{"id":"https://openalex.org/W3197273757","doi":"https://doi.org/10.1145/3468891.3468907","title":"Predicting the Degradation of COVID-19 mRNA Vaccine with Graph Convolutional Networks","display_name":"Predicting the Degradation of COVID-19 mRNA Vaccine with Graph Convolutional Networks","publication_year":2021,"publication_date":"2021-04-23","ids":{"openalex":"https://openalex.org/W3197273757","doi":"https://doi.org/10.1145/3468891.3468907","mag":"3197273757"},"language":"en","primary_location":{"id":"doi:10.1145/3468891.3468907","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3468891.3468907","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 6th International Conference on Machine Learning Technologies","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050421008","display_name":"Yeshan Wang","orcid":"https://orcid.org/0000-0003-0329-8036"},"institutions":[{"id":"https://openalex.org/I41156924","display_name":"Victoria University of Wellington","ror":"https://ror.org/0040r6f76","country_code":"NZ","type":"education","lineage":["https://openalex.org/I41156924"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Yeshan Wang","raw_affiliation_strings":["Victoria University of Wellington, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victoria University of Wellington, New Zealand","institution_ids":["https://openalex.org/I41156924"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050421008"],"corresponding_institution_ids":["https://openalex.org/I41156924"],"apc_list":null,"apc_paid":null,"fwci":3.7555,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.92544595,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"15","issue":null,"first_page":"111","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9696000218391418,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9686999917030334,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.5957245230674744},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5738686919212341},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.5621673464775085},{"id":"https://openalex.org/keywords/degradation","display_name":"Degradation (telecommunications)","score":0.5082549452781677},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.429558128118515},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.41337910294532776},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4033263325691223},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35958197712898254},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.25384998321533203},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25164735317230225},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.178830087184906},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17466363310813904},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.1528790295124054},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1505579948425293},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12934821844100952},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.11741065979003906},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.10421252250671387}],"concepts":[{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5957245230674744},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5738686919212341},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5621673464775085},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.5082549452781677},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.429558128118515},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.41337910294532776},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4033263325691223},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35958197712898254},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25384998321533203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25164735317230225},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.178830087184906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17466363310813904},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.1528790295124054},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1505579948425293},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12934821844100952},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.11741065979003906},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10421252250671387},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3468891.3468907","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3468891.3468907","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 6th International Conference on Machine Learning Technologies","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8500000238418579}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W2064675550","https://openalex.org/W2157331557","https://openalex.org/W2519887557","https://openalex.org/W2581082771","https://openalex.org/W2787894218","https://openalex.org/W3015371627","https://openalex.org/W3035874491","https://openalex.org/W3043991892"],"related_works":["https://openalex.org/W4382894326","https://openalex.org/W3035105474","https://openalex.org/W4205698903","https://openalex.org/W4294968941","https://openalex.org/W4205413867","https://openalex.org/W3179695362","https://openalex.org/W3175450294","https://openalex.org/W3135208316","https://openalex.org/W3187621644","https://openalex.org/W4206484822"],"abstract_inverted_index":{"The":[0],"COVID-19":[1,92],"pandemic":[2],"has":[3,88],"generated":[4],"a":[5,43,53,68,101,133,160],"great":[6],"demand":[7],"for":[8,52,91],"effective":[9],"vaccines":[10,21],"to":[11,38,42,46,59,72,110],"control":[12],"SARS-CoV-2":[13],"that":[14,23],"causes":[15],"the":[16,27,30,61,84,108,112,142,155,165],"disease.":[17],"In":[18,56],"particular,":[19],"mRNA":[20,50,64,93,115],"against":[22],"virus":[24],"have":[25],"taken":[26],"lead":[28],"as":[29],"fastest":[31],"vaccine":[32],"candidates.":[33],"However,":[34],"RNA":[35,81],"molecules":[36,51,82,116],"tend":[37],"degrade":[39],"spontaneously,":[40],"leading":[41],"key":[44],"challenge":[45],"design":[47],"super":[48],"stable":[49],"refrigerator-stable":[54],"vaccine.":[55],"this":[57],"paper,":[58],"accelerate":[60],"research":[62],"of":[63,80,114],"vaccines,":[65],"we":[66,105],"develop":[67],"machine":[69],"learning":[70],"method":[71],"predict":[73,111],"likely":[74],"degradation":[75,113],"rates":[76],"at":[77,146],"each":[78],"base":[79],"in":[83,164],"Eterna":[85],"dataset,":[86],"which":[87],"been":[89],"devised":[90],"vaccines.":[94],"By":[95],"employing":[96],"graph":[97],"convolutional":[98],"networks":[99],"with":[100],"multi-head":[102],"attention":[103],"mechanism,":[104],"successfully":[106],"achieve":[107],"goal":[109],"based":[117],"on":[118,141,154],"their":[119],"structure":[120],"information.":[121],"After":[122],"applying":[123],"K-Fold":[124],"cross":[125],"validation":[126],"and":[127,157],"pseudo-label":[128],"technique,":[129],"our":[130],"model":[131],"reaches":[132],"mean":[134,137],"columnwise":[135],"root":[136],"squared":[138],"error":[139],"0.3512":[140],"Private":[143],"Test":[144],"set":[145],"Kaggle":[147,166],"platform.":[148],"Such":[149],"result":[150],"ranks":[151],"top":[152],"4%":[153],"leaderboard,":[156],"can":[158],"get":[159],"silver":[161],"medal":[162],"prize":[163],"competition.":[167]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}