{"id":"https://openalex.org/W4327520726","doi":"https://doi.org/10.1145/3574198.3574228","title":"Reward Coding of Hippocampal Neurons in Goal-directed Spatial Memory","display_name":"Reward Coding of Hippocampal Neurons in Goal-directed Spatial Memory","publication_year":2022,"publication_date":"2022-11-10","ids":{"openalex":"https://openalex.org/W4327520726","doi":"https://doi.org/10.1145/3574198.3574228"},"language":"en","primary_location":{"id":"doi:10.1145/3574198.3574228","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3574198.3574228","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2022 9th International Conference on Biomedical and Bioinformatics Engineering","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049388925","display_name":"Shuang Meng","orcid":null},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuang Meng","raw_affiliation_strings":["College of Precision Instruments & Optoelectronics Engineering, Tianjin University, China"],"raw_orcid":"https://orcid.org/0000-0001-9616-8753","affiliations":[{"raw_affiliation_string":"College of Precision Instruments & Optoelectronics Engineering, Tianjin University, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051190861","display_name":"Yimeng Wang","orcid":"https://orcid.org/0000-0002-1489-8320"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yimeng Wang","raw_affiliation_strings":["Academy of Medical Engineering and Translational Medicine, Tianjin University, China"],"raw_orcid":"https://orcid.org/0000-0002-1489-8320","affiliations":[{"raw_affiliation_string":"Academy of Medical Engineering and Translational Medicine, Tianjin University, China","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081587154","display_name":"Ling Wang","orcid":"https://orcid.org/0000-0002-2532-6467"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Wang","raw_affiliation_strings":["College of Precision Instruments & Optoelectronics Engineering, Tianjin University, China and \rAcademy of Medical Engineering and Translational Medicine, Tianjin University, China"],"raw_orcid":"https://orcid.org/0000-0002-2532-6467","affiliations":[{"raw_affiliation_string":"College of Precision Instruments & Optoelectronics Engineering, Tianjin University, China and \rAcademy of Medical Engineering and Translational Medicine, Tianjin University, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068826437","display_name":"Jiajia Yang","orcid":"https://orcid.org/0000-0001-5439-7136"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Yang","raw_affiliation_strings":["College of Precision Instruments & Optoelectronics Engineering, Tianjin University, China and \rAcademy of Medical Engineering and Translational Medicine, Tianjin University, China"],"raw_orcid":"https://orcid.org/0000-0001-5439-7136","affiliations":[{"raw_affiliation_string":"College of Precision Instruments & Optoelectronics Engineering, Tianjin University, China and \rAcademy of Medical Engineering and Translational Medicine, Tianjin University, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002715805","display_name":"Chenguang Zheng","orcid":"https://orcid.org/0000-0002-4782-8732"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenguang Zheng","raw_affiliation_strings":["College of Precision Instruments & Optoelectronics Engineering, Tianjin University, China and \rAcademy of Medical Engineering and Translational Medicine, Tianjin University, China"],"raw_orcid":"https://orcid.org/0000-0002-4782-8732","affiliations":[{"raw_affiliation_string":"College of Precision Instruments & Optoelectronics Engineering, Tianjin University, China and \rAcademy of Medical Engineering and Translational Medicine, Tianjin University, China","institution_ids":["https://openalex.org/I162868743"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5049388925"],"corresponding_institution_ids":["https://openalex.org/I162868743"],"apc_list":null,"apc_paid":null,"fwci":0.2355,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.52478043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"190","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9908000230789185,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.6407429575920105},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6122311353683472},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5630384683609009},{"id":"https://openalex.org/keywords/place-cell","display_name":"Place cell","score":0.5607657432556152},{"id":"https://openalex.org/keywords/coding","display_name":"Coding (social sciences)","score":0.5119420289993286},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"Spatial memory","score":0.5056307315826416},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.49945688247680664},{"id":"https://openalex.org/keywords/encoding","display_name":"Encoding (memory)","score":0.4952773153781891},{"id":"https://openalex.org/keywords/spatial-contextual-awareness","display_name":"Spatial contextual awareness","score":0.4299084544181824},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.4259708523750305},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.32002511620521545},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27741333842277527},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22366675734519958},{"id":"https://openalex.org/keywords/working-memory","display_name":"Working