"impact":[21],"CDC20":[23,55,84,104,125,139,152,165,176,192,211,223,243,253],"on":[24,33],"clinicopathology":[26],"prognosis":[28,197],"GC.":[30,170],"The":[31,47,148,184,201],"data":[32],"GC":[34,89,157,199,218],"corresponding":[36],"clinical":[37,107],"traits":[38],"were":[39],"downloaded":[40],"from":[41],"Gene":[42],"Expression":[43],"Omnibus":[44],"(GEO)":[45],"Cancer":[48],"Genome":[49],"Atlas":[50],"(TCGA)":[51],"databases.":[52],"METHODS:":[53],"Firstly,":[54],"was":[56,65,112,153,166,177,193,212,224],"screened":[57,67],"by":[58,68,126],"taking":[59],"eight":[60],"topological":[61],"analysis":[62,111,145,173,186],"methods.":[63],"It":[64],"also":[66,74,133],"Lasso":[69],"regression":[70,97,172],"analysis.":[71],"Meanwhile,":[72],"we":[73,93,119],"applied":[75],"a":[76,258],"limma":[77],"package":[78],"analyze":[80],"expression":[82,149,190],"normal":[87,161],"tissues.":[90],"After":[91],"that,":[92],"used":[94],"logistic":[96],"method":[98],"relevance":[102],"between":[103],"characteristics.":[108],"Finally,":[109],"survival":[110,185],"performed":[113],"using":[114,140],"\u201csurvival\u201d":[116],"package,":[117],"analyzed":[120],"prognostic":[122,215,248],"value":[123],"single-factor":[127,204],"multi-factor":[129,206],"Cox":[130,207],"analyses.":[131],"We":[132],"studied":[134],"molecular":[136],"mechanism":[137],"multifactorial":[141],"gene":[142],"set":[143],"enrichment":[144],"(GSEA).":[146],"RESULTS:":[147],"level":[150],"significantly":[154],"higher":[155],"tissues":[158],"than":[159],"tissues,":[162],"suggesting":[163],"that":[164,175,188,210,222],"highly":[167,178],"expressed":[168],"Logistic":[171],"showed":[174,221],"associated":[179,194],"with":[180,195],"staging":[181],"grading.":[183],"revealed":[187],"high":[189],"poor":[196],"patients.":[200,219],"results":[202],"analyses":[208],"suggested":[209],"an":[213,246],"independent":[214,247],"marker":[216,249],"for":[217,250,261],"GSEA":[220],"participated":[225],"prostate":[227],"cancer,":[228,231],"small-cell":[229],"lung":[230],"GC,":[232,251],"Wingless":[233],"/":[234],"Integrated":[235],"(WNT)":[236],"T-cell":[238],"receptor":[239],"signaling":[240],"pathway.":[241],"CONCLUSION:":[242],"may":[244],"be":[245,257],"is":[254],"expected":[255],"new":[259],"target":[260],"molecularly":[262],"targeted":[263],"therapy.":[264]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}