{"id":"https://openalex.org/W4213198258","doi":"https://doi.org/10.1145/3502060.3502320","title":"The Role of miR-21 on the Expression of \u03b22-Microglobulin in Steroid-resistant Nephrotic Syndrome Children","display_name":"The Role of miR-21 on the Expression of \u03b22-Microglobulin in Steroid-resistant Nephrotic Syndrome Children","publication_year":2021,"publication_date":"2021-08-13","ids":{"openalex":"https://openalex.org/W4213198258","doi":"https://doi.org/10.1145/3502060.3502320"},"language":"en","primary_location":{"id":"doi:10.1145/3502060.3502320","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3502060.3502320","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 International Symposium on Biomedical Engineering and Computational Biology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021172048","display_name":"Dany Hilmanto","orcid":"https://orcid.org/0000-0003-3684-4144"},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Dany Hilmanto","raw_affiliation_strings":["Child Health,Faculty of Medicine, Universitas Padjadjaran, Indonesia"],"affiliations":[{"raw_affiliation_string":"Child Health,Faculty of Medicine, Universitas Padjadjaran, Indonesia","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074542453","display_name":"Ahmedz Widiasta","orcid":"https://orcid.org/0000-0001-5664-089X"},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Ahmedz Widiasta","raw_affiliation_strings":["Child Health,Faculty of Medicine, Universitas Padjadjaran, Indonesia"],"affiliations":[{"raw_affiliation_string":"Child Health,Faculty of Medicine, Universitas Padjadjaran, Indonesia","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000512240","display_name":"Yunia Sribudiani","orcid":"https://orcid.org/0000-0003-1985-3292"},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Yunia Sribudiani","raw_affiliation_strings":["Child Health,Faculty of Medicine, Universitas Padjadjaran, Indonesia"],"affiliations":[{"raw_affiliation_string":"Child Health,Faculty of Medicine, Universitas Padjadjaran, Indonesia","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003132434","display_name":"Husna Nugrahapraja","orcid":"https://orcid.org/0000-0002-7637-272X"},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Husna Nugrahapraja","raw_affiliation_strings":["Child Health,Faculty of Medicine, Universitas Padjadjaran, Indonesia"],"affiliations":[{"raw_affiliation_string":"Child Health,Faculty of Medicine, Universitas Padjadjaran, Indonesia","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091549011","display_name":"Kurnia Wahyudi","orcid":"https://orcid.org/0000-0002-7566-8457"},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Kurnia Wahyudi","raw_affiliation_strings":["Child Health,Faculty of Medicine, Universitas Padjadjaran, Indonesia"],"affiliations":[{"raw_affiliation_string":"Child Health,Faculty of Medicine, Universitas Padjadjaran, Indonesia","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113702456","display_name":"Dedi Rachmadi","orcid":"https://orcid.org/0000-0002-4561-9056"},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Dedi Rachmadi","raw_affiliation_strings":["Child Health,Faculty of Medicine, Universitas Padjadjaran, Indonesia"],"affiliations":[{"raw_affiliation_string":"Child Health,Faculty of Medicine, Universitas Padjadjaran, Indonesia","institution_ids":["https://openalex.org/I91819753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5021172048"],"corresponding_institution_ids":["https://openalex.org/I91819753"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23840651,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-2-microglobulin","display_name":"Beta-2 microglobulin","score":0.7948901653289795},{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"Nephrotic syndrome","score":0.7883917093276978},{"id":"https://openalex.org/keywords/downregulation-and-upregulation","display_name":"Downregulation and upregulation","score":0.6910166144371033},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5670396089553833},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.5345209240913391},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.46743789315223694},{"id":"https://openalex.org/keywords/spearmans-rank-correlation-coefficient","display_name":"Spearman's rank correlation coefficient","score":0.4647698998451233},{"id":"https://openalex.org/keywords/rank-correlation","display_name":"Rank correlation","score":0.42896491289138794},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.41410383582115173},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.36696475744247437},{"id":"https://openalex.org/keywords/gastroenterology","display_name":"Gastroenterology","score":0.35780787467956543},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2414679229259491},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.0984836220741272},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09557130932807922},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.07255822420120239}],"concepts":[{"id":"https://openalex.org/C21957315","wikidata":"https://www.wikidata.org/wiki/Q287896","display_name":"Beta-2 