{"id":"https://openalex.org/W3138602293","doi":"https://doi.org/10.1145/3450439.3451871","title":"Modeling longitudinal dynamics of comorbidities","display_name":"Modeling longitudinal dynamics of comorbidities","publication_year":2021,"publication_date":"2021-03-23","ids":{"openalex":"https://openalex.org/W3138602293","doi":"https://doi.org/10.1145/3450439.3451871","mag":"3138602293"},"language":"en","primary_location":{"id":"doi:10.1145/3450439.3451871","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3450439.3451871","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3450439.3451871","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Conference on Health, Inference, and Learning","raw_type":"proceedings-article"},"type":"preprint","indexed_in":["arxiv","crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dl.acm.org/doi/pdf/10.1145/3450439.3451871","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016237301","display_name":"Basil Maag","orcid":null},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Basil Maag","raw_affiliation_strings":["ETH Zurich, Zurich, Switzerland"],"affiliations":[{"raw_affiliation_string":"ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081442873","display_name":"Stefan Feuerriegel","orcid":"https://orcid.org/0000-0001-7856-8729"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stefan Feuerriegel","raw_affiliation_strings":["ETH Zurich, Zurich, Switzerland"],"affiliations":[{"raw_affiliation_string":"ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044596225","display_name":"Mathias Kraus","orcid":"https://orcid.org/0000-0002-2021-2743"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mathias Kraus","raw_affiliation_strings":["ETH Zurich, Zurich, Switzerland"],"affiliations":[{"raw_affiliation_string":"ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066579957","display_name":"Maytal Saar\u2010Tsechansky","orcid":"https://orcid.org/0000-0002-2400-3762"},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maytal Saar-Tsechansky","raw_affiliation_strings":["University of Texas at Austin"],"affiliations":[{"raw_affiliation_string":"University of Texas at Austin","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014483362","display_name":"Thomas Z\u00fcger","orcid":"https://orcid.org/0000-0001-6190-7405"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Z\u00fcger","raw_affiliation_strings":["University of Bern, Bern, Switzerland and ETH Zurich, Zurich, Switzerland"],"affiliations":[{"raw_affiliation_string":"University of Bern, Bern, Switzerland and ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I35440088"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5016237301"],"corresponding_institution_ids":["https://openalex.org/I35440088"],"apc_list":null,"apc_paid":null,"fwci":1.2064,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.78494794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"2","issue":null,"first_page":"222","last_page":"235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12246","display_name":"Chronic Disease Management Strategies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12246","display_name":"Chronic Disease Management Strategies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9793000221252441,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10793","display_name":"Diabetes Management and Education","score":0.9408000111579895,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/comorbidity","display_name":"Comorbidity","score":0.9496413469314575},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5746490955352783},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.43753692507743835},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4365345537662506},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4116789698600769},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.3332154154777527},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2276349663734436}],"concepts":[{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.9496413469314575},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5746490955352783},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.43753692507743835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4365345537662506},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4116789698600769},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3332154154777527},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2276349663734436},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1145/3450439.3451871","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3450439.3451871","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3450439.3451871","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Conference on Health, Inference, and Learning","raw_type":"proceedings-article"},{"id":"pmh:oai:arXiv.org:2103.08055","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2103.08055","pdf_url":"https://arxiv.org/pdf/2103.08055","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"doi:10.1145/3450439.3451871","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3450439.3451871","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3450439.3451871","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Conference on Health, Inference, and Learning","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G6944272000","display_name":null,"funder_award_id":"186932","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3138602293.pdf","grobid_xml":"https://content.openalex.org/works/W3138602293.grobid-xml"},"referenced_works_count":107,"referenced_works":["https://openalex.org/W1480260155","https://openalex.org/W1514049308","https://openalex.org/W1640842704","https://openalex.org/W1840902794","https://openalex.org/W1882651929","https://openalex.org/W1918304988","https://openalex.org/W1940540303","https://openalex.org/W1957910991","https://openalex.org/W1973369211","https://openalex.org/W1978789286","https://openalex.org/W1979767919","https://openalex.org/W1987401658","https://openalex.org/W1987864212","https://openalex.org/W1989118259","https://openalex.org/W1996525588","https://openalex.org/W1997009211","https://openalex.org/W2000445173","https://openalex.org/W2017457