{"id":"https://openalex.org/W3187351292","doi":"https://doi.org/10.1145/3469678.3469695","title":"Use Chou's 5-steps Rule to Study the Mechanism of Uncaria Rhynchophylla for Treating Alzheimer's Disease Based on Network Pharmacology","display_name":"Use Chou's 5-steps Rule to Study the Mechanism of Uncaria Rhynchophylla for Treating Alzheimer's Disease Based on Network Pharmacology","publication_year":2021,"publication_date":"2021-07-20","ids":{"openalex":"https://openalex.org/W3187351292","doi":"https://doi.org/10.1145/3469678.3469695","mag":"3187351292"},"language":"en","primary_location":{"id":"doi:10.1145/3469678.3469695","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3469678.3469695","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Fifth International Conference on Biological Information and Biomedical Engineering","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062822344","display_name":"Meng Fang","orcid":"https://orcid.org/0000-0002-4122-1518"},"institutions":[{"id":"https://openalex.org/I31590910","display_name":"Jianghan University","ror":"https://ror.org/041c9x778","country_code":"CN","type":"education","lineage":["https://openalex.org/I31590910"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Meng Fang","raw_affiliation_strings":["Jianghan University, China"],"affiliations":[{"raw_affiliation_string":"Jianghan University, China","institution_ids":["https://openalex.org/I31590910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110835381","display_name":"Peng Zeng","orcid":"https://orcid.org/0009-0002-2746-7156"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng Zeng","raw_affiliation_strings":["Huazhong University of Science and technology, China"],"affiliations":[{"raw_affiliation_string":"Huazhong University of Science and technology, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073825634","display_name":"Jinglou Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210146750","display_name":"Wuhan Sixth Hospital","ror":"https://ror.org/04cgmg165","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146750"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinglou Chen","raw_affiliation_strings":["Jianghan University and The Sixth Hospital of Wuhan, China"],"affiliations":[{"raw_affiliation_string":"Jianghan University and The Sixth Hospital of Wuhan, China","institution_ids":["https://openalex.org/I4210146750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101696463","display_name":"Han Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I31590910","display_name":"Jianghan University","ror":"https://ror.org/041c9x778","country_code":"CN","type":"education","lineage":["https://openalex.org/I31590910"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Zhao","raw_affiliation_strings":["Jianghan University, China"],"affiliations":[{"raw_affiliation_string":"Jianghan University, China","institution_ids":["https://openalex.org/I31590910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100672254","display_name":"Haiping Wang","orcid":"https://orcid.org/0000-0002-5114-8860"},"institutions":[{"id":"https://openalex.org/I31590910","display_name":"Jianghan University","ror":"https://ror.org/041c9x778","country_code":"CN","type":"education","lineage":["https://openalex.org/I31590910"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiping Wang","raw_affiliation_strings":["Jianghan University, China"],"affiliations":[{"raw_affiliation_string":"Jianghan University, China","institution_ids":["https://openalex.org/I31590910"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101644308","display_name":"Jing Guo","orcid":"https://orcid.org/0000-0002-8503-3746"},"institutions":[{"id":"https://openalex.org/I31590910","display_name":"Jianghan University","ror":"https://ror.org/041c9x778","country_code":"CN","type":"education","lineage":["https://openalex.org/I31590910"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Guo","raw_affiliation_strings":["Jianghan University, China"],"affiliations":[{"raw_affiliation_string":"Jianghan University, China","institution_ids":["https://openalex.org/I31590910"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5062822344"],"corresponding_institution_ids":["https://openalex.org/I31590910"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10897203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9769999980926514,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3k/akt/mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.6517646908760071},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.6289657354354858},{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.567523717880249},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.525443971157074},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.49832820892333984},{"id":"https://openalex.org/keywords/protein-kinase-b","display_name":"Protein kinase B","score":0.43660491704940796},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"Neuroprotection","score":0.43004870414733887},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"Mechanism of