{"id":"https://openalex.org/W4226193433","doi":"https://doi.org/10.1145/3507548.3507577","title":"Prediction of Hepatocellular Carcinoma Diseases Based on Methylation Data and Screening of Hub Genes","display_name":"Prediction of Hepatocellular Carcinoma Diseases Based on Methylation Data and Screening of Hub Genes","publication_year":2021,"publication_date":"2021-12-04","ids":{"openalex":"https://openalex.org/W4226193433","doi":"https://doi.org/10.1145/3507548.3507577"},"language":"en","primary_location":{"id":"doi:10.1145/3507548.3507577","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3507548.3507577","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 5th International Conference on Computer Science and Artificial Intelligence","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108774209","display_name":"Yawei Zhang","orcid":"https://orcid.org/0000-0002-7058-2347"},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yawei Zhang","raw_affiliation_strings":["School of computer and information engineering, Henan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of computer and information engineering, Henan University, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010854518","display_name":"Fangtao Ren","orcid":null},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangtao Ren","raw_affiliation_strings":["School of computer and information engineering, Henan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of computer and information engineering, Henan University, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100450808","display_name":"Xi Liu","orcid":"https://orcid.org/0000-0002-7287-9339"},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Liu","raw_affiliation_strings":["School of computer and information engineering, Henan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of computer and information engineering, Henan University, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100403556","display_name":"Fan Zhang","orcid":"https://orcid.org/0000-0003-2176-3835"},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Zhang","raw_affiliation_strings":["Henan Key Laboratory of Big Data Analysis and Processing, Henan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Big Data Analysis and Processing, Henan University, China","institution_ids":["https://openalex.org/I173899330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I173899330"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31346165,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"188","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7421349287033081},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6703115701675415},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.6178648471832275},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5529638528823853},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.5516102910041809},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.5159302949905396},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.5023093223571777},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47294068336486816},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42605993151664734},{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.4166394770145416},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.357136070728302},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.33688580989837646},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.22959324717521667},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21306970715522766}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7421349287033081},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6703115701675415},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6178648471832275},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5529638528823853},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5516102910041809},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5159302949905396},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5023093223571777},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47294068336486816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42605993151664734},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.4166394770145416},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.357136070728302},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.33688580989837646},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.22959324717521667},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21306970715522766}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3507548.3507577","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3507548.3507577","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 5th International Conference on Computer Science and Artificial Intelligence","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5799999833106995,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W2069388901","https://openalex.org/W2521680052","https://openalex.org/W2625559053","https://openalex.org/W2805310212","https://openalex.org/W2810690816","https://openalex.org/W2889646458","https://openalex.org/W2904290041","https://openalex.org/W2910511485","https://openalex.org/W2922464461","https://openalex.org/W2955230524","https://openalex.org/W2997707538","https://openalex.org/W2998558339","https://openalex.org/W3001376117","https://openalex.org/W3012676688","https://openalex.org/W3023883776","https://openalex.org/W3035715385","https://openalex.org/W3039591374","https://openalex.org/W3041911350","https://openalex.org/W3066552266","https://openalex.org/W3087179353"],"related_works":["https://openalex.org/W2169344098","https://openalex.org/W2944524138","https://openalex.org/W2364944693","https://openalex.org/W2123238153","https://openalex.org/W2582088144","https://openalex.org/W4200236841","https://openalex.org/W170658859","https://openalex.org/W1483316219","https://openalex.org/W4310366902","https://openalex.org/W3023720143"],"abstract_inverted_index":{"DNA":[0,20,67,139],"methylation":[1,21,58,68,140],"is":[2],"of":[3,13,71,101,131,197],"great":[4],"significance":[5],"to":[6,34,111],"the":[7,35,66,72,76,84,99,102,156,168,174,192],"diagnosis,":[8,193],"treatment":[9,194],"and":[10,27,60,83,121,166,195],"disease":[11,45,119,135],"prediction":[12,120,136,147],"hepatocellular":[14],"carcinoma":[15],"(HCC).":[16],"The":[17,125],"commonly":[18],"used":[19,97,188],"microarrays":[22],"have":[23],"high":[24],"data":[25,59,70,80,103],"dimensions,":[26],"different":[28],"CpG":[29],"sites":[30],"detected":[31],"may":[32],"map":[33],"same":[36],"gene.":[37],"To":[38],"extract":[39],"more":[40],"effective":[41],"features":[42],"for":[43,117,133,191],"HCC":[44,118,134,146],"prediction,":[46],"this":[47,149],"study":[48],"uses":[49],"a":[50,113],"linear":[51],"regression":[52],"model":[53,116,127],"that":[54],"integrates":[55],"TCGA":[56],"database":[57,74],"gene":[61,78],"expression":[62,79],"data,":[63],"based":[64,137],"on":[65,138],"microarray":[69,141],"GEO":[73],"(GSE113017),":[75],"corresponding":[77],"was":[81,96],"predicted":[82],"differentially":[85,157],"expressed":[86,158],"genes":[87,159,172],"(3766)":[88],"with":[89,144,160],"significant":[90],"differences":[91],"were":[92],"screened":[93],"out,":[94],"which":[95,185],"as":[98,176,189],"feature":[100],"set.":[104],"Constructing":[105],"an":[106,129],"Artificial":[107],"Neural":[108],"Network":[109],"(ANN)":[110],"train":[112],"machine":[114],"learning":[115],"perform":[122],"10-fold":[123],"cross-validation.":[124],"resulting":[126],"has":[128,151],"accuracy":[130],"95.1%":[132],"data.":[142],"Compared":[143],"other":[145],"methods,":[148],"method":[150],"better":[152],"performance.":[153],"Then":[154],"analyze":[155],"protein-protein":[161],"interaction":[162],"network":[163,175],"(PPI":[164],"network),":[165],"use":[167],"top":[169],"five":[170],"connected":[171],"in":[173],"hub":[177],"genes,":[178],"namely:":[179],"GNGT2,":[180],"GNB4,":[181],"FPR2,":[182],"CDC20,":[183],"NMUR1,":[184],"can":[186],"be":[187],"biomarkers":[190],"prognosis":[196],"HCC.":[198]},"counts_by_year":[],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}
