{"id":"https://openalex.org/W4387346431","doi":"https://doi.org/10.1145/3584371.3613066","title":"A Model of Cell Population Dynamics in Skeletal Muscle Regeneration","display_name":"A Model of Cell Population Dynamics in Skeletal Muscle Regeneration","publication_year":2023,"publication_date":"2023-09-03","ids":{"openalex":"https://openalex.org/W4387346431","doi":"https://doi.org/10.1145/3584371.3613066"},"language":"en","primary_location":{"id":"doi:10.1145/3584371.3613066","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3584371.3613066","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3584371.3613066","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dl.acm.org/doi/pdf/10.1145/3584371.3613066","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093003474","display_name":"Renad Al-Ghazawi","orcid":"https://orcid.org/0009-0006-9331-6515"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Renad Al-Ghazawi","raw_affiliation_strings":["University of Ottawa, Ottawa, Ontario, Canada"],"raw_orcid":"https://orcid.org/0009-0006-9331-6515","affiliations":[{"raw_affiliation_string":"University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009680404","display_name":"Theodore J. Perkins","orcid":"https://orcid.org/0000-0002-6622-8003"},"institutions":[{"id":"https://openalex.org/I2800722420","display_name":"Ottawa Hospital","ror":"https://ror.org/03c62dg59","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800722420"]},{"id":"https://openalex.org/I4388482656","display_name":"Ottawa Hospital Research Institute","ror":"https://ror.org/05jtef216","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I153718931","https://openalex.org/I2800722420","https://openalex.org/I4388482656"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Theodore J. Perkins","raw_affiliation_strings":["Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0002-6622-8003","affiliations":[{"raw_affiliation_string":"Ottawa Hospital Research Institute, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I2800722420","https://openalex.org/I4388482656"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001145592","display_name":"Xiaojian Shao","orcid":"https://orcid.org/0000-0002-3044-621X"},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Xiaojian Shao","raw_affiliation_strings":["National Research Council of Canada, Ottawa, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0002-3044-621X","affiliations":[{"raw_affiliation_string":"National Research Council of Canada, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I4210159778"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5093003474"],"corresponding_institution_ids":["https://openalex.org/I153718931"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29472699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9607999920845032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.6013215184211731},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"Skeletal muscle","score":0.5645946264266968},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5560243129730225},{"id":"https://openalex.org/keywords/regeneration","display_name":"Regeneration (biology)","score":0.5498487949371338},{"id":"https://openalex.org/keywords/muscular-dystrophy","display_name":"Muscular dystrophy","score":0.5328795313835144},{"id":"https://openalex.org/keywords/duchenne-muscular-dystrophy","display_name":"Duchenne muscular dystrophy","score":0.5226873159408569},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5045033693313599},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.48857054114341736},{"id":"https://openalex.org/keywords/pooling","display_name":"Pooling","score":0.45865389704704285},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37545353174209595},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3736467957496643},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3718714714050293},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.34775015711784363},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3359605371952057},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.18550199270248413},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17315667867660522},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11971679329872131},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.0973757803440094}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6013215184211731},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5645946264266968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5560243129730225},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5498487949371338},{"id":"https://openalex.org/C2779030066","wikidata":"https://www.wikidata.org/wiki/Q1137767","display_name":"Muscular dystrophy","level":2,"score":0.5328795313835144},{"id":"https://openalex.org/C2778943923","wikidata":"https://www.wikidata.org/wiki/Q1648484","display_name":"Duchenne muscular dystrophy","level":2,"score":0.5226873159408569},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5045033693313599},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.48857054114341736},{"id":"https://openalex.org/C70437156","wikidata":"https://www.wikidata.org/wiki/Q7228652","display_name":"Pooling","level":2,"score":0.45865389704704285},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37545353174209595},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3736467957496643},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3718714714050293},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34775015711784363},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3359605371952057},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.18550199270248413},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17315667867660522},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11971679329872131},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0973757803440094},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3584371.3613066","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3584371.3613066","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3584371.3613066","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1145/3584371.3613066","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3584371.3613066","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3584371.3613066","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8100000023841858}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334601","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387346431.pdf","grobid_xml":"https://content.openalex.org/works/W4387346431.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2953234277","https://openalex.org/W2626256601","https://openalex.org/W147410782","https://openalex.org/W2900413183","https://openalex.org/W4390975304","https://openalex.org/W3022252430","https://openalex.org/W4287804464","https://openalex.org/W3103989898","https://openalex.org/W3211292372","https://openalex.org/W803346624"],"abstract_inverted_index":{"Muscle":[0],"stem":[1,35,53,96],"cells":[2,8,79],"(MuSCs),":[3],"also":[4],"commonly":[5],"called":[6],"satellite":[7],"(SCs),":[9],"work":[10],"to":[11,69,80,103,112,156],"repair":[12],"damaged":[13,110],"muscle":[14,23,143],"after":[15],"injury":[16,163],"and":[17,84,91,165,179],"are":[18],"key":[19],"targets":[20],"for":[21],"treating":[22],"diseases":[24],"such":[25],"as":[26,42,58,60,148],"Duchenne's":[27],"Muscular":[28],"Dystrophy":[29],"(DMD).":[30],"However,":[31,132],"clinical":[32],"application":[33],"of":[34,49,107,124,137],"cell":[36,54,71,97,139,171,183],"therapy":[37],"has":[38],"run":[39],"into":[40],"challenges":[41],"it":[43],"is":[44,66],"hampered":[45],"by":[46],"the":[47,70,85,95,105,122,135,187],"complexity":[48],"manipulating":[50],"or":[51,109],"augmenting":[52],"systems":[55],"in":[56,160],"vivo":[57],"well":[59],"their":[61],"diverse":[62],"differentiation":[63],"pathways.":[64],"This":[65],"partially":[67],"due":[68,155],"heterogeneity,":[72],"dynamic":[73,86],"gene":[74],"regulatory":[75],"mechanisms":[76,90],"that":[77],"drive":[78],"make":[81],"fate":[82],"decisions,":[83],"interplay":[87],"between":[88],"intrinsic":[89],"extrinsic":[92],"factors":[93],"constituting":[94],"niche.":[98],"Previous":[99],"models":[100],"have":[101,118],"attempted":[102],"simulate":[104],"response":[106],"healthy":[108],"tissue":[111],"continual":[113],"injury-induced":[114],"damage.":[115],"These":[116],"studies":[117],"often":[119],"relied":[120],"on":[121,128,182],"analysis":[123],"multiple":[125,197],"experiments":[126],"conducted":[127],"injured":[129],"skeletal":[130],"muscles.":[131],"accurately":[133],"capturing":[134],"influx":[136],"each":[138],"within":[140,186],"a":[141,145],"single":[142,170],"poses":[144],"significant":[146],"challenge":[147],"variable":[149],"sources":[150],"may":[151],"present":[152],"potential":[153],"biases":[154,191],"inter-experiment":[157],"variability,":[158],"differences":[159],"sample":[161],"collection,":[162],"protocols,":[164],"technical":[166],"variations.":[167],"By":[168],"leveraging":[169],"RNA":[172],"sequencing":[173],"(scRNA-seq)":[174],"data,":[175],"we":[176],"obtain":[177],"comprehensive":[178],"unbiased":[180],"information":[181],"type":[184],"proportions":[185],"same":[188],"muscle,":[189],"avoiding":[190],"associated":[192],"with":[193],"pooling":[194],"data":[195],"from":[196],"sources.":[198]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
