{"id":"https://openalex.org/W4210757694","doi":"https://doi.org/10.1145/3498731.3498739","title":"Activation of Microglial Genes and Crosstalk with Micro-environment in Modulating Immunological Pathology in Alzheimer's Disease","display_name":"Activation of Microglial Genes and Crosstalk with Micro-environment in Modulating Immunological Pathology in Alzheimer's Disease","publication_year":2021,"publication_date":"2021-10-29","ids":{"openalex":"https://openalex.org/W4210757694","doi":"https://doi.org/10.1145/3498731.3498739"},"language":"en","primary_location":{"id":"doi:10.1145/3498731.3498739","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3498731.3498739","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 10th International Conference on Bioinformatics and Biomedical Science","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028741978","display_name":"Chuan Wu","orcid":"https://orcid.org/0000-0003-2288-353X"},"institutions":[{"id":"https://openalex.org/I4210155796","display_name":"Shanghai Jinyuan Senior High School","ror":"https://ror.org/05g2egb88","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210155796"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chuan Wu","raw_affiliation_strings":["Beijing No.80 High School, China"],"affiliations":[{"raw_affiliation_string":"Beijing No.80 High School, China","institution_ids":["https://openalex.org/I4210155796"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028741978"],"corresponding_institution_ids":["https://openalex.org/I4210155796"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22952073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"54","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microglia","display_name":"Microglia","score":0.972671627998352},{"id":"https://openalex.org/keywords/trem2","display_name":"TREM2","score":0.7726283073425293},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6797390580177307},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5787188410758972},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.506885826587677},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.4912223219871521},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"Neuroinflammation","score":0.4419858157634735},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.4376183748245239},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.43335703015327454},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.4130484461784363},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.40547725558280945},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.36095309257507324},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.3165014982223511},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3133951425552368}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.972671627998352},{"id":"https://openalex.org/C2779685842","wikidata":"https://www.wikidata.org/wiki/Q18040973","display_name":"TREM2","level":4,"score":0.7726283073425293},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6797390580177307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5787188410758972},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.506885826587677},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4912223219871521},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4419858157634735},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4376183748245239},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43335703015327454},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4130484461784363},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40547725558280945},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.36095309257507324},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3165014982223511},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3133951425552368},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3498731.3498739","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3498731.3498739","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 10th International Conference on Bioinformatics and Biomedical Science","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W258415298","https://openalex.org/W2059996790","https://openalex.org/W2070050178","https://openalex.org/W2098023402","https://openalex.org/W2105559737","https://openalex.org/W2114104545","https://openalex.org/W2146512944","https://openalex.org/W2157648547","https://openalex.org/W2259938310","https://openalex.org/W2329336071","https://openalex.org/W2406250479","https://openalex.org/W2622807556","https://openalex.org/W2896689039","https://openalex.org/W2899174889","https://openalex.org/W2904483712","https://openalex.org/W2928665623","https://openalex.org/W2947805301","https://openalex.org/W2961845320","https://openalex.org/W2969940182","https://openalex.org/W2975507539","https://openalex.org/W3111509171","https://openalex.org/W4211238543"],"related_works":["https://openalex.org/W4283317699","https://openalex.org/W4308968236","https://openalex.org/W2763445772","https://openalex.org/W4360609725","https://openalex.org/W4385372854","https://openalex.org/W2965172925","https://openalex.org/W4376648595","https://openalex.org/W2622807556","https://openalex.org/W4229004030","https://openalex.org/W4281290245"],"abstract_inverted_index":{"Recent":[0],"studies":[1,30],"have":[2],"revealed":[3,129],"that":[4,104,175,189,199],"immune":[5,135,182],"responses":[6,136,183],"and":[7,26,47,79,113,144,149,173,204,211],"related":[8],"pathways":[9],"are":[10],"actively":[11],"involved":[12],"into":[13],"the":[14,33,42,48,54,58,65,74,84,92,123,130,138,145,161,168,187,200,217],"progression":[15,43,112],"of":[16,35,44,60,67,76,133,163,171],"Alzheimer's":[17],"disease":[18,27,36],"(AD)":[19],"/":[20],"AD-like":[21,110],"pathology":[22,46,111,223],"in":[23,63,87,99,141,165,221],"both":[24],"patients":[25],"models.":[28],"Single-cell":[29],"further":[31],"discovered":[32],"accumulation":[34,86],"associated":[37],"microglia":[38,61,77,124,166,181,190,203],"(DAM)":[39],"along":[40],"with":[41,155],"AD":[45],"pro-inflammatory":[49],"activity":[50],"was":[51,106,153],"regulated":[52],"by":[53,120],"Trem2-dependent":[55],"pathways.":[56],"Given":[57],"significance":[59],"population":[62],"mediating":[64],"clearance":[66,220],"plaques,":[68],"it":[69],"is":[70],"important":[71],"to":[72,83],"understand":[73],"mechanism":[75],"activation":[78,132],"their":[80],"response":[81],"changes":[82],"plaque":[85,219],"AD-affected":[88],"brains.":[89],"By":[90],"observing":[91],"gene":[93,125],"expression":[94,126],"level":[95],"across":[96],"brain":[97,225],"regions":[98],"5xFAD":[100,142,148,172],"mice,":[101],"we":[102,128,159,196],"showed":[103,174],"hippocampus":[105],"most":[107,114],"affected":[108,224],"during":[109],"up-regulated":[115],"genes":[116],"were":[117],"pro-inflammatory.":[118],"Then,":[119],"looking":[121],"at":[122,137,167],"data,":[127],"distinguished":[131],"disease-associated":[134],"late":[139,169],"stage":[140,170],"mice":[143,152],"discrepancy":[146],"between":[147,202],"wild":[150],"type":[151],"increased":[154],"aging.":[156],"In":[157],"addition,":[158],"discussed":[160],"importance":[162],"Trem2":[164,176],"knock-out":[177],"not":[178],"only":[179],"decreased":[180],"but":[184],"also":[185],"changed":[186],"micro-environment":[188],"resided":[191],"in.":[192],"Based":[193],"on":[194,216],"this,":[195],"continued":[197],"argued":[198],"interaction":[201],"other":[205],"cell":[206],"types,":[207],"including":[208],"neurons,":[209],"astrocytes":[210],"oligodendrocytes,":[212],"had":[213],"significant":[214],"impacts":[215],"microglia-mediated":[218],"AD/AD-like":[222],"tissues.":[226]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
