{"id":"https://openalex.org/W4200114688","doi":"https://doi.org/10.1145/3500931.3500983","title":"Optimization of Conditions for Ginsenoside Re liposomes Production by Response Surface Methodology","display_name":"Optimization of Conditions for Ginsenoside Re liposomes Production by Response Surface Methodology","publication_year":2021,"publication_date":"2021-10-29","ids":{"openalex":"https://openalex.org/W4200114688","doi":"https://doi.org/10.1145/3500931.3500983"},"language":"en","primary_location":{"id":"doi:10.1145/3500931.3500983","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3500931.3500983","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2nd International Symposium on Artificial Intelligence for Medicine Sciences","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100459030","display_name":"Yujie Chen","orcid":"https://orcid.org/0000-0001-7970-8893"},"institutions":[{"id":"https://openalex.org/I55538621","display_name":"China Jiliang University","ror":"https://ror.org/05v1y0t93","country_code":"CN","type":"education","lineage":["https://openalex.org/I55538621"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yujie Chen","raw_affiliation_strings":["College of Life Sciences, China Jiliang University, Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences, China Jiliang University, Hangzhou, China","institution_ids":["https://openalex.org/I55538621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033909995","display_name":"Rongfa Guan","orcid":"https://orcid.org/0000-0002-2717-0996"},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongfa Guan","raw_affiliation_strings":["College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, P. R. China"],"affiliations":[{"raw_affiliation_string":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, P. R. China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020084763","display_name":"Haizhi Huang","orcid":"https://orcid.org/0000-0002-9816-0269"},"institutions":[{"id":"https://openalex.org/I55538621","display_name":"China Jiliang University","ror":"https://ror.org/05v1y0t93","country_code":"CN","type":"education","lineage":["https://openalex.org/I55538621"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haizhi Huang","raw_affiliation_strings":["College of Life Sciences, China Jiliang University, Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences, China Jiliang University, Hangzhou, China","institution_ids":["https://openalex.org/I55538621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101414013","display_name":"Hao Zhong","orcid":"https://orcid.org/0000-0002-5957-5365"},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Zhong","raw_affiliation_strings":["College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, P. R. China"],"affiliations":[{"raw_affiliation_string":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, P. R. China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101466851","display_name":"Yujing Sun","orcid":"https://orcid.org/0000-0002-0449-2917"},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujing Sun","raw_affiliation_strings":["College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, P. R. China"],"affiliations":[{"raw_affiliation_string":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, P. R. China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100699824","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0001-7275-4408"},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, P. R. China"],"affiliations":[{"raw_affiliation_string":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, P. R. China","institution_ids":["https://openalex.org/I55712492"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100459030"],"corresponding_institution_ids":["https://openalex.org/I55538621"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12304746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"296","last_page":"300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.9696000218391418,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13670","display_name":"Ziziphus Jujuba Studies and Applications","score":0.9239000082015991,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liposome","display_name":"Liposome","score":0.9476596117019653},{"id":"https://openalex.org/keywords/particle-size","display_name":"Particle size","score":0.6502621173858643},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"Phosphatidylcholine","score":0.6284875273704529},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.6234670877456665},{"id":"https://openalex.org/keywords/transmission-electron-microscopy","display_name":"Transmission electron microscopy","score":0.6047821640968323},{"id":"https://openalex.org/keywords/response-surface-methodology","display_name":"Response surface methodology","score":0.5168088674545288},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.4767668843269348},{"id":"https://openalex.org/keywords/microstructure","display_name":"Microstructure","score":0.47454962134361267},{"id":"https://openalex.org/keywords/dispersion","display_name":"Dispersion (optics)","score":0.446005254983902},{"id":"https://openalex.org/keywords/particle","display_name":"Particle (ecology)","score":0.4315280318260193},{"id":"https://openalex.org/keywords/analytical-chemistry","display_name":"Analytical Chemistry (journal)","score":0.33520716428756714},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3186911642551422},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.2805432081222534},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.13043242692947388},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.10106587409973145},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.08940711617469788},{"id":"https://openalex.org/keywords/phospholipid","display_name":"Phospholipid","score":0.07791110873222351},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.06924355030059814}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.9476596117019653},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.6502621173858643},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.6284875273704529},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6234670877456665},{"id":"https://openalex.org/C146088050","wikidata":"https://www.wikidata.org/wiki/Q744818","display_name":"Transmission electron microscopy","level":2,"score":0.6047821640968323},{"id":"https://openalex.org/C150077022","wikidata":"https://www.wikidata.org/wiki/Q3136137","display_name":"Response surface methodology","level":2,"score":0.5168088674545288},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4767668843269348},{"id":"https://openalex.org/C87976508","wikidata":"https://www.wikidata.org/wiki/Q1498213","display_name":"Microstructure","level":2,"score":0.47454962134361267},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.446005254983902},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.4315280318260193},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.33520716428756714},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3186911642551422},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2805432081222534},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.13043242692947388},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.10106587409973145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08940711617469788},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.07791110873222351},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06924355030059814},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3500931.3500983","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3500931.3500983","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2nd International Symposium on Artificial Intelligence for Medicine Sciences","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1255350847","https://openalex.org/W1936545528","https://openalex.org/W2022584571","https://openalex.org/W2023140941","https://openalex.org/W2097351629","https://openalex.org/W2117228502","https://openalex.org/W2141432321","https://openalex.org/W2179596048","https://openalex.org/W2281263790","https://openalex.org/W2312587484","https://openalex.org/W2388624855","https://openalex.org/W2530565034","https://openalex.org/W2553203191","https://openalex.org/W2777047058","https://openalex.org/W2800781897","https://openalex.org/W2804846127","https://openalex.org/W2889004114","https://openalex.org/W2898604130","https://openalex.org/W2899542683","https://openalex.org/W2907884779","https://openalex.org/W2946446720","https://openalex.org/W2970543069","https://openalex.org/W3010640975","https://openalex.org/W3084413715"],"related_works":["https://openalex.org/W2018639796","https://openalex.org/W2038849775","https://openalex.org/W2079657570","https://openalex.org/W2002600686","https://openalex.org/W2022639798","https://openalex.org/W2104822404","https://openalex.org/W2082912961","https://openalex.org/W192157194","https://openalex.org/W2070868045","https://openalex.org/W264325884"],"abstract_inverted_index":{"In":[0],"this":[1,64],"study,":[2],"we":[3],"aimed":[4],"to":[5],"optimize":[6],"the":[7,22,28,59,83,86,119],"formulation":[8],"of":[9,24,32,69,73,79,91,121],"Ginsenoside":[10],"Re":[11],"liposomes":[12,34,93,105,115],"using":[13],"response":[14],"surface":[15],"methodology.":[16],"A":[17],"transmission":[18],"electron":[19],"microscope":[20],"observed":[21],"morphology":[23],"G-Re":[25,33,92,104],"liposomes.":[26],"Additionally,":[27],"microstructure":[29],"and":[30,49,75,89,99],"size":[31,40,88],"were":[35,94],"determined":[36],"by":[37],"a":[38,47,107,111],"particle":[39,87],"analyzer.":[41],"The":[42,55,103,114],"film":[43],"dispersion":[44],"method":[45,51,65],"is":[46],"simple":[48],"efficient":[50],"for":[52,63],"liposome":[53],"preparation.":[54],"results":[56],"showed":[57,106],"that":[58],"optimal":[60,84],"preparation":[61],"conditions":[62],"were:":[66],"phosphatidylcholine/Re":[67],"ratio":[68,72],"33.68,":[70],"phosphatidylcholine/cholesterol":[71],"10.19,":[74],"rotary":[76],"evaporation":[77],"temperature":[78],"48.50":[80],"\u00b0C.":[81],"Under":[82],"conditions,":[85],"EE":[90],"173.87":[95],"\u00b1":[96],"4.74":[97],"nm":[98],"60.91%":[100],"\u00b11.53,":[101],"respectively.":[102],"spherical":[108],"structure":[109],"with":[110],"smooth":[112],"surface.":[113],"as":[116],"carriers":[117],"improved":[118],"stability":[120],"G-Re.":[122]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}