{"id":"https://openalex.org/W4393969752","doi":"https://doi.org/10.1145/3644116.3644333","title":"Synthesis, Cell Proliferation, and Migration Inhibition Activity of Niclosamide Derivatives Fused with Computer Image Processing","display_name":"Synthesis, Cell Proliferation, and Migration Inhibition Activity of Niclosamide Derivatives Fused with Computer Image Processing","publication_year":2023,"publication_date":"2023-10-20","ids":{"openalex":"https://openalex.org/W4393969752","doi":"https://doi.org/10.1145/3644116.3644333"},"language":"en","primary_location":{"id":"doi:10.1145/3644116.3644333","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3644116.3644333","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2023 4th International Symposium on Artificial Intelligence for Medicine Science","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102761683","display_name":"Chenhao Zhu","orcid":"https://orcid.org/0009-0006-7167-1532"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chenhao Zhu","raw_affiliation_strings":["School of Public Health, Wuhan University of Science and Technology, China"],"raw_orcid":"https://orcid.org/0009-0006-7167-1532","affiliations":[{"raw_affiliation_string":"School of Public Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033427852","display_name":"Hao Che","orcid":"https://orcid.org/0009-0005-6275-673X"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Che","raw_affiliation_strings":["School of Public Health, Wuhan University of Science and Technology, China"],"raw_orcid":"https://orcid.org/0009-0005-6275-673X","affiliations":[{"raw_affiliation_string":"School of Public Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050892072","display_name":"An Yan","orcid":"https://orcid.org/0009-0002-9650-5996"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"An Yan","raw_affiliation_strings":["School of Public Health, Wuhan University of Science and Technology, China"],"raw_orcid":"https://orcid.org/0009-0002-9650-5996","affiliations":[{"raw_affiliation_string":"School of Public Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003233387","display_name":"Xia Liu","orcid":"https://orcid.org/0009-0006-4191-1195"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Liu","raw_affiliation_strings":["School of Public Health, Wuhan University of Science and Technology, China"],"raw_orcid":"https://orcid.org/0009-0006-4191-1195","affiliations":[{"raw_affiliation_string":"School of Public Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103255427","display_name":"Shujian Liu","orcid":"https://orcid.org/0009-0002-3251-4308"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyi Liu","raw_affiliation_strings":["School of Public Health, Wuhan University of Science and Technology, China"],"raw_orcid":"https://orcid.org/0009-0002-3251-4308","affiliations":[{"raw_affiliation_string":"School of Public Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028693758","display_name":"Yuxi Jia","orcid":"https://orcid.org/0009-0007-9904-6795"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxi Jia","raw_affiliation_strings":["School of Public Health, Wuhan University of Science and Technology, China"],"raw_orcid":"https://orcid.org/0009-0007-9904-6795","affiliations":[{"raw_affiliation_string":"School of Public Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028522216","display_name":"Yajun Chen","orcid":"https://orcid.org/0009-0003-5005-2917"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yajun Chen","raw_affiliation_strings":["School of Public Health, Wuhan University of Science and Technology, China"],"raw_orcid":"https://orcid.org/0009-0003-5005-2917","affiliations":[{"raw_affiliation_string":"School of Public Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5102761683"],"corresponding_institution_ids":["https://openalex.org/I43922553"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18197649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1286","last_page":"1290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niclosamide","display_name":"Niclosamide","score":0.9151959419250488},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.5796946287155151},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.46601489186286926},{"id":"https://openalex.org/keywords/image-processing","display_name":"Image processing","score":0.4410002827644348},{"id":"https://openalex.org/keywords/cell-migration","display_name":"Cell migration","score":0.43865767121315},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40922287106513977},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.40900087356567383},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.38534417748451233},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.3488043546676636},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.2936129570007324},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2168891429901123},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18259984254837036}],"concepts":[{"id":"https://openalex.org/C2776306103","wikidata":"https://www.wikidata.org/wiki/Q418523","display_name":"Niclosamide","level":2,"score":0.9151959419250488},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5796946287155151},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46601489186286926},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.4410002827644348},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.43865767121315},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40922287106513977},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40900087356567383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38534417748451233},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.3488043546676636},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.2936129570007324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2168891429901123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18259984254837036},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3644116.3644333","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3644116.3644333","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2023 4th International Symposium on Artificial Intelligence for Medicine Science","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W1600900166","https://openalex.org/W2026864697","https://openalex.org/W4231245191","https://openalex.org/W4290961128"],"related_works":["https://openalex.org/W2350049107","https://openalex.org/W2364200453","https://openalex.org/W2373536598","https://openalex.org/W2363029350","https://openalex.org/W2386493800","https://openalex.org/W2197604154","https://openalex.org/W751460208","https://openalex.org/W2363919631","https://openalex.org/W1986897981","https://openalex.org/W2537202170"],"abstract_inverted_index":{"Four":[0],"derivatives":[1,121],"of":[2,15,27,33,40,62,83,90,103,119,153],"niclosamide":[3,46,84],"were":[4,22],"designed":[5],"and":[6,13,56,101,109,128,140,147,151],"synthesized.":[7],"Their":[8],"inhibitory":[9,25,51],"effects":[10],"on":[11,30,53],"proliferation":[12,32,55,139],"migration":[14,141],"human":[16],"breast":[17],"cancer":[18],"cell":[19,54,138],"line":[20],"MDA-MB-231":[21,34],"studied.":[23],"The":[24,126],"activity":[26,143],"four":[28],"compounds":[29],"the":[31,49,81,88,99,116,137,149],"cells":[35,154],"is":[36,65],"better":[37],"than":[38],"that":[39],"niclosamide,":[41],"among":[42],"which":[43],"compound":[44,71],"5a":[45],"nicotinate":[47],"has":[48],"strongest":[50],"effect":[52],"migration,":[57],"with":[58],"an":[59],"IC50":[60],"value":[61],"11.489\u03bcm.":[63],"It":[64],"expected":[66],"to":[67,85,93,115],"become":[68],"a":[69,112,156],"candidate":[70],"for":[72],"further":[73],"preclinical":[74],"in":[75,122,144,158],"vivo":[76],"research.":[77],"This":[78,95],"article":[79,96,134],"uses":[80],"method":[82],"comprehensively":[86],"describe":[87],"application":[89,100],"computer":[91,123,145,159],"images":[92],"derivatives.":[94],"briefly":[97],"describes":[98],"effectiveness":[102],"anti-tumor":[104],"therapy":[105],"through":[106],"image":[107,124],"processing,":[108],"then":[110],"provides":[111],"comprehensive":[113],"introduction":[114],"synthesis":[117],"experiment":[118],"chloramphenicol":[120],"processing.":[125],"analysis":[127],"results":[129],"are":[130],"presented.":[131],"Finally,":[132],"this":[133],"mainly":[135],"introduces":[136],"inhibition":[142],"images,":[146],"simulates":[148],"observation":[150],"research":[152],"under":[155],"microscope":[157],"images.":[160]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
