{"id":"https://openalex.org/W4312380358","doi":"https://doi.org/10.1145/3570773.3570800","title":"Mutating PD-1 to Avoid PD-L1 From Binding Therefore Regulates NSCLC","display_name":"Mutating PD-1 to Avoid PD-L1 From Binding Therefore Regulates NSCLC","publication_year":2022,"publication_date":"2022-10-13","ids":{"openalex":"https://openalex.org/W4312380358","doi":"https://doi.org/10.1145/3570773.3570800"},"language":"en","primary_location":{"id":"doi:10.1145/3570773.3570800","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3570773.3570800","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 3rd International Symposium on Artificial Intelligence for Medicine Sciences","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039209027","display_name":"Yihansheng Chen","orcid":"https://orcid.org/0000-0002-0736-5200"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yihansheng Chen","raw_affiliation_strings":["University of California Santa Barbara, United States"],"affiliations":[{"raw_affiliation_string":"University of California Santa Barbara, United States","institution_ids":["https://openalex.org/I154570441"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039209027"],"corresponding_institution_ids":["https://openalex.org/I154570441"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26229272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"52","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.5318357944488525},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4472084939479828},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3505169153213501},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.34546834230422974},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19759470224380493},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1570391058921814},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.149091899394989},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.11189436912536621}],"concepts":[{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.5318357944488525},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4472084939479828},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3505169153213501},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34546834230422974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19759470224380493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1570391058921814},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.149091899394989},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.11189436912536621}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3570773.3570800","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3570773.3570800","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 3rd International Symposium on Artificial Intelligence for Medicine Sciences","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8399999737739563}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2047502920","https://openalex.org/W2743614427","https://openalex.org/W3043942728","https://openalex.org/W3082106558","https://openalex.org/W3170003796","https://openalex.org/W6775391015"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487","https://openalex.org/W1986764834"],"abstract_inverted_index":{"Lung":[0],"cancer":[1,10],"is":[2,161,167,196],"one":[3],"of":[4,9,23,87,137,176,187,201,207,215],"the":[5,33,57,66,80,85,104,115,135,138,142,184,198,205,208,213],"most":[6],"common":[7],"types":[8],"in":[11,65,103,108,141],"human":[12],"clinical":[13],"cases.":[14],"It":[15],"has":[16],"been":[17],"a":[18],"worldwide":[19],"problem":[20],"for":[21,152,183],"hundreds":[22],"years.":[24],"Currently,":[25],"there":[26,44],"are":[27,45],"more":[28,126],"research":[29,186],"done":[30],"on":[31,92,197],"blocking":[32],"pathway":[34,58],"between":[35],"PD-1":[36,67,188,202,216],"and":[37,68,112,121,149,210,217],"PD-L1":[38,69],"using":[39,72,150],"drugs":[40],"or":[41],"antibodies;":[42],"however,":[43],"not":[46],"that":[47,50,195],"many":[48],"papers":[49],"write":[51],"about":[52],"other":[53],"ways":[54],"to":[55,74,97,156],"block":[56],"such":[59],"as":[60],"knocking":[61],"down":[62],"ASN":[63],"45":[64],"binding":[70,106,199],"domain":[71,107,200],"CRISPR":[73,96],"change":[75,204],"PD-1\u2019s":[76],"structure,":[77],"therefore,":[78],"regulating":[79],"binding.":[81],"This":[82],"study":[83,178],"investigates":[84],"effect":[86],"genetic":[88],"engineered":[89],"T":[90,110],"cells":[91,111,116,140,224],"NSCLC":[93,118],"xenograft":[94,119],"mice.":[95],"mutate":[98],"PD1":[99,130],"amino":[100,193],"acids(ASN":[101],"45)":[102],"PDL1":[105],"effector":[109],"then":[113,221],"inject":[114],"into":[117],"mice":[120],"see":[122],"if":[123],"tumor":[124,143],"shrinks":[125],"than":[127],"Wild":[128,162,171],"Type":[129,163,172],"control":[131,160,166],"injections.":[132],"Also":[133],"measure":[134],"activation":[136],"t":[139],"by":[144,147],"isolating":[145],"them":[146],"FACS":[148,151],"CD69,":[153],"pSrc,":[154],"pErk":[155],"detect":[157],"activation.":[158],"Negative":[159],"PD1,":[164],"positive":[165],"Keytruda":[168],"treatments":[169],"with":[170],"PD1.":[173],"The":[174],"result":[175],"this":[177],"will":[179],"provide":[180],"essential":[181],"information":[182],"future":[185],"mutation.":[189],"By":[190],"mutating":[191],"certain":[192],"acid":[194],"would":[203,220],"structure":[206],"glycoprotein":[209],"therefore":[211],"avoid":[212],"combination":[214],"PD-L1,":[218],"which":[219],"forbid":[222],"cancerous":[223],"from":[225],"evading":[226],"immune":[227],"detection.":[228]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
