{"id":"https://openalex.org/W4392393687","doi":"https://doi.org/10.1145/3640900.3640904","title":"A dual-function microfluidic chip for single-cell monoclonal antibody affinity screening and functional screening","display_name":"A dual-function microfluidic chip for single-cell monoclonal antibody affinity screening and functional screening","publication_year":2024,"publication_date":"2024-01-12","ids":{"openalex":"https://openalex.org/W4392393687","doi":"https://doi.org/10.1145/3640900.3640904"},"language":"en","primary_location":{"id":"doi:10.1145/3640900.3640904","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3640900.3640904","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 14th International Conference on Bioscience, Biochemistry and Bioinformatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087928843","display_name":"Jiyu Xi","orcid":"https://orcid.org/0009-0005-2159-9969"},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiyu Xi","raw_affiliation_strings":["Department of Biomedical Engineering, Beijing Institute of Technology, China"],"raw_orcid":"https://orcid.org/0009-0005-2159-9969","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Beijing Institute of Technology, China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035163285","display_name":"Zewen Wei","orcid":"https://orcid.org/0000-0002-2608-5802"},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zewen Wei","raw_affiliation_strings":["Department of Biomedical Engineering, Beijing Institute of Technology, China"],"raw_orcid":"https://orcid.org/0000-0002-2608-5802","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Beijing Institute of Technology, China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005328827","display_name":"Z. G. Li","orcid":null},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zixi Li","raw_affiliation_strings":["Department of Biomedical Engineering, Beijing Institute of Technology, China"],"raw_orcid":"https://orcid.org/0009-0003-8183-1374","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Beijing Institute of Technology, China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051674098","display_name":"Zhanhui Geng","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhanhui Geng","raw_affiliation_strings":["Institute of System and Engineering, Academy of Military Sciences of People's Liberation Army, China"],"raw_orcid":"https://orcid.org/0009-0008-0818-0882","affiliations":[{"raw_affiliation_string":"Institute of System and Engineering, Academy of Military Sciences of People's Liberation Army, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03642688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"44","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-antibody","display_name":"Monoclonal antibody","score":0.9337029457092285},{"id":"https://openalex.org/keywords/cell-fusion","display_name":"Cell fusion","score":0.6570169925689697},{"id":"https://openalex.org/keywords/microfluidic-chip","display_name":"Microfluidic chip","score":0.6268842220306396},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"High-throughput screening","score":0.5841280221939087},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.5123944878578186},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.49360954761505127},{"id":"https://openalex.org/keywords/monoclonal","display_name":"Monoclonal","score":0.49311181902885437},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.46448737382888794},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.38415828347206116},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37551432847976685},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.36866313219070435},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.30457428097724915},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.28338363766670227},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2488510012626648},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.20962131023406982},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.14451715350151062},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11352121829986572},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.10055753588676453}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.9337029457092285},{"id":"https://openalex.org/C92488253","wikidata":"https://www.wikidata.org/wiki/Q56592403","display_name":"Cell fusion","level":3,"score":0.6570169925689697},{"id":"https://openalex.org/C2988198817","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Microfluidic chip","level":3,"score":0.6268842220306396},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.5841280221939087},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.5123944878578186},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.49360954761505127},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.49311181902885437},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.46448737382888794},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.38415828347206116},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37551432847976685},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36866313219070435},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30457428097724915},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.28338363766670227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2488510012626648},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20962131023406982},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.14451715350151062},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11352121829986572},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.10055753588676453},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3640900.3640904","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3640900.3640904","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2024 14th International Conference on Bioscience, Biochemistry and Bioinformatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1980244222","https://openalex.org/W1992274022","https://openalex.org/W2066560754","https://openalex.org/W2527905628","https://openalex.org/W2901042166","https://openalex.org/W3145552005","https://openalex.org/W3180923637"],"related_works":["https://openalex.org/W4244444919","https://openalex.org/W2058246061","https://openalex.org/W2356576053","https://openalex.org/W2060742235","https://openalex.org/W4367182701","https://openalex.org/W2056291978","https://openalex.org/W2078604053","https://openalex.org/W4205661130","https://openalex.org/W196135637","https://openalex.org/W3086568001"],"abstract_inverted_index":{"Monoclonal":[0],"antibodies(mAb),":[1],"currently":[2],"the":[3,32],"largest":[4],"category":[5],"of":[6,34,43,87],"biopharmaceuticals,":[7],"are":[8],"widely":[9],"used":[10],"due":[11],"to":[12,46],"their":[13],"high":[14,69],"specificity":[15],"and":[16,40,68,83,104],"low":[17,66],"side":[18],"effects.":[19],"The":[20],"main":[21],"method":[22],"for":[23],"producing":[24],"monoclonal":[25,88],"antibodies":[26,89],"is":[27],"hybridoma":[28,48,92],"technology,":[29],"which":[30],"involves":[31],"fusion":[33],"B":[35],"cells":[36,39,49],"with":[37,50],"myeloma":[38],"a":[41,74],"series":[42],"screening":[44,57,82,86,98],"steps":[45],"obtain":[47],"good":[51],"functional":[52,84],"activity.":[53],"However,":[54],"traditional":[55],"cell":[56,101],"methods":[58],"have":[59],"limitations":[60],"such":[61],"as":[62],"long":[63],"cycle":[64],"times,":[65],"throughput,":[67,103],"cost.":[70],"In":[71],"this":[72],"study,":[73],"microfluidic":[75],"chip":[76,95],"was":[77],"invented":[78],"that":[79],"enables":[80],"affinity":[81],"activity":[85],"based":[90],"on":[91],"cells.":[93],"This":[94],"significantly":[96],"reduces":[97,105],"time,":[99],"improves":[100],"handling":[102],"costs.":[106]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
