{"id":"https://openalex.org/W4290671618","doi":"https://doi.org/10.1145/3543377.3543391","title":"Pan-cancer analysis of CDCA2 and its function in papillary renal cell carcinoma","display_name":"Pan-cancer analysis of CDCA2 and its function in papillary renal cell carcinoma","publication_year":2022,"publication_date":"2022-05-27","ids":{"openalex":"https://openalex.org/W4290671618","doi":"https://doi.org/10.1145/3543377.3543391"},"language":"en","primary_location":{"id":"doi:10.1145/3543377.3543391","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3543377.3543391","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 14th International Conference on Bioinformatics and Biomedical Technology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101849757","display_name":"Fang Li","orcid":"https://orcid.org/0000-0003-4211-5087"},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fang Li","raw_affiliation_strings":["School of Basic Medical Sciences, Xi'an Jiaotong University, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Xi'an Jiaotong University, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101913024","display_name":"Qiuyu Jiang","orcid":"https://orcid.org/0000-0003-4461-2829"},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiuyu Jiang","raw_affiliation_strings":["School of Basic Medical Sciences, Xi'an Jiaotong University, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Xi'an Jiaotong University, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100677997","display_name":"Jinyuan Zhang","orcid":"https://orcid.org/0000-0003-0524-201X"},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinyuan Zhang","raw_affiliation_strings":["School of Basic Medical Sciences, Xi'an Jiaotong University, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Xi'an Jiaotong University, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104085299","display_name":"Xintao Jing","orcid":"https://orcid.org/0000-0001-9080-4421"},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xintao Jing","raw_affiliation_strings":["School of Basic Medical Sciences, Xi'an Jiaotong University, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Xi'an Jiaotong University, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055627623","display_name":"Xiaofei Wang","orcid":"https://orcid.org/0000-0002-7704-4445"},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofei Wang","raw_affiliation_strings":["Biomedical Experimental Center, Xi'an Jiaotong University, China"],"affiliations":[{"raw_affiliation_string":"Biomedical Experimental Center, Xi'an Jiaotong University, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102854441","display_name":"Chen-Tsung Huang","orcid":"https://orcid.org/0000-0003-4187-2967"},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Huang","raw_affiliation_strings":["School of Basic Medical Sciences, Xi'an Jiaotong University, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Xi'an Jiaotong University, China","institution_ids":["https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5101849757"],"corresponding_institution_ids":["https://openalex.org/I87445476"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16661203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"94","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9624999761581421,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papillary-renal-cell-carcinomas","display_name":"Papillary renal cell carcinomas","score":0.600699245929718},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"Kidney cancer","score":0.5490739941596985},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"Renal cell carcinoma","score":0.5183845162391663},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.5183449983596802},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.45827412605285645},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.4214753210544586},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4180545508861542},{"id":"https://openalex.org/keywords/carcinoma","display_name":"Carcinoma","score":0.4137468636035919},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3910123407840729},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3612091839313507},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.35765406489372253}],"concepts":[{"id":"https://openalex.org/C2776531350","wikidata":"https://www.wikidata.org/wiki/Q16877679","display_name":"Papillary renal cell carcinomas","level":3,"score":0.600699245929718},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.5490739941596985},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.5183845162391663},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5183449983596802},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45827412605285645},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.4214753210544586},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4180545508861542},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4137468636035919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3910123407840729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3612091839313507},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35765406489372253}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3543377.3543391","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3543377.3543391","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 14th International Conference on Bioinformatics and Biomedical Technology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1970097556","https://openalex.org/W2002587870","https://openalex.org/W2008903601","https://openalex.org/W2034269086","https://openalex.org/W2082331198","https://openalex.org/W2094526575","https://openalex.org/W2097805947","https://openalex.org/W2130430382","https://openalex.org/W2133803651","https://openalex.org/W2499333227","https://openalex.org/W2765224588","https://openalex.org/W2902704467","https://openalex.org/W2949469310","https://openalex.org/W3002949543","https://openalex.org/W3008479505","https://openalex.org/W3027658366","https://openalex.org/W3041242548","https://openalex.org/W3046356442","https://openalex.org/W3133001353","https://openalex.org/W3168722561","https://openalex.org/W3204105165","https://openalex.org/W4292166992"],"related_works":["https://openalex.org/W4212773757","https://openalex.org/W2126021534","https://openalex.org/W4317042786","https://openalex.org/W3214746322","https://openalex.org/W1978873562","https://openalex.org/W2890733234","https://openalex.org/W2586712077","https://openalex.org/W4200538675","https://openalex.org/W4200464512","https://openalex.org/W4200590592"],"abstract_inverted_index":{"Papillary":[0],"renal":[1,93],"cell":[2,13,44,95],"carcinoma":[3,14,90,96,101],"(PRCC)":[4],"is":[5,172],"the":[6,54,61,66,86,106,146,154,188],"second":[7],"most":[8],"common":[9],"type":[10],"of":[11,56,72,88,148,156,159],"Renal":[12],"(RCC)":[15],"with":[16,35,128],"insidious":[17],"early":[18],"symptoms":[19],"and":[20,53,68,78,98,111,124,131,183,202],"low":[21],"clinical":[22,69,129],"detection":[23],"rate.":[24],"Studies":[25],"have":[26,41],"reported":[27],"that":[28,80,117,145,170,192],"higher":[29],"CDCA2":[30,57,73,81,118,149,171,193],"expression":[31,50,67,119,147],"levels":[32],"are":[33],"associated":[34,127],"several":[36],"cancers,":[37],"but":[38],"no":[39],"studies":[40],"comprehensively":[42],"analyzed":[43,65],"division":[45],"cycle-associated":[46],"protein":[47],"2":[48],"(CDCA2)":[49],"in":[51,58,74,85,122,175],"pan-cancer":[52,75],"role":[55],"PRCC.":[59,160,211],"In":[60,161,186],"present":[62,189],"study,":[63],"we":[64],"prognostic":[70],"value":[71],"including":[76],"PRCC":[77,103,123,201],"find":[79],"was":[82,120,125,150],"mainly":[83,173],"involved":[84,174],"progression":[87],"Adrenocortical":[89],"(ACC),":[91],"Kidney":[92],"papillary":[94],"(KIRP)":[97],"Liver":[99],"hepatocellular":[100],"(LIHC).":[102],"data":[104,135],"from":[105,136],"Cancer":[107],"Genome":[108],"Atlas":[109],"(TCGA)":[110],"Genotype-Tissue":[112],"Expression":[113],"(GTEx)":[114],"databases":[115],"showed":[116,169],"elevated":[121],"significantly":[126],"stage":[130],"patient":[132],"survival.":[133],"Furthermore,":[134],"The":[137],"Tumor":[138],"Immunity":[139],"Estimation":[140],"Resource":[141],"(TIMER)":[142],"database":[143],"indicated":[144],"closely":[151],"related":[152],"to":[153],"degree":[155],"immune":[157],"infiltration":[158],"addition,":[162],"Gene":[163],"Set":[164],"Enrichment":[165],"Analysis":[166],"(GSEA)":[167],"analysis":[168],"DNA":[176],"replication,":[177],"homologous":[178],"recombination,":[179],"linoleic":[180],"acid":[181],"metabolism":[182],"primary":[184],"immunodeficiency.":[185],"conclusion,":[187],"study":[190],"suggested":[191],"may":[194,203],"be":[195],"a":[196,206],"new":[197],"marker":[198],"molecule":[199,209],"for":[200,210],"serve":[204],"as":[205],"targeted":[207],"therapeutic":[208]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}