{"id":"https://openalex.org/W3185224560","doi":"https://doi.org/10.1145/3460238.3460242","title":"Aberrant Thalamic Functional Connectivity for the Differential diagnosis of Bipolar Disorder and Major Depressive Disorder","display_name":"Aberrant Thalamic Functional Connectivity for the Differential diagnosis of Bipolar Disorder and Major Depressive Disorder","publication_year":2021,"publication_date":"2021-03-17","ids":{"openalex":"https://openalex.org/W3185224560","doi":"https://doi.org/10.1145/3460238.3460242","mag":"3185224560"},"language":"en","primary_location":{"id":"doi:10.1145/3460238.3460242","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3460238.3460242","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 11th International Conference on Biomedical Engineering and Technology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073614983","display_name":"Ahmed Ameen Fateh","orcid":"https://orcid.org/0000-0001-6126-274X"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ahmed Ameen Fateh","raw_affiliation_strings":["University of Electronic Science and Technology of China, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101910141","display_name":"Qian Cui","orcid":"https://orcid.org/0000-0001-7973-9649"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Cui","raw_affiliation_strings":["University of Electronic Science and Technology of China, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028696053","display_name":"Abla Smahi","orcid":"https://orcid.org/0000-0003-4371-433X"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Abla Smahi","raw_affiliation_strings":["University of Electronic Science and Technology of China, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100397375","display_name":"Yang Yang","orcid":"https://orcid.org/0000-0001-5387-8640"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yang","raw_affiliation_strings":["University of Electronic Science and Technology of China, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084720739","display_name":"Ahmed Aburas","orcid":null},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ahmed Aburas","raw_affiliation_strings":["University of Electronic Science and Technology of China, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100786255","display_name":"Huafu Chen","orcid":"https://orcid.org/0000-0002-4062-4753"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huafu Chen","raw_affiliation_strings":["University of Electronic Science and Technology of China, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China, China","institution_ids":["https://openalex.org/I150229711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150229711"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.07907331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"20","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thalamus","display_name":"Thalamus","score":0.7853612899780273},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"Major depressive disorder","score":0.6456725001335144},{"id":"https://openalex.org/keywords/functional-magnetic-resonance-imaging","display_name":"Functional magnetic resonance imaging","score":0.6207212805747986},{"id":"https://openalex.org/keywords/gyrus","display_name":"Gyrus","score":0.5634994506835938},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5631111860275269},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.49428439140319824},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"Bipolar disorder","score":0.4822307527065277},{"id":"https://openalex.org/keywords/audiology","display_name":"Audiology","score":0.45814627408981323},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4326223134994507},{"id":"https://openalex.org/keywords/superior-frontal-gyrus","display_name":"Superior frontal gyrus","score":0.4150104522705078},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.31866589188575745}],"concepts":[{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.7853612899780273},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.6456725001335144},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.6207212805747986},{"id":"https://openalex.org/C2779369059","wikidata":"https://www.wikidata.org/wiki/Q1758383","display_name":"Gyrus","level":2,"score":0.5634994506835938},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5631111860275269},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.49428439140319824},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.4822307527065277},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.45814627408981323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4326223134994507},{"id":"https://openalex.org/C2775956885","wikidata":"https://www.wikidata.org/wiki/Q3064113","display_name":"Superior frontal gyrus","level":3,"score":0.4150104522705078},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.31866589188575745}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3460238.3460242","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3460238.3460242","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 