{"id":"https://openalex.org/W4210284603","doi":"https://doi.org/10.1145/3498731.3498736","title":"Endogenous Network Reveals the Landscape of Liver Lineage Differentiation","display_name":"Endogenous Network Reveals the Landscape of Liver Lineage Differentiation","publication_year":2021,"publication_date":"2021-10-29","ids":{"openalex":"https://openalex.org/W4210284603","doi":"https://doi.org/10.1145/3498731.3498736"},"language":"en","primary_location":{"id":"doi:10.1145/3498731.3498736","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3498731.3498736","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 10th International Conference on Bioinformatics and Biomedical Science","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100441085","display_name":"Xiao Liu","orcid":"https://orcid.org/0000-0002-8073-0534"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao Liu","raw_affiliation_strings":["Shanghai Center for Quantitative Life Sciences, Shanghai University, China and Department of Physics, Shanghai University, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Center for Quantitative Life Sciences, Shanghai University, China and Department of Physics, Shanghai University, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100761948","display_name":"Mengyao Wang","orcid":"https://orcid.org/0000-0001-7190-331X"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyao Wang","raw_affiliation_strings":["Shanghai Center for Quantitative Life Sciences, Shanghai University, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Center for Quantitative Life Sciences, Shanghai University, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I113940042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037941143","display_name":"Qi Chang","orcid":null},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Chang","raw_affiliation_strings":["Shanghai Center for Quantitative Life Sciences, Shanghai University, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Center for Quantitative Life Sciences, Shanghai University, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I113940042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100441085"],"corresponding_institution_ids":["https://openalex.org/I113940042"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14011264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"31","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.9811000227928162,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9591000080108643,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endogeny","display_name":"Endogeny","score":0.7490456104278564},{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.7381571531295776},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.6790498495101929},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"Cell fate determination","score":0.5501299500465393},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.547732949256897},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5310029983520508},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.46633100509643555},{"id":"https://openalex.org/keywords/liver-cell","display_name":"Liver cell","score":0.45493632555007935},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.44288450479507446},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4360511302947998},{"id":"https://openalex.org/keywords/endoderm","display_name":"Endoderm","score":0.41586852073669434},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3418549597263336},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.320550799369812},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16957971453666687},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.11841994524002075},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1110321581363678},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08812916278839111},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08485168218612671},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07743695378303528}],"concepts":[{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.7490456104278564},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.7381571531295776},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6790498495101929},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.5501299500465393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.547732949256897},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5310029983520508},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.46633100509643555},{"id":"https://openalex.org/C2992672570","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Liver cell","level":2,"score":0.45493632555007935},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.44288450479507446},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4360511302947998},{"id":"https://openalex.org/C2777164004","wikidata":"https://www.wikidata.org/wiki/Q331858","display_name":"Endoderm","level":4,"score":0.41586852073669434},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3418549597263336},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.320550799369812},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16957971453666687},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11841994524002075},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1110321581363678},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08812916278839111},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08485168218612671},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07743695378303528},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3498731.3498736","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3498731.3498736","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 10th International Conference on Bioinformatics and Biomedical Science","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1601840771","https://openalex.org/W1917704994","https://openalex.org/W1968519261","https://openalex.org/W1978125302","https://openalex.org/W1978329448","https://openalex.org/W1978462702","https://openalex.org/W1985342348","https://openalex.org/W1988903498","https://openalex.org/W2018259775","https://openalex.org/W2025982106","https://openalex.org/W2073286325","https://openalex.org/W2117480088","https://openalex.org/W2123743609","https://openalex.org/W2142362599","https://openalex.org/W2151382751","https://openalex.org/W2156590681","https://openalex.org/W2159747138","https://openalex.org/W2160754686","https://openalex.org/W2266782204","https://openalex.org/W2588231937","https://openalex.org/W2625475375","https://openalex.org/W2734110836","https://openalex.org/W2959566316","https://openalex.org/W3001222395","https://openalex.org/W7046503655"],"related_works":["https://openalex.org/W1564861386","https://openalex.org/W2006730050","https://openalex.org/W2063353254","https://openalex.org/W1998993703","https://openalex.org/W2624468404","https://openalex.org/W1995507342","https://openalex.org/W1522194210","https://openalex.org/W2508191807","https://openalex.org/W2888867414","https://openalex.org/W2048939079"],"abstract_inverted_index":{"Revealing":[0],"the":[1,47,63,66,75,84,87,95,103,121,124,128,140,148],"molecular":[2],"regulation":[3],"mechanism":[4,141],"of":[5,10,37,65,77,86,123,127,142,150],"cell":[6,16,72,89,107,144],"fate":[7],"decision":[8],"is":[9,32,35,91,131],"great":[11],"significance":[12,59],"for":[13,28,135],"understanding":[14],"stem":[15],"differentiation":[17,31,76,90,108,115,145],"and":[18,41,54,146],"tissue":[19],"homeostasis.":[20],"In":[21,82],"this":[22],"paper,":[23],"a":[24],"coarse-grained":[25],"endogenous":[26,129],"network":[27,130],"endodermal":[29],"liver":[30,78,88,106,143,151],"constructed,":[33],"which":[34,69],"composed":[36],"five":[38],"transcription":[39],"factors":[40],"their":[42],"interaction":[43],"was":[44],"collected":[45],"from":[46,62,94],"accumulated":[48],"biological":[49,58],"knowledge.":[50],"The":[51],"stable":[52],"states":[53,56,73],"transition":[55],"with":[57],"are":[60],"obtained":[61],"dynamics":[64],"network,":[67],"by":[68],"previously":[70],"unobserved":[71],"during":[74],"cells":[79],"were":[80],"predicted.":[81],"addition,":[83],"landscape":[85,99],"also":[92,111],"predicted":[93],"computing":[96],"results.":[97],"This":[98,117],"not":[100],"only":[101],"contains":[102],"classical":[104],"endoderm":[105],"roadmap;":[109],"but":[110],"predicts":[112],"more":[113,136],"complex":[114],"paths.":[116],"study":[118],"shows":[119],"that":[120],"construction":[122],"dynamic":[125],"model":[126],"an":[132],"effective":[133],"tool":[134],"in-depth":[137],"research":[138],"in":[139],"explain":[147],"genesis":[149],"diseases":[152]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