memory","score":0.19271349906921387},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.1393151879310608},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.0729268491268158}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6407429575920105},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6122311353683472},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5630384683609009},{"id":"https://openalex.org/C2781369091","wikidata":"https://www.wikidata.org/wiki/Q2303730","display_name":"Place cell","level":3,"score":0.5607657432556152},{"id":"https://openalex.org/C179518139","wikidata":"https://www.wikidata.org/wiki/Q5140297","display_name":"Coding (social sciences)","level":2,"score":0.5119420289993286},{"id":"https://openalex.org/C43729271","wikidata":"https://www.wikidata.org/wiki/Q3560550","display_name":"Spatial memory","level":4,"score":0.5056307315826416},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.49945688247680664},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.4952773153781891},{"id":"https://openalex.org/C64754055","wikidata":"https://www.wikidata.org/wiki/Q7574053","display_name":"Spatial contextual awareness","level":2,"score":0.4299084544181824},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4259708523750305},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32002511620521545},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27741333842277527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22366675734519958},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.19271349906921387},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1393151879310608},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0729268491268158},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3574198.3574228","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3574198.3574228","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2022 9th International Conference on Biomedical and Bioinformatics Engineering","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.4099999964237213,"id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G4259212904","display_name":null,"funder_award_id":"81870847, 82271218, 31800889, 81871517, 82202797","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2087298647","https://openalex.org/W2264119724","https://openalex.org/W2581980900","https://openalex.org/W2751994341","https://openalex.org/W2811470308","https://openalex.org/W2902271113","https://openalex.org/W2953342065","https://openalex.org/W3002023792","https://openalex.org/W3014897911","https://openalex.org/W3041437212","https://openalex.org/W3132482678"],"related_works":["https://openalex.org/W3006011994","https://openalex.org/W3043853885","https://openalex.org/W2096876955","https://openalex.org/W4309949331","https://openalex.org/W2170688882","https://openalex.org/W3022988025","https://openalex.org/W1993176282","https://openalex.org/W2108836624","https://openalex.org/W4365815800","https://openalex.org/W4307527434"],"abstract_inverted_index":{"The":[0,81,127],"hippocampus":[1],"plays":[2],"a":[3,45,66,178],"key":[4],"role":[5],"in":[6,35,124,146,152,190],"goal-directed":[7],"navigation,":[8],"as":[9,39,95],"most":[10],"excitatory":[11],"neurons":[12,86,119],"are":[13,20,41],"called":[14],"place":[15,103],"cells":[16,104,167],"whose":[17],"firing":[18,122],"patterns":[19,123],"strongly":[21],"correlated":[22],"to":[23,75,150,170],"specific":[24],"spatial":[25,69,125,140],"locations.":[26],"In":[27],"addition,":[28],"locations":[29,79,164],"associated":[30],"with":[31],"other":[32],"salient":[33],"features":[34],"the":[36,51,85,89,98,102,106,135,159,184,191],"context,":[37],"such":[38],"rewards,":[40],"also":[42],"represented":[43],"by":[44,138,165],"subset":[46],"of":[47,118,162,187],"hippocampal":[48],"neurons.":[49],"However,":[50],"cellular":[52],"coding":[53,144],"mechanism":[54],"underlying":[55],"this":[56,62],"representation":[57,161],"remains":[58],"elusive.":[59],"To":[60],"address":[61],"question,":[63],"we":[64],"designed":[65],"delayed":[67],"match-to-sample":[68],"memory":[70,172],"task":[71],"which":[72],"requires":[73],"rats":[74],"learn":[76],"two":[77,96,116],"goal":[78,136,163],"individually.":[80],"results":[82],"showed":[83],"that":[84,87,114,151,158],"overexpressed":[88],"reward":[90,99,107,128,166,188],"location":[91,108,137],"could":[92],"be":[93],"classified":[94],"types:":[97],"cells,":[100,129,133],"and":[101,142],"representing":[105],"(stable":[109],"cells).":[110],"We":[111],"further":[112,182],"found":[113],"these":[115],"types":[117],"exhibited":[120],"different":[121],"memory.":[126],"but":[130],"not":[131],"stable":[132],"encoded":[134],"high":[139],"specificity":[141],"accurate":[143],"mode":[145],"correct":[147],"trials":[148],"compared":[149],"error":[153],"trials.":[154],"These":[155],"findings":[156],"suggest":[157],"precise":[160],"prominently":[168],"contributes":[169],"successful":[171],"retrieval.":[173],"Our":[174],"study":[175],"may":[176],"provide":[177],"new":[179],"direction":[180],"for":[181],"understanding":[183],"internal":[185],"mechanisms":[186],"encoding":[189],"brain.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}