{"id":"https://openalex.org/W4399257623","doi":"https://doi.org/10.1145/3653781.3653814","title":"Machine Learning Model for Predicting Risk of Primary Sj?gren's syndrome using N7-methylguanosine-related Genes","display_name":"Machine Learning Model for Predicting Risk of Primary Sj?gren's syndrome using N7-methylguanosine-related Genes","publication_year":2024,"publication_date":"2024-01-19","ids":{"openalex":"https://openalex.org/W4399257623","doi":"https://doi.org/10.1145/3653781.3653814"},"language":"en","primary_location":{"id":"doi:10.1145/3653781.3653814","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3653781.3653814","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Computer Vision and Deep Learning","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101413995","display_name":"Jiaoyan Li","orcid":"https://orcid.org/0009-0000-0713-6101"},"institutions":[{"id":"https://openalex.org/I4210111263","display_name":"The First Hospital of Changsha","ror":"https://ror.org/01sy5t684","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111263"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiaoyan Li","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology The First Hospital of Changsha, China"],"raw_orcid":"https://orcid.org/0009-0000-0713-6101","affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology The First Hospital of Changsha, China","institution_ids":["https://openalex.org/I4210111263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041194463","display_name":"Kaihong Xie","orcid":"https://orcid.org/0009-0005-8305-370X"},"institutions":[{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaihong Xie","raw_affiliation_strings":["Department of Oncology Affiliated Hospital of Xiangnan University, China"],"raw_orcid":"https://orcid.org/0009-0005-8305-370X","affiliations":[{"raw_affiliation_string":"Department of Oncology Affiliated Hospital of Xiangnan University, China","institution_ids":["https://openalex.org/I43081956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014226142","display_name":"Tan Tao","orcid":"https://orcid.org/0009-0002-7853-7038"},"institutions":[{"id":"https://openalex.org/I49835588","display_name":"Macao Polytechnic University","ror":"https://ror.org/02sf5td35","country_code":"MO","type":"education","lineage":["https://openalex.org/I49835588"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Tao Tan","raw_affiliation_strings":["Faulty of Applied Sciences Macao Polytechnic University, China"],"raw_orcid":"https://orcid.org/0009-0002-7853-7038","affiliations":[{"raw_affiliation_string":"Faulty of Applied Sciences Macao Polytechnic University, China","institution_ids":["https://openalex.org/I49835588"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100611748","display_name":"Hui Xie","orcid":"https://orcid.org/0000-0002-8490-1695"},"institutions":[{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Xie","raw_affiliation_strings":["Department of Radiotherapy Affiliated Hospital of Xiangnan University, China"],"raw_orcid":"https://orcid.org/0000-0002-8490-1695","affiliations":[{"raw_affiliation_string":"Department of Radiotherapy Affiliated Hospital of Xiangnan University, China","institution_ids":["https://openalex.org/I43081956"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101413995"],"corresponding_institution_ids":["https://openalex.org/I4210111263"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11370424,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.987500011920929,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9815000295639038,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pathogenesis","display_name":"Pathogenesis","score":0.6351868510246277},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5717707872390747},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5533480644226074},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5451189875602722},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42221054434776306},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.38114285469055176},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3375094532966614},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23632082343101501}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6351868510246277},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5717707872390747},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5533480644226074},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5451189875602722},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42221054434776306},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38114285469055176},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3375094532966614},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23632082343101501}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3653781.3653814","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3653781.3653814","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Computer Vision and Deep Learning","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Quality