261","https://openalex.org/W2025788232","https://openalex.org/W2028871521","https://openalex.org/W2035756456","https://openalex.org/W2039800528","https://openalex.org/W2039963918","https://openalex.org/W2045656233","https://openalex.org/W2053530354","https://openalex.org/W2068772668","https://openalex.org/W2078790260","https://openalex.org/W2090866271","https://openalex.org/W2093135704","https://openalex.org/W2096613362","https://openalex.org/W2097398640","https://openalex.org/W2097771779","https://openalex.org/W2103322594","https://openalex.org/W2109556948","https://openalex.org/W2111906722","https://openalex.org/W2118248224","https://openalex.org/W2118259989","https://openalex.org/W2125838338","https://openalex.org/W2127514208","https://openalex.org/W2127960841","https://openalex.org/W2128889245","https://openalex.org/W2129383046","https://openalex.org/W2129728285","https://openalex.org/W2130501785","https://openalex.org/W2145858013","https://openalex.org/W2148327131","https://openalex.org/W2148694444","https://openalex.org/W2150845035","https://openalex.org/W2152239535","https://openalex.org/W2155943705","https://openalex.org/W2157840043","https://openalex.org/W2158468809","https://openalex.org/W2164450870","https://openalex.org/W2167587606","https://openalex.org/W2171146155","https://openalex.org/W2203714058","https://openalex.org/W2262790950","https://openalex.org/W2291271680","https://openalex.org/W2319839537","https://openalex.org/W2330856720","https://openalex.org/W2561733293","https://openalex.org/W2577537660","https://openalex.org/W2586312953","https://openalex.org/W2623902889","https://openalex.org/W2753599755","https://openalex.org/W2783570585","https://openalex.org/W2808812859","https://openalex.org/W2809928622","https://openalex.org/W2871951898","https://openalex.org/W2886780705","https://openalex.org/W2914657261","https://openalex.org/W2921051283","https://openalex.org/W2925220679","https://openalex.org/W2950666783","https://openalex.org/W2963977107","https://openalex.org/W2964194567","https://openalex.org/W2984675714","https://openalex.org/W2997206660","https://openalex.org/W2998915709","https://openalex.org/W3003879029","https://openalex.org/W3004644667","https://openalex.org/W3010543401","https://openalex.org/W3011049567","https://openalex.org/W3012523953","https://openalex.org/W3046982038","https://openalex.org/W3091627031","https://openalex.org/W3092246410","https://openalex.org/W3094485847","https://openalex.org/W3103613820","https://openalex.org/W3104822289","https://openalex.org/W3122375441","https://openalex.org/W3123421154","https://openalex.org/W3126652876","https://openalex.org/W3139495159","https://openalex.org/W3152218910","https://openalex.org/W3160263899","https://openalex.org/W3188246754","https://openalex.org/W3205961816","https://openalex.org/W4235560058","https://openalex.org/W4238255971","https://openalex.org/W4239790396","https://openalex.org/W4244018879","https://openalex.org/W4245367233","https://openalex.org/W4248681815","https://openalex.org/W4253573210","https://openalex.org/W4255101542","https://openalex.org/W4302569571"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725","https://openalex.org/W2148612803"],"abstract_inverted_index":{"In":[0,60],"medicine,":[1],"comorbidities":[2,44,57,135],"refer":[3],"to":[4,12,136,204,226,244],"the":[5,16,26,29,41,53,114,132,151,165,193,221,237,266],"presence":[6],"of":[7,18,28,43,56,94,123,168,196,255,268],"multiple,":[8],"cooccurring":[9],"diseases.":[10],"Due":[11],"their":[13],"co-occurring":[14],"nature,":[15],"course":[17,27],"one":[19],"comorbidity":[20,70,178],"is":[21,58,97,254],"often":[22],"highly":[23],"dependent":[24],"on":[25,155,170,186],"other":[30],"disease":[31,107,115,240,247],"and,":[32],"hence,":[33],"treatments":[34,169,230],"can":[35],"have":[36],"significant":[37],"spill-over":[38,161,222],"effects.":[39],"Despite":[40],"prevalence":[42],"among":[45,131],"patients,":[46],"a":[47,65,79,85,129,160,215,234,245],"comprehensive":[48],"statistical":[49],"framework":[50],"for":[51,68,105,258],"modeling":[52],"longitudinal":[54],"dynamics":[55,71],"missing.":[59],"this":[61,250],"paper,":[62],"we":[63,77,158,191,209,219],"propose":[64],"probabilistic":[66],"model":[67,83,253],"analyzing":[69],"over":[72],"time":[73],"in":[74,113,150,236,265],"patients.":[75],"Specifically,":[76],"develop":[78],"coupled":[80],"hidden":[81],"Markov":[82],"with":[84,233],"personalized,":[86],"non-homogeneous":[87],"transition":[88,152],"mechanism,":[89],"named":[90],"Comorbidity-HMM.":[91],"The":[92],"specification":[93],"our":[95,156,182,212,252],"Comorbidity-HMM":[96,184,213],"informed":[98],"by":[99,117],"clinical":[100,124,263],"research:":[101],"(1)":[102],"It":[103,127,141],"accounts":[104],"different":[106],"states":[108,120],"(i.":[109,175],"e.,":[110,176],"acute,":[111],"stable)":[112],"progression":[116,195],"introducing":[118],"latent":[119],"that":[121,163,211,224],"are":[122,231],"meaning.":[125],"(2)":[126],"models":[128,206],"coupling":[130,174],"trajectories":[133,172,189],"from":[134,241],"capture":[137],"co-evolution":[138],"dynamics.":[139],"(3)":[140],"considers":[142],"between-patient":[143],"heterogeneity":[144],"(e.":[145],"g.,":[146],"risk":[147],"factors,":[148],"treatments)":[149],"mechanism.":[153],"Based":[154],"model,":[157],"define":[159],"effect":[162,167],"measures":[164],"indirect":[166],"patient":[171],"through":[173,177],"co-evolution).":[179],"We":[180],"evaluated":[181],"proposed":[183],"based":[185],"675":[187],"health":[188],"where":[190],"investigate":[192],"joint":[194],"diabetes":[197,229],"mellitus":[198],"and":[199,262],"chronic":[200,238],"liver":[201,239],"disease.":[202],"Compared":[203],"alternative":[205],"without":[207],"coupling,":[208],"find":[210],"achieves":[214],"superior":[216],"fit.":[217],"Further,":[218],"quantify":[220],"effect,":[223],"is,":[225],"what":[227],"extent":[228],"associated":[232],"change":[235],"an":[242],"acute":[243],"stable":[246],"state.":[248],"To":[249],"end,":[251],"direct":[256],"relevance":[257],"both":[259],"treatment":[260],"planning":[261],"research":[264],"context":[267],"comorbidities.":[269]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}