{"id":"https://openalex.org/W4285014013","doi":"https://doi.org/10.1145/3535694.3535701","title":"An Integreated Method for Mass Spectrometry-based proteomics analysis of Single Cell by using online sample preparation on a monolithic column","display_name":"An Integreated Method for Mass Spectrometry-based proteomics analysis of Single Cell by using online sample preparation on a monolithic column","publication_year":2022,"publication_date":"2022-04-20","ids":{"openalex":"https://openalex.org/W4285014013","doi":"https://doi.org/10.1145/3535694.3535701"},"language":"en","primary_location":{"id":"doi:10.1145/3535694.3535701","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3535694.3535701","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 12th International Conference on Biomedical Engineering and Technology","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101872825","display_name":"Xin-Yi Liu","orcid":"https://orcid.org/0000-0003-1374-5178"},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Liu","raw_affiliation_strings":["School of Biological Science and Medicine Engineering, Southeast University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Science and Medicine Engineering, Southeast University, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021711654","display_name":"Dong Wei","orcid":"https://orcid.org/0000-0002-5727-0998"},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Wei","raw_affiliation_strings":["School of Biological Science and Medicine Engineering, Southeast University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Science and Medicine Engineering, Southeast University, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100392410","display_name":"Haiyang Zhang","orcid":"https://orcid.org/0000-0002-3303-8975"},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyang Zhang","raw_affiliation_strings":["School of Biomedical Engineering, Suzhou University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Suzhou University, China","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034315697","display_name":"Jie Sun","orcid":"https://orcid.org/0000-0002-7394-3013"},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Sun","raw_affiliation_strings":["School of Biological Science and Medicine Engineering, Southeast University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Science and Medicine Engineering, Southeast University, China","institution_ids":["https://openalex.org/I76569877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"34","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.6091393828392029},{"id":"https://openalex.org/keywords/hela","display_name":"HeLa","score":0.6036196947097778},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.5860896110534668},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.5829070806503296},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"Single-cell analysis","score":0.5769833326339722},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5369702577590942},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4925025403499603},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.4100201725959778},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18475127220153809}],"concepts":[{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6091393828392029},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.6036196947097778},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5860896110534668},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5829070806503296},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.5769833326339722},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5369702577590942},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4925025403499603},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4100201725959778},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18475127220153809},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3535694.3535701","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3535694.3535701","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 12th International Conference on Biomedical Engineering and Technology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.5,"id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2037837681","https://openalex.org/W2039058260","https://openalex.org/W2094588994","https://openalex.org/W2313751071","https://openalex.org/W4250571703"],"related_works":["https://openalex.org/W2319590788","https://openalex.org/W2373307992","https://openalex.org/W2357943637","https://openalex.org/W2372231441","https://openalex.org/W2375824005","https://openalex.org/W2350526420","https://openalex.org/W2381761676","https://openalex.org/W2350373849","https://openalex.org/W2361676330","https://openalex.org/W4292341175"],"abstract_inverted_index":{"Cell":[0],"heterogeneity":[1,15],"exists":[2],"in":[3,13,19],"different":[4,8],"cell":[5,14,54,88],"types":[6],"and":[7,22,41,83,161],"subcelluar":[9],"populations.":[10],"The":[11,66,123,140],"studies":[12],"provide":[16],"deep":[17],"understanding":[18],"cancer":[20],"therapy":[21],"drug":[23],"responses.":[24],"However,":[25],"due":[26],"to":[27,131,157],"the":[28,69,115,127,132,158,175],"low":[29],"amount":[30],"of":[31,38,52,81,126,135,143,164,174],"proteins":[32,82,136,149],"from":[33,137,152],"single":[34,53,138],"cell,":[35],"single-cell":[36],"characterization":[37],"metabolites,":[39],"proteins,":[40],"post-translational":[42],"modifications":[43],"remains":[44],"challenging.":[45],"Thus,":[46],"new":[47,169],"methods":[48],"for":[49,76,171],"proteomics":[50],"analysis":[51],"are":[55],"highly":[56],"demanded.":[57],"In":[58],"this":[59,165],"work,":[60],"a":[61],"monolithic":[62,116],"column":[63,117],"was":[64,71,101,146],"prepared.":[65],"surface":[67],"inside":[68],"capillary":[70],"modified":[72],"with":[73,109],"functional":[74],"monomer":[75],"reverse":[77],"phrase":[78],"chromatography-based":[79],"enrichment":[80],"subsequent":[84],"online":[85],"digestion.":[86],"Then,":[87],"contents":[89],"were":[90,112,150],"directly":[91],"analyzed":[92],"on":[93],"electrospray":[94],"ionization":[95],"mass":[96,111],"spectromety.":[97],"This":[98],"intergrated":[99],"method":[100,145],"evaluated":[102],"by":[103],"internal":[104],"label.":[105],"iRT":[106],"standard":[107],"peptides":[108],"known":[110],"injected":[113],"into":[114],"as":[118],"an":[119],"intracellular":[120],"primary":[121],"peptides.":[122],"loss":[124,133,141,160],"rate":[125,134,142],"label":[128],"peptide":[129],"equals":[130],"cell.":[139,155],"integrated":[144],"70%.":[147],"790":[148],"identified":[151],"one":[153],"Hela":[154],"According":[156],"lower":[159],"shorter":[162],"time":[163],"method,":[166],"it":[167],"provides":[168],"tools":[170],"spatial":[172],"detection":[173],"human":[176],"tissue.":[177]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
