{"id":"https://openalex.org/W4205593368","doi":"https://doi.org/10.1145/3473258.3473273","title":"Identification of Genes with Altered Roles in Transcription Network in Alzheimer's Disease","display_name":"Identification of Genes with Altered Roles in Transcription Network in Alzheimer's Disease","publication_year":2021,"publication_date":"2021-05-21","ids":{"openalex":"https://openalex.org/W4205593368","doi":"https://doi.org/10.1145/3473258.3473273"},"language":"en","primary_location":{"id":"doi:10.1145/3473258.3473273","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3473258.3473273","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 13th International Conference on Bioinformatics and Biomedical Technology","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073470229","display_name":"Jiaojiao Hua","orcid":"https://orcid.org/0000-0003-0913-4374"},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaojiao Hua","raw_affiliation_strings":["Chinese Academy of Sciences and University of Chinese Academy of Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences and University of Chinese Academy of Sciences, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112762772","display_name":"Shan Yu","orcid":"https://orcid.org/0000-0002-4385-6306"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Yu","raw_affiliation_strings":["Chinese Academy of Sciences and Chinese Academy of Sciences;University of Chinese Academy of Sciences, China","Chinese Academy of Sciences and Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences and Chinese Academy of Sciences;University of Chinese Academy of Sciences, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Chinese Academy of Sciences and Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28373228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"96","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.8243846297264099},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.663533091545105},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.5924948453903198},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.551576554775238},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5342649221420288},{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription (linguistics)","score":0.5207198262214661},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene ontology","score":0.5114461183547974},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.5068228840827942},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.49709823727607727},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4917507469654083},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.49021679162979126},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47966814041137695},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.4276471734046936},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09804466366767883}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.8243846297264099},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.663533091545105},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5924948453903198},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.551576554775238},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5342649221420288},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5207198262214661},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.5114461183547974},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5068228840827942},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49709823727607727},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4917507469654083},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.49021679162979126},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47966814041137695},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4276471734046936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09804466366767883},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3473258.3473273","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3473258.3473273","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 13th International Conference on Bioinformatics and Biomedical Technology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1498123445","https://openalex.org/W1527927437","https://openalex.org/W1989076425","https://openalex.org/W2035618305","https://openalex.org/W2039489843","https://openalex.org/W2055655674","https://openalex.org/W2064274168","https://openalex.org/W2110065044","https://openalex.org/W2126527896","https://openalex.org/W2146512944","https://openalex.org/W2150730731","https://openalex.org/W2151049459","https://openalex.org/W2159092541","https://openalex.org/W2159482845","https://openalex.org/W2165557965","https://openalex.org/W2169266594","https://openalex.org/W2619100129","https://openalex.org/W2808364202","https://openalex.org/W2891569200","https://openalex.org/W2904628228","https://openalex.org/W2904785741","https://openalex.org/W2904884010","https://openalex.org/W2951722595","https://openalex.org/W3043048574"],"related_works":["https://openalex.org/W2796636403","https://openalex.org/W2364565895","https://openalex.org/W2015700328","https://openalex.org/W2767847608","https://openalex.org/W2911678823","https://openalex.org/W2152648570","https://openalex.org/W2037892364","https://openalex.org/W2319154570","https://openalex.org/W3152114242","https://openalex.org/W2046672733"],"abstract_inverted_index":{"Abstract:":[0],"Differentially":[1],"expressed":[2],"genes":[3,25,58,90,93,138],"(DEGs)":[4],"are":[5,20,65],"commonly":[6],"used":[7],"to":[8,23],"study":[9],"the":[10,31,39,70,74,84,105,109,125,137,158],"pathological":[11],"mechanism":[12],"of":[13,69,76,98,111,128],"various":[14],"brain":[15],"diseases.":[16],"However,":[17],"these":[18,129],"analyses":[19],"not":[21],"sufficient":[22],"identify":[24],"that":[26,56,68,139],"alter":[27],"their":[28,63],"roles":[29],"in":[30,38,61,73,104,143,157],"transcription":[32,159],"networks":[33],"but":[34,145],"without":[35],"significant":[36,102],"changes":[37,60,103,156],"expression":[40,106],"level.":[41,107],"By":[42],"analyzing":[43],"an":[44],"RNA":[45],"microarray":[46],"dataset":[47],"(GSE36980)":[48],"from":[49],"Gene":[50],"Expression":[51],"Omnibus":[52],"(GEO),":[53],"we":[54,113],"find":[55],"many":[57],"exhibit":[59],"how":[62],"transcriptions":[64],"correlated":[66],"with":[67,83],"entire":[71],"genome":[72],"samples":[75],"Alzheimer's":[77],"disease":[78],"(AD)":[79],"patients,":[80],"when":[81],"compared":[82],"normal":[85],"controls.":[86],"We":[87],"name":[88],"such":[89],"as":[91],"role-alteration":[92],"(RAGs).":[94],"Only":[95],"a":[96],"minority":[97],"RAGs":[99],"also":[100],"show":[101],"Within":[108],"pools":[110],"RAGs,":[112],"further":[114],"identified":[115],"clustered":[116],"biological":[117],"functions":[118],"through":[119],"gene":[120],"ontology":[121],"(GO)":[122],"analyses,":[123,152],"suggesting":[124,153],"functional":[126],"significance":[127],"RAGs.":[130],"Our":[131],"work":[132],"provides":[133],"novel":[134],"insights":[135],"into":[136],"may":[140],"be":[141,147],"involved":[142],"AD":[144],"cannot":[146],"captured":[148],"by":[149],"common":[150],"DEG":[151],"more":[154],"profound":[155],"network":[160],"during":[161],"diseases":[162],"than":[163],"previously":[164],"appreciated.":[165]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}