{"id":"https://openalex.org/W3216655770","doi":"https://doi.org/10.1145/3487027.3487032","title":"Effect of Inhibiting Upstream Aryl Hydrocarbon Receptor Nuclear Translocator on the TCDD-induced Non-alcoholic Fatty Liver Disease","display_name":"Effect of Inhibiting Upstream Aryl Hydrocarbon Receptor Nuclear Translocator on the TCDD-induced Non-alcoholic Fatty Liver Disease","publication_year":2021,"publication_date":"2021-09-11","ids":{"openalex":"https://openalex.org/W3216655770","doi":"https://doi.org/10.1145/3487027.3487032","mag":"3216655770"},"language":"en","primary_location":{"id":"doi:10.1145/3487027.3487032","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3487027.3487032","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 8th International Conference on Bioinformatics Research and Applications","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028764753","display_name":"Yufei Ye","orcid":null},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Yufei Ye","raw_affiliation_strings":["School of Biology, Queen's University, Canada"],"affiliations":[{"raw_affiliation_string":"School of Biology, Queen's University, Canada","institution_ids":["https://openalex.org/I204722609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028764753"],"corresponding_institution_ids":["https://openalex.org/I204722609"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22311821,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"27","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor-nuclear-translocator","display_name":"Aryl hydrocarbon receptor nuclear translocator","score":0.9693227410316467},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"Aryl hydrocarbon receptor","score":0.8293403387069702},{"id":"https://openalex.org/keywords/fatty-liver","display_name":"Fatty liver","score":0.7267971038818359},{"id":"https://openalex.org/keywords/toxicant","display_name":"Toxicant","score":0.6460398435592651},{"id":"https://openalex.org/keywords/knockout-mouse","display_name":"Knockout mouse","score":0.6362228989601135},{"id":"https://openalex.org/keywords/liver-x-receptor","display_name":"Liver X receptor","score":0.5497671365737915},{"id":"https://openalex.org/keywords/liver-cell","display_name":"Liver cell","score":0.445494681596756},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4448087513446808},{"id":"https://openalex.org/keywords/alcoholic-liver-disease","display_name":"Alcoholic liver disease","score":0.413335382938385},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.3935992121696472},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.378547728061676},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.37682557106018066},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.35944604873657227},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.33441346883773804},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.33124077320098877},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2702849507331848},{"id":"https://openalex.org/keywords/nuclear-receptor","display_name":"Nuclear receptor","score":0.2430250644683838},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1855761706829071},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14814752340316772},{"id":"https://openalex.org/keywords/cirrhosis","display_name":"Cirrhosis","score":0.1316070556640625},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.10267084836959839}],"concepts":[{"id":"https://openalex.org/C45815257","wikidata":"https://www.wikidata.org/wiki/Q109984923","display_name":"Aryl hydrocarbon receptor nuclear translocator","level":5,"score":0.9693227410316467},{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.8293403387069702},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.7267971038818359},{"id":"https://openalex.org/C2780473477","wikidata":"https://www.wikidata.org/wiki/Q3072135","display_name":"Toxicant","level":3,"score":0.6460398435592651},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.6362228989601135},{"id":"https://openalex.org/C167400880","wikidata":"https://www.wikidata.org/wiki/Q3454539","display_name":"Liver X receptor","level":5,"score":0.5497671365737915},{"id":"https://openalex.org/C2992672570","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Liver cell","level":2,"score":0.445494681596756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4448087513446808},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.413335382938385},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3935992121696472},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.378547728061676},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.37682557106018066},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35944604873657227},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33441346883773804},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33124077320098877},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2702849507331848},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.2430250644683838},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1855761706829071},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14814752340316772},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.1316070556640625},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10267084836959839},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3487027.3487032","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3487027.3487032","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 8th International Conference on Bioinformatics Research and Applications","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2044715732","https://openalex.org/W2138743300","https://openalex.org/W2149572095","https://openalex.org/W2762864566","https://openalex.org/W2770129291","https://openalex.org/W2777780841","https://openalex.org/W3006028518","https://openalex.org/W3112900502","https://openalex.org/W3116033488","https://openalex.org/W3119540590","https://openalex.org/W6652567192"],"related_works":["https://openalex.org/W2394599053","https://openalex.org/W2116231282","https://openalex.org/W2002396362","https://openalex.org/W2378346785","https://openalex.org/W2049881818","https://openalex.org/W2060058885","https://openalex.org/W2087122683","https://openalex.org/W2888428812","https://openalex.org/W1981300446","https://openalex.org/W2060065906"],"abstract_inverted_index":{"Environmental":[0],"toxicant":[1],"2,3,7,8-tetrachlorodibenzo-p-dioxin":[2],"(TCDD)":[3],"from":[4],"industrial":[5],"by-product":[6],"is":[7,74,84,118],"a":[8,146],"dominant":[9],"trigger":[10],"of":[11,31,81,187],"Non-alcoholic":[12],"fatty":[13],"liver":[14,41,67,93,108,125,148,164,192],"disease":[15],"(NAFLD)":[16],"that":[17,119],"induces":[18],"an":[19],"excess":[20],"triglycerides":[21],"buildup":[22],"within":[23],"the":[24,40,79,103,123,128,134,157,163,181,191],"liver.":[25],"This":[26,51],"paper":[27],"discusses":[28],"whether":[29],"knockout":[30,75,121,189],"upstream":[32],"Aryl":[33],"hydrocarbon":[34],"receptor":[35],"nuclear":[36],"translocator":[37],"(ARNT)":[38],"relieves":[39],"burden":[42],"in":[43,57,63,111,139,142,182],"preventing":[44],"abnormal":[45],"lipid":[46],"accumulation":[47],"after":[48],"TCDD":[49],"exposure.":[50],"experiment":[52],"utilizes":[53],"two":[54],"models":[55,144],"(1)":[56],"vivo":[58,143],"mice":[59],"model":[60,170],"and":[61,78,96,107,141,193],"(2)":[62],"vitro":[64,140],"human":[65],"normal":[66],"cell":[68,109],"line":[69],"model.":[70],"The":[71,114,150],"ARNT":[72,120,188],"gene":[73,105,136,159],"by":[76],"CRISPR,":[77],"expression":[80],"AhR-ARNT":[82],"complex":[83],"detected.":[85],"Intracellular":[86],"copper":[87],"transport":[88],"assay,":[89],"mitochondrial":[90],"OCR":[91],"analysis,":[92],"function":[94],"test":[95],"histology":[97],"are":[98],"then":[99],"used":[100],"to":[101,173],"observe":[102],"ARNT-/-":[104],"regulation":[106,160],"responses":[110],"both":[112,138],"models.":[113],"most":[115],"possible":[116],"result":[117],"inhibits":[122],"TCDD-induced":[124],"toxicity":[126],"at":[127],"initial":[129],"binding":[130],"site":[131],"without":[132],"affecting":[133],"downstream":[135],"regulation;":[137],"present":[145],"healthy":[147],"state.":[149],"results":[151],"will":[152],"contribute":[153],"crucial":[154],"information":[155],"on":[156,179,190],"TCDD-elicited":[158],"mechanism":[161],"inside":[162],"cell,":[165],"providing":[166],"detailed":[167],"environmental":[168],"toxicant-triggered":[169],"studies":[171,176],"relate":[172],"NAFLD.":[174],"Prospective":[175],"should":[177],"focus":[178],"investigating":[180],"detail":[183],"potential":[184],"side":[185],"effects":[186],"other":[194],"relative":[195],"organs.":[196]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