action","score":0.41406819224357605},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.40733179450035095},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3999759554862976},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.32556790113449097},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.2886364459991455},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.23496952652931213},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08564838767051697},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08221453428268433},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.06705209612846375}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6517646908760071},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6289657354354858},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.567523717880249},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.525443971157074},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49832820892333984},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.43660491704940796},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.43004870414733887},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.41406819224357605},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40733179450035095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3999759554862976},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32556790113449097},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2886364459991455},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23496952652931213},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08564838767051697},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08221453428268433},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.06705209612846375},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3469678.3469695","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3469678.3469695","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Fifth International Conference on Biological Information and Biomedical Engineering","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W55865925","https://openalex.org/W945743162","https://openalex.org/W1913728360","https://openalex.org/W2034070267","https://openalex.org/W2051876980","https://openalex.org/W2056095466","https://openalex.org/W2060214041","https://openalex.org/W2110841847","https://openalex.org/W2313411748","https://openalex.org/W2397764777","https://openalex.org/W2415242066","https://openalex.org/W2589392911","https://openalex.org/W2598495276","https://openalex.org/W2609394459","https://openalex.org/W2731767111","https://openalex.org/W2754986420","https://openalex.org/W2884124308","https://openalex.org/W2945624955","https://openalex.org/W2945770891","https://openalex.org/W2962161218","https://openalex.org/W2998295405","https://openalex.org/W3003864134","https://openalex.org/W3095877858","https://openalex.org/W6735888752"],"related_works":["https://openalex.org/W3183179750","https://openalex.org/W2024933597","https://openalex.org/W2070783513","https://openalex.org/W3116479654","https://openalex.org/W4205189596","https://openalex.org/W2916964185","https://openalex.org/W2422815049","https://openalex.org/W2098584395","https://openalex.org/W2982360817","https://openalex.org/W4206939639"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"tentatively":[2],"investigate":[3],"the":[4,74,92,98,145],"mechanism":[5],"of":[6,12,21,39,43,47,49,60,71,76,86,95,100,105,127,131],"uncaria":[7],"rhynchophylla":[8],"(UR)":[9],"in":[10,73,97],"treatment":[11,46,75,99],"Alzheimer's":[13],"disease":[14],"(AD).":[15],"Methods:":[16],"The":[17,56,68,83],"targets":[18,42,52,70,179],"and":[19,34,66,81,134,164,180,193],"pathways":[20,150],"UR":[22,44,61,72,96,168],"against":[23,169],"AD":[24,77,101,170],"were":[25,53,62,151],"obtained":[26,35],"from":[27],"network":[28],"pharmacology":[29],"analysis.":[30],"Results:":[31],"We":[32],"analyzed":[33],"7":[36],"active":[37,58],"ingredients":[38,59],"UR,":[40],"29":[41],"for":[45,190],"AD,":[48],"which":[50],"26.9%":[51],"protein-modifying":[54],"enzymes.":[55],"core":[57,69],"C3,":[63],"C6,":[64],"C7":[65],"C5.":[67],"are":[78],"AKT1,":[79],"CASP3":[80],"MTOR.":[82],"enrichment":[84,141,148],"analysis":[85,142],"GO":[87],"biological":[88,93,181],"process":[89],"suggests":[90],"that":[91,144],"function":[94],"mainly":[102],"involves":[103],"regulation":[104,130],"neurotransmitter":[106],"levels,":[107,125],"rhythmic":[108],"process,":[109],"cellular":[110],"response":[111,118,122],"to":[112,119,123,174],"nitrogen":[113],"compound,":[114],"calcium":[115,155],"ion":[116],"transport,":[117],"toxic":[120],"substance,":[121],"oxygen":[124],"maintenance":[126],"location,":[128],"positive":[129],"cell":[132],"death,":[133],"apoptotic":[135],"signaling":[136,149,156,159,162],"pathway,":[137,157,160],"etc.":[138],"KEGG":[139],"pathway":[140,163],"showed":[143],"most":[146],"significant":[147],"neuroactive":[152],"ligand-receptor":[153],"interaction,":[154],"cAMP":[158],"PI3K-Akt":[161],"so":[165],"on.":[166],"Conclusion:":[167],"may":[171],"be":[172],"related":[173],"its":[175],"multiple":[176,178],"components,":[177],"functions.":[182],"This":[183],"study":[184],"can":[185],"provide":[186],"a":[187],"theoretical":[188],"basis":[189],"further":[191],"experimental":[192],"clinical":[194],"research.":[195]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
