{"id":"https://openalex.org/W4290671768","doi":"https://doi.org/10.1145/3543377.3543395","title":"Effect of PSPH on Angiogenesis and Migration of Hepatocellular Carcinoma Cells","display_name":"Effect of PSPH on Angiogenesis and Migration of Hepatocellular Carcinoma Cells","publication_year":2022,"publication_date":"2022-05-27","ids":{"openalex":"https://openalex.org/W4290671768","doi":"https://doi.org/10.1145/3543377.3543395"},"language":"en","primary_location":{"id":"doi:10.1145/3543377.3543395","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3543377.3543395","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 14th International Conference on Bioinformatics and Biomedical Technology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054312166","display_name":"Hang Min","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hang Min","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058766870","display_name":"Hao Zhou","orcid":"https://orcid.org/0000-0003-1635-1764"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Zhou","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106430337","display_name":"Duo Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Duo Zheng","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101899889","display_name":"Yang Deng","orcid":"https://orcid.org/0009-0006-0825-9596"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Deng","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068811844","display_name":"Fujian Wan","orcid":"https://orcid.org/0000-0002-1140-5367"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fujian Wan","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101705557","display_name":"Shijie Ding","orcid":"https://orcid.org/0000-0001-8878-2497"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijie Ding","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100988745","display_name":"Jingjiao Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjiao Zhou","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002561193","display_name":"Jun Zhou","orcid":"https://orcid.org/0000-0003-1714-4011"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Zhou","raw_affiliation_strings":["College of Life Sciences and Health, Wuhan University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Health, Wuhan University of Science and Technology, China","institution_ids":["https://openalex.org/I43922553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5054312166"],"corresponding_institution_ids":["https://openalex.org/I43922553"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1152791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"120","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9445000290870667,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9445000290870667,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9283000230789185,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.777977466583252},{"id":"https://openalex.org/keywords/cell-migration","display_name":"Cell migration","score":0.5032259821891785},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.4966588616371155},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.48899662494659424},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"Gene knockdown","score":0.48189765214920044},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.41082483530044556},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3793601989746094},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3247406482696533},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09236186742782593}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.777977466583252},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.5032259821891785},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.4966588616371155},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48899662494659424},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.48189765214920044},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41082483530044556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3793601989746094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3247406482696533},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09236186742782593}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3543377.3543395","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3543377.3543395","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 14th International Conference on Bioinformatics and Biomedical Technology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4386799875","https://openalex.org/W4213065871","https://openalex.org/W4361818220","https://openalex.org/W4361818978","https://openalex.org/W4361818627","https://openalex.org/W3157667906","https://openalex.org/W2800322456","https://openalex.org/W2075734225","https://openalex.org/W2931234257","https://openalex.org/W3189609572"],"abstract_inverted_index":{"PSPH":[0,19,37,61,66,92,106,121],"expression":[1,35,47,90],"is":[2],"imbalanced":[3],"in":[4,12,38,56,84,94],"many":[5],"organs":[6],"and":[7,22,28,33,50,69,80,97,110],"tissues,":[8],"with":[9,60,100],"high":[10],"level":[11],"liver.":[13],"To":[14],"investigate":[15],"the":[16,89,108,118],"effect":[17,64],"of":[18,24,36,48,65,71,91,112,120,126],"on":[20,67],"angiogenesis":[21,51,70,111],"migration":[23,49,68,109],"hepatocellular":[25,113],"carcinoma":[26,114],"(HCC)":[27],"its":[29],"potential":[30,119],"mechanism,":[31],"mRNA":[32],"protein":[34,46],"human":[39],"hepatocarcinoma":[40,57],"cell":[41,58,103],"lines":[42,59],"were":[43,54],"investigated.":[44],"The":[45,63],"related":[52],"proteins":[53],"investigated":[55,74],"knockdown.":[62],"SMMC-7721":[72],"was":[73],"by":[75],"transwell,":[76],"wound":[77],"healing":[78],"assay":[79,83],"tube":[81],"formation":[82],"vitro.":[85],"Results":[86],"showed":[87],"that":[88],"increased":[93],"SMMC-7721,":[95],"HepG2":[96],"Huh7,":[98],"compared":[99],"normal":[101],"liver":[102],"LO2.":[104],"And":[105],"promoted":[107],"cells.":[115],"it":[116],"suggests":[117],"as":[122],"a":[123],"diagnostic":[124],"indicator":[125],"HCC.":[127]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
