{"id":"https://openalex.org/W4387346468","doi":"https://doi.org/10.1145/3584371.3613029","title":"Automated Focus Restoration for High-throughput Phase Contrast Time-lapse Microscopy with De-noising Diffusion Probabilistic Model","display_name":"Automated Focus Restoration for High-throughput Phase Contrast Time-lapse Microscopy with De-noising Diffusion Probabilistic Model","publication_year":2023,"publication_date":"2023-09-03","ids":{"openalex":"https://openalex.org/W4387346468","doi":"https://doi.org/10.1145/3584371.3613029"},"language":"en","primary_location":{"id":"doi:10.1145/3584371.3613029","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3584371.3613029","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3584371.3613029","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dl.acm.org/doi/pdf/10.1145/3584371.3613029","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091682697","display_name":"Kwan-Ling Wu","orcid":"https://orcid.org/0009-0007-7889-6539"},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kwan-Ling Wu","raw_affiliation_strings":["University of Houston, Houston, USA"],"raw_orcid":"https://orcid.org/0009-0007-7889-6539","affiliations":[{"raw_affiliation_string":"University of Houston, Houston, USA","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029150146","display_name":"Melisa J. Montalvo","orcid":"https://orcid.org/0009-0008-9395-6998"},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melisa Montalvo","raw_affiliation_strings":["University of Houston, Houston, USA"],"raw_orcid":"https://orcid.org/0009-0008-9395-6998","affiliations":[{"raw_affiliation_string":"University of Houston, Houston, USA","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040327327","display_name":"Prashant S. Menon","orcid":"https://orcid.org/0000-0001-6415-5202"},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prashant Menon","raw_affiliation_strings":["University of Houston, Houston, USA"],"raw_orcid":"https://orcid.org/0000-0001-6415-5202","affiliations":[{"raw_affiliation_string":"University of Houston, Houston, USA","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090480130","display_name":"Badrinath Roysam","orcid":"https://orcid.org/0000-0002-8310-1389"},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Badrinath Roysam","raw_affiliation_strings":["University of Houston, Houston, USA"],"raw_orcid":"https://orcid.org/0000-0002-8310-1389","affiliations":[{"raw_affiliation_string":"University of Houston, Houston, USA","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041553722","display_name":"Navin Varadarajan","orcid":"https://orcid.org/0000-0001-7524-8228"},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navin Varadarajan","raw_affiliation_strings":["University of Houston, Houston, USA"],"raw_orcid":"https://orcid.org/0000-0001-7524-8228","affiliations":[{"raw_affiliation_string":"University of Houston, Houston, USA","institution_ids":["https://openalex.org/I44461941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5091682697"],"corresponding_institution_ids":["https://openalex.org/I44461941"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18274056,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11897","display_name":"Digital Holography and Microscopy","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phase-contrast-microscopy","display_name":"Phase contrast microscopy","score":0.6636248826980591},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6168005466461182},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.5912192463874817},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5579784512519836},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.49404314160346985},{"id":"https://openalex.org/keywords/usable","display_name":"USable","score":0.4622376561164856},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.452802449464798},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.43490681052207947},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3616265058517456},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.3361050486564636},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.16710516810417175},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.15508833527565002},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13558140397071838},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.11528605222702026}],"concepts":[{"id":"https://openalex.org/C151193507","wikidata":"https://www.wikidata.org/wiki/Q898815","display_name":"Phase contrast microscopy","level":2,"score":0.6636248826980591},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6168005466461182},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.5912192463874817},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5579784512519836},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.49404314160346985},{"id":"https://openalex.org/C2780615836","wikidata":"https://www.wikidata.org/wiki/Q2471869","display_name":"USable","level":2,"score":0.4622376561164856},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.452802449464798},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.43490681052207947},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3616265058517456},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3361050486564636},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16710516810417175},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.15508833527565002},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13558140397071838},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11528605222702026},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3584371.3613029","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3584371.3613029","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3584371.3613029","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1145/3584371.3613029","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3584371.3613029","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3584371.3613029","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.6299999952316284,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387346468.pdf","grobid_xml":"https://content.openalex.org/works/W4387346468.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2982321410","https://openalex.org/W2392004567","https://openalex.org/W2182798531","https://openalex.org/W1500767623","https://openalex.org/W4205840878","https://openalex.org/W2133926606","https://openalex.org/W2032360819","https://openalex.org/W2056231686","https://openalex.org/W604201051","https://openalex.org/W2184218576"],"abstract_inverted_index":{"Cell-based":[0],"immunotherapies":[1],"have":[2],"revolutionized":[3],"cancer":[4],"treatment":[5],"with":[6],"unprecedented":[7],"efficacy":[8],"against":[9],"leukemias":[10],"and":[11,32,38,49,61,98,108],"lymphomas.":[12],"High-throughput":[13],"(HT)":[14],"time-lapse":[15],"imaging":[16],"serves":[17],"as":[18,29],"a":[19],"fundamental":[20],"technology":[21],"to":[22,33,41,79],"enable":[23],"the":[24,57,66,80,96],"profiling":[25,51],"of":[26,70,83,90,100,110],"immune":[27,84],"cells":[28,75,85,92],"anti-cancer":[30],"drugs":[31],"help":[34],"map":[35],"their":[36],"complexity":[37],"heterogeneity.":[39],"Migrating":[40],"label-free":[42],"phase-contrast":[43],"video":[44],"microscopy":[45],"promises":[46],"non-invasive,":[47],"non-toxic,":[48],"efficient":[50],"at":[52],"single-cell":[53],"level":[54],"resolution.":[55],"Balancing":[56],"tradeoffs":[58],"between":[59],"speed":[60],"throughput":[62],"implies":[63],"that":[64],"despite":[65],"best":[67],"autofocusing":[68],"algorithms":[69],"HT":[71],"systems,":[72],"out-of-focus":[73],"(OOF)":[74],"are":[76],"unavoidable":[77],"due":[78],"migratory":[81],"nature":[82],"(velocities":[86],">10":[87],"\u03bcm/min).":[88],"Restoration":[89],"OOF":[91],"after":[93],"acquisition":[94],"increases":[95],"yield":[97],"accuracy":[99],"usable":[101],"data":[102],"by":[103],"allowing":[104],"more":[105],"accurate":[106],"segmentation":[107],"delineation":[109],"cell-cell":[111],"contact.":[112]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}