microglobulin","level":2,"score":0.7948901653289795},{"id":"https://openalex.org/C2778930706","wikidata":"https://www.wikidata.org/wiki/Q504790","display_name":"Nephrotic syndrome","level":2,"score":0.7883917093276978},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6910166144371033},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5670396089553833},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5345209240913391},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.46743789315223694},{"id":"https://openalex.org/C159744936","wikidata":"https://www.wikidata.org/wiki/Q1126730","display_name":"Spearman's rank correlation coefficient","level":2,"score":0.4647698998451233},{"id":"https://openalex.org/C101601086","wikidata":"https://www.wikidata.org/wiki/Q3753228","display_name":"Rank correlation","level":2,"score":0.42896491289138794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41410383582115173},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36696475744247437},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35780787467956543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2414679229259491},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0984836220741272},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09557130932807922},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07255822420120239},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3502060.3502320","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3502060.3502320","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 International Symposium on Biomedical Engineering and Computational Biology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7699999809265137,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1983889464","https://openalex.org/W1990694891","https://openalex.org/W2026477188","https://openalex.org/W2026570544","https://openalex.org/W2030084418","https://openalex.org/W2047702454","https://openalex.org/W2050176963","https://openalex.org/W2060995136","https://openalex.org/W2080727979","https://openalex.org/W2102135172","https://openalex.org/W2102895846","https://openalex.org/W2107277218","https://openalex.org/W2112875301","https://openalex.org/W2117391818","https://openalex.org/W2129566974","https://openalex.org/W2151383898","https://openalex.org/W2163543028","https://openalex.org/W2181911257","https://openalex.org/W2395733179","https://openalex.org/W2531928944","https://openalex.org/W2568946527","https://openalex.org/W2618084763","https://openalex.org/W2735466792","https://openalex.org/W2792920708","https://openalex.org/W2797273941","https://openalex.org/W2901699085","https://openalex.org/W2911557501","https://openalex.org/W3015387663","https://openalex.org/W3025605341","https://openalex.org/W3047748518","https://openalex.org/W4249614921","https://openalex.org/W6605913020"],"related_works":["https://openalex.org/W2096962026","https://openalex.org/W2319525095","https://openalex.org/W4251214348","https://openalex.org/W4246497475","https://openalex.org/W2368363712","https://openalex.org/W2031235730","https://openalex.org/W2153289787","https://openalex.org/W1491924921","https://openalex.org/W2354721754","https://openalex.org/W2562018983"],"abstract_inverted_index":{"Nephrotic":[0],"syndrome":[1],"(NS)":[2],"in":[3,9,25,57,91,135,169,190],"children":[4,49,170],"has":[5],"some":[6],"mysterious":[7],"prognosis":[8],"the":[10,21,112,127,152,176],"perspective":[11],"of":[12,23,47,133,154,179],"its":[13],"therapeutic":[14],"response.":[15],"This":[16,173],"study":[17,36],"aims":[18],"to":[19,66,138],"determine":[20],"role":[22],"miR-21":[24,97,117,134,155,166],"\u03b2-2":[26],"microglobulin":[27],"(B2M)":[28],"expression":[29,98,107,118,150,177],"among":[30],"SRNS":[31,77,136,188],"children.":[32,191],"The":[33,69,103,165],"open-prospective":[34],"cohort":[35],"was":[37,83,99,146],"conducted":[38],"at":[39,94],"Hasan":[40],"Sadikin":[41],"General":[42],"Hospital,":[43],"Indonesia.":[44],"A":[45],"total":[46],"24":[48],"(age":[50],"1\u201318":[51],"years)":[52],"with":[53,86,109,151,171],"NS":[54],"were":[55,63,73,119,130],"enrolled":[56],"this":[58,180],"study.":[59],"Meanwhile,":[60],"blood":[61,71,87],"samples":[62,72,89],"collected":[64,74],"prior":[65],"any":[67],"treatment.":[68],"whole":[70],"from":[75],"12":[76],"and":[78,111,116],"control.":[79],"Moreover,":[80],"RNA":[81],"isolation":[82],"carried":[84],"out":[85],"plasma":[88],"stored":[90],"a":[92,185],"cooler":[93],"-800C,":[95],"while":[96],"measured":[100],"using":[101,121],"qRT-PCR.":[102],"difference":[104],"between":[105,114,148],"miRNAs":[106],"analyzed":[108,120],"Livak":[110],"correlation":[113,123,145],"B2M":[115,149],"Spearman":[122],"analysis.":[124],"Based":[125],"on":[126],"results,":[128],"there":[129],"notable":[131],"upregulation":[132,153],"compared":[137],"SSNS":[139],"2-\u0394\u0394Ct":[140],">":[141,163],"1.":[142],"However,":[143],"no":[144],"observed":[147],"(":[156],"-1":[157],"<":[158,160],"rs":[159],"1,":[161],"p":[162],"0.05).":[164],"is":[167],"upregulated":[168],"SRNS.":[172],"indicates":[174],"that":[175],"level":[178],"miRNA":[181],"potentially":[182],"applicable":[183],"as":[184],"predictor":[186],"for":[187],"development":[189]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}