{"id":"https://openalex.org/W4312240746","doi":"https://doi.org/10.1145/3570773.3570854","title":"Targeted Nanoparticle Carriers Loaded with ICG for Photodynamic Therapy","display_name":"Targeted Nanoparticle Carriers Loaded with ICG for Photodynamic Therapy","publication_year":2022,"publication_date":"2022-10-13","ids":{"openalex":"https://openalex.org/W4312240746","doi":"https://doi.org/10.1145/3570773.3570854"},"language":"en","primary_location":{"id":"doi:10.1145/3570773.3570854","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3570773.3570854","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 3rd International Symposium on Artificial Intelligence for Medicine Sciences","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085649443","display_name":"Wenjie Chao","orcid":"https://orcid.org/0000-0001-9076-3818"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenjie Chao","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Xiamen University, China"],"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Xiamen University, China","institution_ids":["https://openalex.org/I191208505"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085649443"],"corresponding_institution_ids":["https://openalex.org/I191208505"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12213581,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"404","last_page":"408"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"Photodynamic therapy","score":0.954657256603241},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"Reactive oxygen species","score":0.6841121315956116},{"id":"https://openalex.org/keywords/photosensitizer","display_name":"Photosensitizer","score":0.6645768880844116},{"id":"https://openalex.org/keywords/singlet-oxygen","display_name":"Singlet oxygen","score":0.6564662456512451},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"Cytotoxicity","score":0.564582884311676},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5563616752624512},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4303259551525116},{"id":"https://openalex.org/keywords/indocyanine-green","display_name":"Indocyanine green","score":0.4269621968269348},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4174317419528961},{"id":"https://openalex.org/keywords/photochemistry","display_name":"Photochemistry","score":0.36514604091644287},{"id":"https://openalex.org/keywords/oxygen","display_name":"Oxygen","score":0.3482300937175751},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.33580952882766724},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.22498878836631775},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.15824520587921143},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14263784885406494},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.111101895570755},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09802466630935669}],"concepts":[{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.954657256603241},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6841121315956116},{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.6645768880844116},{"id":"https://openalex.org/C2777516457","wikidata":"https://www.wikidata.org/wiki/Q2413613","display_name":"Singlet oxygen","level":3,"score":0.6564662456512451},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.564582884311676},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5563616752624512},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4303259551525116},{"id":"https://openalex.org/C2781065829","wikidata":"https://www.wikidata.org/wiki/Q905662","display_name":"Indocyanine green","level":2,"score":0.4269621968269348},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4174317419528961},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.36514604091644287},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.3482300937175751},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33580952882766724},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22498878836631775},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15824520587921143},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14263784885406494},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.111101895570755},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09802466630935669},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3570773.3570854","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3570773.3570854","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 3rd International Symposium on Artificial Intelligence for Medicine Sciences","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.4099999964237213}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1596848781","https://openalex.org/W2054432852","https://openalex.org/W2097233311","https://openalex.org/W2145645129","https://openalex.org/W2151734986","https://openalex.org/W2321849209","https://openalex.org/W2327945602","https://openalex.org/W2605138217","https://openalex.org/W4210632008"],"related_works":["https://openalex.org/W4247044552","https://openalex.org/W4234956294","https://openalex.org/W2065286408","https://openalex.org/W2753164976","https://openalex.org/W2897712569","https://openalex.org/W2256492013","https://openalex.org/W3029655042","https://openalex.org/W2158428798","https://openalex.org/W2361848027","https://openalex.org/W1993133184"],"abstract_inverted_index":{"Photodynamic":[0],"therapy":[1],"(PDT)":[2],"is":[3,22,56,80,141,159],"a":[4,27,81,91,112,163],"clinically":[5],"approved,":[6],"minimally":[7],"invasive":[8],"treatment":[9],"that":[10,83],"can":[11],"exert":[12],"selective":[13],"cytotoxic":[14],"activity":[15],"against":[16],"malignant":[17],"cells.":[18,138],"When":[19,43],"the":[20,33,40,47,97,119,129,134],"photosensitizer":[21],"exposed":[23],"to":[24,39,46,60,87,114,121,124,143,154,161],"light":[25,36],"of":[26,35,99,128,136],"specific":[28,126],"wavelength,":[29],"its":[30],"electrons":[31],"absorb":[32],"energy":[34,55],"and":[37,64,157],"transition":[38],"excited":[41],"state.":[42],"it":[44,50,95,158],"returns":[45],"ground":[48],"state,":[49],"releases":[51],"energy.":[52],"The":[53,139],"released":[54],"absorbed":[57],"by":[58],"oxygen":[59,63,71],"form":[61],"singlet":[62],"free":[65],"radicals,":[66],"also":[67],"known":[68],"as":[69,90,111],"reactive":[70],"species":[72],"(ROS).":[73],"These":[74],"ROS":[75],"produce":[76],"cytotoxicity.":[77],"Indocyanine":[78],"green":[79],"drug":[82,120,140],"has":[84,96],"been":[85],"reported":[86],"be":[88,162],"useful":[89],"photodynamic":[92,167],"therapy,":[93],"but":[94],"problem":[98],"easy":[100],"decomposition":[101],"in":[102],"combination":[103],"with":[104,151],"hemoglobin,":[105],"therefore,":[106],"this":[107],"paper":[108],"uses":[109],"PFOB":[110],"carrier":[113],"transport":[115],"drugs":[116],"while":[117],"coupling":[118],"hyaluronic":[122],"acid,":[123],"achieve":[125,144],"recognition":[127],"CD-44":[130],"molecular":[131],"receptor":[132],"on":[133,148],"surface":[135],"tumor":[137,149],"expected":[142,160],"better":[145],"killing":[146],"effect":[147],"cells":[150],"little":[152],"toxicity":[153],"other":[155],"cells,":[156],"favorable":[164],"candidate":[165],"for":[166],"therapy.":[168]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}