{"id":"https://openalex.org/W4206062158","doi":"https://doi.org/10.1145/3473258.3473283","title":"NSCLC: Exploring the Robust States of the Endogenous Molecular-cellular Network","display_name":"NSCLC: Exploring the Robust States of the Endogenous Molecular-cellular Network","publication_year":2021,"publication_date":"2021-05-21","ids":{"openalex":"https://openalex.org/W4206062158","doi":"https://doi.org/10.1145/3473258.3473283"},"language":"en","primary_location":{"id":"doi:10.1145/3473258.3473283","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3473258.3473283","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 13th International Conference on Bioinformatics and Biomedical Technology","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037941143","display_name":"Qi Chang","orcid":null},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Chang","raw_affiliation_strings":["Shanghai University and Shanghai University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University and Shanghai University, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100761948","display_name":"Mengyao Wang","orcid":"https://orcid.org/0000-0001-7190-331X"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyao Wang","raw_affiliation_strings":["Shanghai University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100441034","display_name":"Xiao Liu","orcid":"https://orcid.org/0000-0001-8354-4000"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Liu","raw_affiliation_strings":["Shanghai University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University, China","institution_ids":["https://openalex.org/I113940042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I113940042"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"163","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9830999970436096,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomedicine","display_name":"Biomedicine","score":0.6886391639709473},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.6348170638084412},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6064900159835815},{"id":"https://openalex.org/keywords/endogeny","display_name":"Endogeny","score":0.544851541519165},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5210915803909302},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.501978874206543},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.48985573649406433},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4641057252883911},{"id":"https://openalex.org/keywords/network-theory","display_name":"Network theory","score":0.4630226492881775},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4619392156600952},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4610331356525421},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44048359990119934},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.36053985357284546},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3126755356788635},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.25941556692123413},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22855612635612488},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20571210980415344},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.15604296326637268},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.10609227418899536}],"concepts":[{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.6886391639709473},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6348170638084412},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6064900159835815},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.544851541519165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5210915803909302},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.501978874206543},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.48985573649406433},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4641057252883911},{"id":"https://openalex.org/C11804174","wikidata":"https://www.wikidata.org/wiki/Q1192971","display_name":"Network theory","level":2,"score":0.4630226492881775},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4619392156600952},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4610331356525421},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44048359990119934},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36053985357284546},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3126755356788635},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25941556692123413},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22855612635612488},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20571210980415344},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.15604296326637268},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10609227418899536},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3473258.3473283","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3473258.3473283","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 13th International Conference on Bioinformatics and Biomedical Technology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1510241967","https://openalex.org/W1917704994","https://openalex.org/W2031173759","https://openalex.org/W2042965279","https://openalex.org/W2052350776","https://openalex.org/W2067655540","https://openalex.org/W2110574342","https://openalex.org/W2117692326","https://openalex.org/W2156590681","https://openalex.org/W2160754686","https://openalex.org/W2160803964","https://openalex.org/W2591710757","https://openalex.org/W2615010141","https://openalex.org/W2767277979","https://openalex.org/W2884192683","https://openalex.org/W2988847144","https://openalex.org/W3001222395"],"related_works":["https://openalex.org/W2017899917","https://openalex.org/W2080571363","https://openalex.org/W2481322495","https://openalex.org/W2898682754","https://openalex.org/W2889841093","https://openalex.org/W2151082141","https://openalex.org/W2365236913","https://openalex.org/W3194374240","https://openalex.org/W2993861175","https://openalex.org/W2035441080"],"abstract_inverted_index":{"Lung":[0],"cancer":[1,13,41,65],"is":[2,66,96],"a":[3,48,70,90,99],"leading":[4],"cause":[5],"of":[6,19,40,57,72,101,115],"death":[7],"worldwide,":[8],"with":[9],"non-small":[10],"cell":[11],"lung":[12],"(NSCLC)":[14],"being":[15],"the":[16,20,28,32,35,55,108,122,128],"dominant":[17],"subtype":[18],"disease.":[21],"Many":[22],"biomedicine":[23],"studies":[24],"fail":[25],"to":[26,68,126,133],"explain":[27],"apparent":[29],"inconsistencies":[30,130],"between":[31],"genes":[33],"and":[34,78,131,135],"phenotypes.":[36],"The":[37,117],"spontaneous":[38],"improvement":[39],"has":[42,60],"not":[43],"yet":[44],"been":[45,61],"explained":[46],"by":[47,98],"reasonable":[49],"theory.":[50],"A":[51],"hypothesized":[52],"theory":[53],"from":[54,121],"perspective":[56],"systems":[58],"biology":[59],"proposed,":[62],"in":[63,80,93],"which":[64,94],"considered":[67],"be":[69],"result":[71],"interactions":[73],"among":[74],"multiple":[75],"conserved":[76],"modules":[77],"factors":[79],"an":[81],"endogenous":[82],"molecular-cellular":[83],"network.":[84],"In":[85],"this":[86],"work,":[87],"we":[88],"conduct":[89],"model":[91],"study":[92],"NSCLC":[95],"described":[97],"set":[100],"nonlinear":[102],"dynamical":[103],"equations.":[104],"We":[105],"show":[106],"that":[107],"network":[109],"can":[110,124],"reproduce":[111],"two":[112],"heterogeneous":[113],"subtypes":[114],"NSCLC.":[116,137],"topological":[118],"landscape":[119],"obtained":[120],"modeling":[123],"help":[125,132],"resolve":[127],"above":[129],"prevent":[134],"treat":[136]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}