Education","score":0.49000000953674316,"id":"https://metadata.un.org/sdg/4"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1985562962","https://openalex.org/W1996076856","https://openalex.org/W1997892786","https://openalex.org/W2054886315","https://openalex.org/W2119125670","https://openalex.org/W2123879591","https://openalex.org/W2289016582","https://openalex.org/W2798003679","https://openalex.org/W2886522935","https://openalex.org/W2932978272","https://openalex.org/W2946936700","https://openalex.org/W2947348548","https://openalex.org/W2950735445","https://openalex.org/W2971904993","https://openalex.org/W2977306144","https://openalex.org/W2990439770","https://openalex.org/W3091214020","https://openalex.org/W3096658347","https://openalex.org/W3217242438","https://openalex.org/W4213081200","https://openalex.org/W4229451650","https://openalex.org/W4315703294","https://openalex.org/W4366090423","https://openalex.org/W4387741193","https://openalex.org/W4387956771","https://openalex.org/W4389099651","https://openalex.org/W4389614432","https://openalex.org/W4390665419","https://openalex.org/W4391116835"],"related_works":["https://openalex.org/W2365906682","https://openalex.org/W2356836538","https://openalex.org/W2388744202","https://openalex.org/W4394738710","https://openalex.org/W2390136389","https://openalex.org/W2370452961","https://openalex.org/W2361179295","https://openalex.org/W2384962392","https://openalex.org/W2417892315","https://openalex.org/W2349363628"],"abstract_inverted_index":{"The":[0,148],"current":[1,314],"study":[2,267,315],"aimed":[3],"to":[4,41,82,135,176,199,212],"delve":[5],"deeper":[6],"into":[7,202,319],"the":[8,16,33,56,74,109,144,152,166,179,191,203,214,228,258,263,269,313,320,344,347],"intricate":[9],"role":[10,248,271,293,321],"of":[11,20,35,54,59,146,185,206,216,227,262,272,322,338,349],"N7-methylguanosine":[12],"(m7G)":[13],"regulators":[14,274,279,327],"in":[15,102,127,165,173,178,220,249,257,275,294,328],"etiology":[17,259],"and":[18,37,44,49,73,97,106,163,182,232,260,301,325],"pathogenesis":[19],"primary":[21],"Sj\u00f6gren's":[22],"syndrome":[23],"(PSS).":[24],"PSS":[25,60,128,186,221,236,250,276,329,339,355],"is":[26],"a":[27,137,224,246],"chronic":[28],"autoimmune":[29],"disease":[30],"characterized":[31],"by":[32],"inflammation":[34],"salivary":[36],"lacrimal":[38],"glands,":[39],"leading":[40],"dry":[42],"eyes":[43],"mouth.":[45],"Despite":[46],"its":[47,171,255,326],"prevalence":[48],"impact":[50],"on":[51,151],"patient":[52],"quality":[53],"life,":[55],"underlying":[57,235],"mechanisms":[58,234],"remain":[61],"incompletely":[62],"understood.":[63],"To":[64],"address":[65],"this":[66,308],"knowledge":[67],"gap,":[68],"we":[69,92,117,189,296],"utilized":[70],"bioinformatics":[71],"techniques":[72],"powerful":[75],"extreme":[76],"gradient":[77],"boosting":[78],"decision":[79],"tree":[80],"algorithm":[81],"identify":[83],"key":[84],"m7G-related":[85,121],"genes":[86,122,131],"from":[87],"publicly":[88],"available":[89],"datasets.":[90],"Specifically,":[91,265],"analyzed":[93],"datasets":[94],"GSE7451,":[95],"GSE40611,":[96],"GSE84844,":[98],"which":[99],"are":[100,124],"rich":[101],"genetic":[103],"expression":[104],"data":[105],"accessible":[107],"through":[108,251],"Gene":[110],"Expression":[111],"Omnibus":[112],"database.":[113],"From":[114],"these":[115],"datasets,":[116],"identified":[118,153],"six":[119],"crucial":[120,270],"that":[123,140,241],"potentially":[125,281],"involved":[126],"pathogenesis.":[129,237,277,330],"These":[130,278],"were":[132],"then":[133],"employed":[134,190],"develop":[136,298],"prediction":[138],"model":[139],"can":[141,297],"accurately":[142],"assess":[143,213],"risk":[145,183],"PSS.":[147,207],"model,":[149],"based":[150],"genes,":[154],"showed":[155],"promising":[156],"results":[157],"with":[158,307],"high":[159],"accuracy,":[160],"AUC,":[161],"sensitivity,":[162],"specificity":[164],"training":[167],"set.":[168],"This":[169,208],"indicates":[170],"potential":[172,233],"clinical":[174],"settings":[175],"aid":[177],"early":[180],"diagnosis":[181],"stratification":[184],"patients.":[187,356],"Furthermore,":[188],"single-sample":[192],"gene":[193],"set":[194],"enrichment":[195],"analysis":[196],"(ssGSEA)":[197],"method":[198],"gain":[200],"insights":[201,318],"immune":[204,217,229],"landscape":[205],"approach":[209],"allowed":[210],"us":[211],"abundance":[215],"infiltration":[218],"cells":[219],"samples,":[222],"providing":[223],"comprehensive":[225],"understanding":[226,291,337],"response":[230],"patterns":[231],"Our":[238,331],"findings":[239,332],"suggest":[240],"m7G":[242,273,323],"methylation":[243,324],"may":[244],"play":[245],"pivotal":[247],"immune-mediated":[252],"mechanisms,":[253],"indicating":[254],"importance":[256],"progression":[261],"disease.":[264,310],"our":[266,336],"highlights":[268],"could":[280],"serve":[282],"as":[283],"therapeutic":[284],"targets":[285],"for":[286,305,346,354],"future":[287],"immunotherapy":[288],"strategies.":[289],"By":[290],"their":[292],"PSS,":[295],"more":[299,350],"targeted":[300],"effective":[302,351],"treatment":[303,352],"options":[304],"patients":[306],"debilitating":[309],"In":[311],"conclusion,":[312],"provides":[316],"valuable":[317],"not":[333],"only":[334],"deepen":[335],"immunology":[340],"but":[341],"also":[342],"pave":[343],"way":[345],"development":[348],"strategies":[353]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}