11th International Conference on Biomedical Engineering and Technology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.800000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W136264432","https://openalex.org/W154068164","https://openalex.org/W1781131011","https://openalex.org/W1976073163","https://openalex.org/W1984051795","https://openalex.org/W1990134753","https://openalex.org/W1993632568","https://openalex.org/W1994366184","https://openalex.org/W2001671863","https://openalex.org/W2003310302","https://openalex.org/W2013803050","https://openalex.org/W2018722928","https://openalex.org/W2031814251","https://openalex.org/W2044122528","https://openalex.org/W2046020459","https://openalex.org/W2048350205","https://openalex.org/W2048857243","https://openalex.org/W2070280942","https://openalex.org/W2071714444","https://openalex.org/W2080092700","https://openalex.org/W2089625484","https://openalex.org/W2093220018","https://openalex.org/W2133371501","https://openalex.org/W2134676768","https://openalex.org/W2154073373","https://openalex.org/W2160821662","https://openalex.org/W2266075323","https://openalex.org/W2314562354","https://openalex.org/W2369576125","https://openalex.org/W2594708299","https://openalex.org/W2608541548","https://openalex.org/W2711079047","https://openalex.org/W2768253102","https://openalex.org/W2784551971","https://openalex.org/W2792047249","https://openalex.org/W2794166944","https://openalex.org/W2805900668","https://openalex.org/W2896970273","https://openalex.org/W2897756004","https://openalex.org/W2899355491","https://openalex.org/W2908784848","https://openalex.org/W2917580875","https://openalex.org/W2951846486","https://openalex.org/W2972333740","https://openalex.org/W3042428310"],"related_works":["https://openalex.org/W2095009941","https://openalex.org/W3211608378","https://openalex.org/W2367866158","https://openalex.org/W2381359307","https://openalex.org/W4311687511","https://openalex.org/W1985126645","https://openalex.org/W3190599059","https://openalex.org/W3198678684","https://openalex.org/W2383755359","https://openalex.org/W2581932287"],"abstract_inverted_index":{"Bipolar":[0],"disorder":[1,9],"(BD)":[2],"is":[3,35,51,97],"regularly":[4],"misdiagnosed":[5],"as":[6],"major":[7],"depressive":[8,297],"(MDD).":[10],"BD":[11,88,107,117,196,217,258],"and":[12,24,43,56,89,108,119,137,142,148,172,180,231,239,259,271,280,292],"MDD":[13,109,114,160,219,260],"are":[14,84],"characterized":[15],"by":[16,152],"a":[17,289],"wide":[18],"range":[19],"of":[20,94,187,194,246,254,265,288],"symptoms,":[21],"cognitive":[22,57],"impairments,":[23],"altered":[25],"functional":[26,127],"connectivity":[27],"(FC)":[28],"between":[29,86,134],"different":[30],"brain":[31],"regions.":[32],"The":[33],"thalamus":[34,139,179,238],"the":[36,47,70,92,100,135,145,167,185,192,203,211,226,244,251,255,286,296],"largest":[37],"subcortical":[38],"structure":[39],"that":[40],"relays":[41],"motor":[42],"sensory":[44],"signals":[45],"to":[46,98],"cerebral":[48],"cortex,":[49],"which":[50],"crucial":[52],"for":[53],"perceptual":[54],"awareness":[55],"process.":[58],"Thalamic":[59],"dysfunction":[60],"has":[61],"been":[62],"associated":[63],"with":[64,158,208,216,236],"MDD,":[65],"whereas":[66],"fewer":[67],"studies":[68],"discussed":[69],"thalamic":[71,81,102,282],"FC":[72,82,133,165,183,201,224,242,283],"in":[73,166,184,202,225,243],"BD.":[74],"It":[75],"remains":[76],"unclear":[77],"whether":[78],"these":[79],"distinct":[80,101,263,277],"patterns":[83,264,284],"diagnosis-specific":[85],"both":[87],"MDD.":[90],"Therefore,":[91,257],"aim":[93],"this":[95],"study":[96],"determine":[99],"dysconnectivity":[103],"features":[104],"among":[105,144],"depressed":[106],"patients.":[110],"We":[111],"included":[112],"61":[113],"patients,":[115,218],"40":[116],"patients":[118,161,197,220,261],"63":[120],"healthy":[121],"controls":[122],"(HCs)":[123],"who":[124],"underwent":[125],"resting-state":[126],"magnetic":[128],"resonance":[129],"imaging":[130],"(rs-fMRI)":[131],"scanning.":[132],"left":[136,173,186,193,232,245,252,279],"right":[138,168,178,204,212,227,237,281],"was":[140],"calculated":[141],"compared":[143,207],"three":[146],"groups,":[147],"one-way":[149],"ANOVA":[150],"followed":[151],"post-hoc":[153],"t-tests":[154],"were":[155],"deployed.":[156],"Compared":[157,215],"HCs,":[159],"showed":[162,199,221,262],"an":[163,181,222,240],"increased":[164,182,223,241],"superior":[169,174,228,233],"parietal":[170,175,229,234,268],"gyrus":[171,176,190,206,230,235,249,269,274],"within":[177,191,210,250],"middle":[188,247],"temporal":[189,248,273],"thalamus.":[195,213,256],"likewise":[198],"decreased":[200],"angular":[205],"HCs":[209],"When":[214],"part":[253],"abnormal":[266,278],"thalamus-":[267,272],"FC,":[270],"FC.":[275],"These":[276],"plays":[285],"role":[287],"neurobiological":[290],"feature":[291],"potential":[293],"biomarker":[294],"differentiating":[295],"patient":[298],"groups.":[299]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}